This research seminar focused on the UK medicine supply system and provided an overview of issues and practices with respect to the management of supply and observed shortages. In the first part of our presentation we summarised the key issues emerging from our ongoing, exploratory research in the UK, both in ‘business-as-usual’ situations and in crisis events such as COVID-19 and Brexit. We highlighted a number of common themes across relevant UK stakeholders, including supply chain actors and other governmental and NHS England-affiliated organisations. We subsequently discussed a number of focused research projects to potentially undertake moving forward, all of which are informed by our engagement with UK stakeholders and our empirical research thus far. We concluded the seminar with a few thoughts on research methodology and design, notably the potential use of intervention-based research strategies to investigate specific aspects of the medicine shortages problem. Participants in the seminar contributed their comments, questions and reflections throughout, making it a highly interactive and fruitful event.