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Medical and Pharmaceutical Statistics Research Unit

  1. 2020
  2. Published

    Exposure–response modelling approaches for determining optimal dosing rules in children

    Wadsworth, I., Hampson, L. V., Bornkamp, B. & Jaki, T., 1/09/2020, In : Statistical Methods in Medical Research. 29, 9, p. 2583-2602 20 p.

    Research output: Contribution to journalJournal article

  3. Published

    Estimation of treatment effects following a sequential trial of multiple treatments

    Whitehead, J., Desai, Y. & Jaki, T., 20/05/2020, In : Statistics in Medicine. 39, 11, p. 1593-1609 17 p.

    Research output: Contribution to journalJournal article

  4. Published

    A quantitative framework to inform extrapolation decisions in children

    Wadsworth, I., Hampson, L. V., Jaki, T., Sills, G. J., Marson, A. G. & Appleton, R., 1/02/2020, In : Journal of the Royal Statistical Society: Series A Statistics in Society. 183, 2, p. 515-534 20 p.

    Research output: Contribution to journalJournal article

  5. 2019
  6. Published

    The R package MAMS for designing multi-arm multi-stage clinical trials

    Jaki, T. F., Pallmann, P. S. & Magirr, D., 31/01/2019, In : Journal of Statistical Software. 88, 4, 25 p.

    Research output: Contribution to journalJournal article

  7. 2018
  8. Published

    Model selection based on combined penalties for biomarker identification

    Vradi, E., Brannath, W., Jaki, T. & Vonk, R., 4/07/2018, In : Journal of Biopharmaceutical Statistics. 28, 4, p. 735-749 15 p.

    Research output: Contribution to journalJournal article

  9. Published

    Extrapolation of efficacy and other data to support the development of new medicines for children: a systematic review of methods

    Wadsworth, I., Hampson, L. V. & Jaki, T. F., 1/02/2018, In : Statistical Methods in Medical Research. 27, 2, p. 398-413 16 p.

    Research output: Contribution to journalJournal article

  10. Published

    A review of statistical updating methods for clinical prediction models

    Su, T-L., Jaki, T. F., Hickey, G., Buchan, I. & Sperrin, M., 1/01/2018, In : Statistical Methods in Medical Research. 27, 1, p. 185-197 13 p.

    Research output: Contribution to journalJournal article

  11. Published

    Identification of Predicted Individual Treatment Effects (PITE) in randomized clinical trials

    Lamont, A. E., Lyons, M., Jaki, T. F., Stuart, E. A., Feaster, D., Ishwaran, H., Tharmaratnam, K. & Van Horn, M. L., 1/01/2018, In : Statistical Methods in Medical Research. 27, 1, p. 142-157 16 p.

    Research output: Contribution to journalJournal article

  12. 2017
  13. Published

    Simultaneous confidence regions for multivariate bioequivalence

    Pallmann, P. S. & Jaki, T. F., 20/12/2017, In : Statistics in Medicine. 36, 29, p. 4585-4603 19 p.

    Research output: Contribution to journalJournal article

  14. Published

    Factorial versus multi-arm multi-stage designs for clinical trials with multiple treatments

    Jaki, T. F. & Vasileiou, D., 20/02/2017, In : Statistics in Medicine. 36, 4, p. 563-580 8 p.

    Research output: Contribution to journalJournal article

  15. Published

    Bayesian survival analysis in clinical trials: what methods are used in practice?

    Brard, C., Le Teuff, G., Le Deley, M-C. & Hampson, L. V., 1/02/2017, In : Clinical Trials. 14, 1, p. 78-87 12 p.

    Research output: Contribution to journalJournal article

  16. 2016
  17. Published

    'Threshold crossing': a useful way to establish the counterfactual in clinical trials?

    Eichler, H-G., Bloechl-Daum, B., Bauer, P., Bretz, F., Brown, J., Hampson, L. V., Honig, P., Krams, M., Leufkens, H., Lim, R., Lumpkin, M., Murphy, M., Pignatti, F., Posch, M., Schneeweiss, S., Trusheim, M. & Koenig, F., 12/2016, In : Clinical Pharmacology & Therapeutics. 100, p. 699-712 13 p.

    Research output: Contribution to journalJournal article

  18. Published

    Clinical drug development in epilepsy revisited: a proposal for a new paradigm streamlined using extrapolation

    Wadsworth, I., Jaki, T. F., Sills, G. J., Appleton, R., Cross, J. H., Marson, A. G., Martland, T., McLellan, A., Smith, P. E. M., Pellock, J. M. & Hampson, L. V., 11/2016, In : CNS Drugs. 30, 11, p. 1011-1017 7 p.

    Research output: Contribution to journalJournal article

  19. Published

    A false sense of security? can tiered approach be trusted to accurately classify immunogenicity samples?

    Jaki, T. F., Allacher, P. & Horling, F., 5/09/2016, In : Journal of Pharmaceutical and Biomedical Analysis. 128, p. 166-173 8 p.

    Research output: Contribution to journalJournal article

  20. Published

    Tilting the lasso by knowledge-based post-processing

    Tharmaratnam, K., Sperrin, M., Jaki, T. F., Reppe, S. & Frigessi, A., 2/09/2016, In : BMC Bioinformatics. 17, 9 p., 344.

    Research output: Contribution to journalJournal article

  21. Published

    Understanding clinical prediction models as ‘innovations’: a mixed methods study in UK family practice

    Brown, B., Cheraghi-Sohi, S., Jaki, T. F., Su, T-L., Buchan, I. & Sperrin, M., 9/08/2016, In : BMC Medical Informatics and Decision Making. 16, 13 p., 106.

    Research output: Contribution to journalJournal article

  22. Published

    A comparison of the barely Bayesian design with the triangular test for clinical trials in infectious diseases

    Whitehead, J. R., 08/2016, In : Clinical Trials. 13, 4, p. 451-453 3 p.

    Research output: Contribution to journalLetter

  23. Published

    Why are two mistakes not worse than one? a proposal for controlling the expected number of false claims

    Jaki, T. F. & Parry, A., 07/2016, In : Pharmaceutical Statistics. 15, 4, p. 362-367 6 p.

    Research output: Contribution to journalJournal article

  24. Published

    A review of statistical designs for improving the efficiency of phase II studies in oncology

    Wason, J. & Jaki, T., 06/2016, In : Statistical Methods in Medical Research. 25, 3, p. 1010-1021 12 p.

    Research output: Contribution to journalJournal article

  25. Published

    Impact of an equality constraint on the class-specific residual variances in regression mixtures: a Monte Carlo simulation study

    Kim, M., Lamont, A. E., Jaki, T., Feaster, D., Howe, G. & Van Horn, M. L., 06/2016, In : Behavior Research Methods. 48, 2, p. 813-826 14 p.

    Research output: Contribution to journalJournal article

  26. Published

    Modeling predictors of latent classes in regression mixture models

    Kim, M., Vermunt, J., Bakk, Z., Jaki, T. F. & Van Horn, M. L., 06/2016, In : Structural Equation Modeling. 23, 4, p. 601-614 14 p.

    Research output: Contribution to journalJournal article

  27. Published

    Experimental treatment of Ebola virus disease with TKM-130803: a single-arm phase 2 clinical trial

    RAPIDE-TKM trial team, 19/04/2016, In : PLoS Medicine. 13, 4, 19 p., e1001997.

    Research output: Contribution to journalJournal article

  28. Published

    Designing multi-arm multi-stage clinical trials using a risk-benefit criterion for treatment selection

    Jaki, T. & Hampson, L., 20/02/2016, In : Statistics in Medicine. 35, 4, p. 522-533 12 p.

    Research output: Contribution to journalJournal article

  29. Published

    Sample size reassessment and hypothesis testing in adaptive survival trials

    Magirr, D., Jaki, T. F., Koenig, F. & Posch, M., 10/02/2016, In : PLoS ONE. 11, 2, 14 p., e0146465.

    Research output: Contribution to journalJournal article

  30. Published

    Trial design for evaluating novel treatments during an outbreak of an infectious disease

    Whitehead, J. R., Olliaro, P., Lang, T. & Horby, P. W., 02/2016, In : Clinical Trials. 13, 1, p. 31-38 8 p.

    Research output: Contribution to journalJournal article

  31. Published

    Using multilevel regression mixture models to identify level-1 heterogeneity in level-2 effects

    Van Horn, M. L., Feng, Y., Kim, M., Lamont, A. E., Feaster, D. & Jaki, T., 2016, In : Structural Equation Modeling. 23, 2, p. 259-269 11 p.

    Research output: Contribution to journalJournal article

  32. 2015
  33. Published

    Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of Telmisartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on combination antiretroviral therapy

    Pushpakom, S. P., Taylor, C., Kolamunnage-Dona, R., Spowart, C., Vora, J., Garcıa-Finana, M., Kemp, G. J., Whitehead, J., Jaki, T., Khoo, S., Williamson, P. & Pirmohamed, M., 15/10/2015, In : BMJ Open. 5, 10, 13 p., e009566.

    Research output: Contribution to journalJournal article

  34. Published

    Evaluating differential effects using regression interactions and regression mixture models

    Van Horn, M. L., Jaki, T., Maysn, K., Howe, G., Feaster, D., Lamont, A. E., George, M. & Kim, M., 08/2015, In : Educational and Psychological Measurement. 75, 4, p. 677-714 38 p.

    Research output: Contribution to journalJournal article

  35. Published

    Partial stochastic dominance for the multivariate Gaussian distribution

    Turner, A. & Whitehead, J., 08/2015, In : Statistics and Probability Letters. 103, p. 80-85 6 p.

    Research output: Contribution to journalJournal article

  36. Published

    Sample size considerations in active-control non-inferiority trials with binary data based on the odds ratio

    Siqueira, A. L., Todd, S. & Whitehead, A., 08/2015, In : Statistical Methods in Medical Research. 24, 4, p. 453-461 9 p.

    Research output: Contribution to journalJournal article

  37. Published

    A practical design for a dual-agent dose-escalation trial that incorporates pharmacokinetic data

    Cotterill, A., Lorand, D., Wang, J. & Jaki, T., 15/06/2015, In : Statistics in Medicine. 34, 13, p. 2138-2164 27 p.

    Research output: Contribution to journalJournal article

  38. Published

    Adaptive clinical trials in tuberculosis: applications, challenges and solutions

    Davis, G. R., Phillips, P. P. & Jaki, T., 1/06/2015, In : International Journal of Tuberculosis and Lung Disease. 19, 6, p. 626-634 9 p.

    Research output: Contribution to journalJournal article

  39. Published

    Bayesian sample sizes for exploratory clinical trials comparing multiple experimental treatments with a control

    Whitehead, J., Cleary, F. & Turner, A., 30/05/2015, In : Statistics in Medicine. 34, 12, p. 2048-2061 14 p.

    Research output: Contribution to journalJournal article

  40. Published

    Multi-arm clinical trials with treatment selection: what can be gained and at what price?

    Jaki, T., 04/2015, In : Clinical Investigation. 5, 4, p. 393-399 7 p.

    Research output: Contribution to journalJournal article

  41. Published

    Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa

    Beresford, M. W., Bracaglia, C., Caldas, A., Cimaz, R., Dehoorne, J., Dolezalova, P., Friswell, M., Jelusic, M., Marks, S. D., Martin, N., McMahon, A-M., Peitz, J., van Royen-Kirkhof, A., Soylemezoglu, O., Brogan, P. & MYPAN Vasculitis Expert Group, 30/03/2015, In : PLoS ONE. 10, 3, 14 p., e0120981.

    Research output: Contribution to journalJournal article

  42. Published

    Statistical approaches for the determination of cut points in anti-drug antibody bioassays

    Schaarschmidt, F., Hofmann, M., Jaki, T., Gruen, B. & Hothorn, L. A., 03/2015, In : Journal of Immunological Methods. 418, p. 84-100 17 p.

    Research output: Contribution to journalJournal article

  43. Published

    Optimising the data combination rule for seamless phase II/III clinical trials

    Hampson, L. & Jennison, C., 01/2015, In : Statistics in Medicine. 34, 1, p. 39-58 20 p.

    Research output: Contribution to journalJournal article

  44. 2014
  45. Published

    Cholesterol-lowering effects of oat beta-glucan: a meta-analysis of randomized controlled trials

    Whitehead, A., Beck, E. J., Tosh, S. & Wolever, T. M. S., 1/12/2014, In : American Journal of Clinical Nutrition. 100, 6, p. 1413-1421 9 p.

    Research output: Contribution to journalJournal article

  46. Published

    Mometasone furoate cream reduces acute radiation dermatitis in patients receiving breast radiation therapy: results of a randomized trial

    Hindley, A., Zain, Z., Wood, L., Whitehead, A., Sanneh, A., Barber, D. & Hornsby, R., 15/11/2014, In : International Journal of Radiation Oncology - Biology - Physics. 90, 4, p. 748-755 8 p.

    Research output: Contribution to journalJournal article

  47. Published

    Bayesian methods for the design and interpretation of clinical trials in very rare diseases

    Hampson, L., Whitehead, J., Eleftheriou, D. & Brogan, P., 30/10/2014, In : Statistics in Medicine. 33, 24, p. 4186-4201 16 p.

    Research output: Contribution to journalJournal article

  48. Published

    Bridging the gap: a review of dose investigations in paediatric investigation plans

    Hampson, L., Herold, R., Posch, M., Saperia, J. & Whitehead, A., 10/2014, In : British Journal of Clinical Pharmacology. 78, 4, p. 898-907 10 p.

    Research output: Contribution to journalJournal article

  49. Published

    Flexible sequential designs for multi-arm clinical trials

    Magirr, D., Stallard, N. & Jaki, T., 30/08/2014, In : Statistics in Medicine. 33, 19, p. 3269-3279 11 p.

    Research output: Contribution to journalJournal article

  50. Published

    A Bayesian approach to dose finding studies for cancer therapies: incorporating later cycles of therapy

    Sinclair, K. & Whitehead, A., 10/07/2014, In : Statistics in Medicine. 33, 15, p. 2665-2680 16 p.

    Research output: Contribution to journalJournal article

  51. Published

    Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest: the randomized CIRC trial

    Wik, L., Olsen, J-A., Persse, D., Sterz, F., Lozano Jr, M., Brouwer, M. A., Westfall, M., Souders, C., Malzer, R., Grunsven, P. M. V., Travis, D., Whitehead, A., Herken, U. R. & Lerner, E. B., 06/2014, In : Resuscitation. 85, 6, p. 741-748 8 p.

    Research output: Contribution to journalJournal article

  52. Published

    A comparison of methods for classifying samples as truly specific with confirmatory immunoassays

    Jaki, T., Lawo, J-P., Wolfsegger, M. J., Allacher, P. & Horling, F., 25/01/2014, In : Journal of Pharmaceutical and Biomedical Analysis. 88, p. 27-35 9 p.

    Research output: Contribution to journalJournal article

  53. Published

    A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships

    Wolfsegger, M. J., Gutjahr, G., Engl, W. & Jaki, T., 2014, In : Biometrics. 70, 1, p. 103-109 7 p.

    Research output: Contribution to journalJournal article

  54. Published

    Designing multi-arm multi-stage clinical studies

    Jaki, T., 2014, Developments in statistical evaluation of clinical trials. van Montfort, K., Oud, J. & Ghidey, W. (eds.). Berlin: Springer, p. 51-69 19 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter (peer-reviewed)

  55. Published
  56. Published

    Statistical evaluation of toxicological assays with zero or near-to-zero proportions or counts in the concurrent negative control group: a tutorial

    Jaki, T., Kitsche, A. & Hothorn, L. A., 2014, In : JP Journal of Biostatistics. 11, 1, p. 1-32 32 p.

    Research output: Contribution to journalJournal article

  57. 2013
  58. Published

    Authors' reply to comments on "Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data settings"

    Jaki, T., Pallmann, P. & Wolfsegger, M. J., 30/12/2013, In : Statistics in Medicine. 32, 30, p. 5487-5488 2 p.

    Research output: Contribution to journalComment/debate

  59. Published

    Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs

    Jaki, T., Pallmann, P. & Wolfsegger, M. J., 30/12/2013, In : Statistics in Medicine. 32, 30, p. 5469-5483 15 p.

    Research output: Contribution to journalJournal article

  60. Published

    A tool to assess the quality of a meta-analysis

    Higgins, J. P. T., Lane, P. W., Anagnostelis, B., Anzures-Cabrera, J., Baker, N. F., Cappelleri, J. C., Haughie, S., Hollis, S., Lewis, S. C., Moneuse, P. & Whitehead, A., 12/2013, In : Research Synthesis Methods. 4, 4, p. 351-366 16 p.

    Research output: Contribution to journalJournal article

  61. Published

    Exercise and self-management for people with chronic knee, hip or lower back pain: a cluster randomised controlled trial of clinical and cost-effectiveness. Study protocol

    Walsh, N., Cramp, F., Palmer, S., Pollock, J., Hampson, L., Gooberman-Hill, R., Green, C., Jones, L., Phillips, S., Johnson, L. & Hurley, M., 12/2013, In : Physiotherapy. 99, 4, p. 352-357 6 p.

    Research output: Contribution to journalJournal article

  62. Published

    Methodological quality of meta-analyses: matched-pairs comparison over time and between industry sponsored and academic-sponsored reports

    Lane, P. W., Higgins, J. P. T., Anagnostelis, B., Anzures-Cabrera, J., Baker, N. F., Cappelleri, J. C., Haughie, S., Hollis, S., Lewis, S. C., Moneuse, P. & Whitehead, A., 12/2013, In : Research Synthesis Methods. 4, 4, p. 342-350 9 p.

    Research output: Contribution to journalJournal article

  63. Published

    Statistical evaluation of toxicological assays: Dunnett or Williams test? − take both

    Jaki, T. & Hothorn, L. A., 11/2013, In : Archives of Toxicology. 87, 11, p. 1901-1910 10 p.

    Research output: Contribution to journalJournal article

  64. Published

    Mometasone Furoate significantly reduces radiation dermatitis in patients undergoing breast radiation therapy: a double-blind randomized control trial in 120 patients

    Dunn, K., Hindley, A., Wood, L., Sanneh, A., Barber, D., Whitehead, A. & Zain, Z., 10/2013, In : International Journal of Radiation Oncology - Biology - Physics. 87, 2 Supplement, p. S115 1 p.

    Research output: Contribution to journalMeeting abstract

  65. Published

    Planning multi-arm screening studies within the context of a drug development programme

    Wason, J., Jaki, T. & Stallard, N., 10/09/2013, In : Statistics in Medicine. 32, 20, p. 3424-3435 12 p.

    Research output: Contribution to journalJournal article

  66. Published

    Differential effects of parental controls on adolescent substance use: for whom is the family most important?

    Fagan, A. A., Van Horn, M. L., Hawkins, J. D. & Jaki, T., 09/2013, In : Journal of Quantitative Criminology. 29, 3, p. 347-368 22 p.

    Research output: Contribution to journalJournal article

  67. Published

    Multiplicity: discussion points from the PSI multiplicity expert group

    Phillips, A., Fletcher, C., Atkinson, G., Channon, E., Douiri, A., Jaki, T., Maca, J., Morgan, D., Roger, J. H. & Terrill, P., 09/2013, In : Pharmaceutical Statistics. 12, 5, p. 255-259 5 p.

    Research output: Contribution to journalJournal article

  68. Published

    Analysing malaria drug trials on a per individual or a per clone basis: a comparison of methods

    Jaki, T., Parry, A., Winter, K. & Hastings, I., 30/07/2013, In : Statistics in Medicine. 32, 17, p. 3020-3038 19 p.

    Research output: Contribution to journalJournal article

  69. Published

    Designing exploratory cancer trials using change in tumour size as primary endpoint

    Jaki, T., Andre, V., Su, T-L. & Whitehead, J., 10/07/2013, In : Statistics in Medicine. 32, 15, p. 2544-2554 11 p.

    Research output: Contribution to journalJournal article

  70. Published

    Principles of dose finding studies in cancer: a comparison of trial designs

    Jaki, T., Clive, S. & Weir, C., 05/2013, In : Cancer Chemotherapy and Pharmacology. 71, 5, p. 1107-1114 8 p.

    Research output: Contribution to journalJournal article

  71. Published

    Uptake of novel statistical methods for early phase clinical studies in the UK public sector

    Jaki, T., 04/2013, In : Clinical Trials. 10, 2, p. 344-346 3 p.

    Research output: Contribution to journalJournal article

  72. Published

    Considerations on covariates and endpoints in multi-arm multi-stage clinical trials selecting all promising treatments

    Jaki, T. & Magirr, D., 30/03/2013, In : Statistics in Medicine. 32, 7, p. 1150-1163 14 p.

    Research output: Contribution to journalJournal article

  73. Published

    Cost-utility analysis conducted alongside randomized controlled trials: Are economic end points considered in sample size calculations and does it matter?

    Hollingworth, W., McKell-Redwood, D., Hampson, L. & Metcalfe, C., 02/2013, In : Clinical Trials. 10, 1, p. 43-53 11 p.

    Research output: Contribution to journalJournal article

  74. Published

    Group sequential tests for delayed responses

    Hampson, L. & Jennison, C., 01/2013, In : Journal of the Royal Statistical Society: Series B (Statistical Methodology). 75, 1, p. 3-54 52 p.

    Research output: Contribution to journalJournal article

  75. Published

    Finite mixtures for simultaneously modelling differential effects and non-normal distributions

    George, M., Yang, N., Jaki, T., Feaster, D., Lamont, A. E., Van Horn, M. L. & Wilson, D. K., 2013, In : Multivariate Behavioral Research. 48, 6, p. 816-844 29 p.

    Research output: Contribution to journalJournal article

  76. Published

    Using regression mixture models with non-normal data: examining an ordered polytomous approach

    George, M., Yang, N., Van Horn, M. L., Smith, J., Jaki, T., Feaster, D., Maysn, K. & Howe, G., 2013, In : Journal of Statistical Computation and Simulation. 83, 4, p. 757-770 14 p.

    Research output: Contribution to journalJournal article

  77. 2012
  78. Published

    Optimal design of multi-arm multi-stage trials

    Wason, J. & Jaki, T., 30/12/2012, In : Statistics in Medicine. 31, 30, p. 4269-4279 11 p.

    Research output: Contribution to journalJournal article

  79. Published

    Incorporating prognostic factors into causal estimators: a comparison of methods for RCTs with a time to event outcome

    Hampson, L. & Metcalfe, C., 20/11/2012, In : Statistics in Medicine. 31, 26, p. 3073-3088 16 p.

    Research output: Contribution to journalJournal article

  80. Published

    A bivariate Bayesian dose-finding procedure applied to a seamless phase I/II trial in rheumatoid arthritis

    Thygesen, H., Dragalin, V., Whitehead, A. & Whitehead, J., 11/2012, In : Pharmaceutical Statistics. 11, 6, p. 476-484 9 p.

    Research output: Contribution to journalJournal article

  81. Published

    C Code to design error spending tests for delayed responses

    Hampson, L. & Jennison, C., 3/09/2012

    Research output: Exhibits, objects and web-based outputsSoftware

  82. Published

    A novel phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer

    Whitehead, J., Thygesen, H., Jaki, T., Davis, S., Halford, S., Turner, H., Cook, N. & Jodrell, D., 15/08/2012, In : Statistics in Medicine. 31, 18, p. 1931-1943 13 p.

    Research output: Contribution to journalJournal article

  83. Published

    Recovering Independent Associations in Genetics: A Comparison

    Sperrin, M. & Jaki, T., 08/2012, In : Journal of Computational Biology. 19, 8, p. 978–987 10 p.

    Research output: Contribution to journalJournal article

  84. Published

    A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection

    Magirr, D., Jaki, T. & Whitehead, J., 06/2012, In : Biometrika. 99, 2, p. 494-501 8 p.

    Research output: Contribution to journalJournal article

  85. Published

    An international multicentre randomized controlled trial of G17DT in patients with pancreatic cancer

    Gilliam, A., Broome, P., Topuzov, E., Garin, A., Pulay, I., Humphreys, J., Whitehead, A., Takhar, A., Rowlands, B. & Beckingham, I., 04/2012, In : Pancreas. 41, 3, p. 374-379 6 p.

    Research output: Contribution to journalJournal article

  86. Published

    Investigating the assumption of homogeneity of treatment effects in clincal studies with application to meta-analysis

    Julious, S. & Whitehead, A., 01/2012, In : Pharmaceutical Statistics. 11, 1, p. 49-56 8 p.

    Research output: Contribution to journalJournal article

  87. Published

    Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs

    Jaki, T. & Wolfsegger, M. J., 2012, In : Statistics in Medicine. 31, 11-12, p. 1059-1073 25 p.

    Research output: Contribution to journalJournal article

  88. Published

    Not quite normal: Consequences of violating the assumption of normality with regression mixture models

    Van Horn, M. L., Smith, J., Fagan, A., Jaki, T., Maysn, K., Hawkins, D., Feaster, D. & Howe, G., 2012, In : Structural Equation Modeling. 19, 2, p. 227-249 23 p.

    Research output: Contribution to journalJournal article

  89. Published

    Spatial and temporal patterns in antimicrobial resistance of Salmonella Typhimurium amongst cattle in England and Wales

    Cox, R., Su, T-L., Clough, H., Woodward, MJ. & Sherlock, C., 2012, In : Epidemiology and Infection. p. 1-12 12 p., PMID: 22214772.

    Research output: Contribution to journalJournal article

  90. 2011
  91. Published

    Bayesian procedures for phase I/II clinical trials investigating the safety and efficacy of drug combinations

    Whitehead, J., Thygesen, H. & Whitehead, A., 20/07/2011, In : Statistics in Medicine. 30, 16, p. 1952-1970 19 p.

    Research output: Contribution to journalJournal article

  92. Published

    A formal comparison of different methods for establishing cut points to distinguish positive and negative samples in immunoassays.

    Jaki, T., Lawo, J-P., Wolfsegger, M. J., Singer, J., Allacher, P. & Horling, F., 15/07/2011, In : Journal of Pharmaceutical and Biomedical Analysis. 55, 5, p. 1148-1156 9 p.

    Research output: Contribution to journalJournal article

  93. Published

    Block response-adaptive randomization in clinical trials with binary endpoints

    Magirr, D., 07/2011, In : Pharmaceutical Statistics. 10, 4, p. 341-346 6 p.

    Research output: Contribution to journalJournal article

  94. Published

    Estimation of pharmacokinetic parameters with the R package PK.

    Jaki, T. & Wolfsegger, M. J., 05/2011, In : Pharmaceutical Statistics. 10, 2, p. 284-288 5 p.

    Research output: Contribution to journalJournal article

  95. Published

    Sequential methods for random-effects meta-analysis

    Higgins, J. P. T., Whitehead, A. & Simmonds, M., 30/04/2011, In : Statistics in Medicine. 30, 9, p. 903-921 19 p.

    Research output: Contribution to journalJournal article

  96. Published

    Design of the circulation improving resuscitation care (CIRC) trial: a new state of the art design for out-of-hospital cardiac arrest research

    Lerner, E. B., Persse, D., Souders, C., Sterz, F., Malzer, R., Lozano, M., Westfall, M., Brouwer, M. A., Grunsven, P. M. V., Whitehead, A., Olsen, J-A., Herken, U. R. & Wik, L., 03/2011, In : Resuscitation. 82, 3, p. 294-299 6 p.

    Research output: Contribution to journalJournal article

  97. Published

    Symmetric maximum kernel likelihood estimation.

    Jaki, T. & West, R. W., 02/2011, In : Journal of Statistical Computation and Simulation. 81, 2, p. 193-206 14 p.

    Research output: Contribution to journalJournal article

  98. 2010
  99. Published

    Direct effects testing : a two-stage procedure to test for effect size and variable importance for correlated binary predictors and a binary response.

    Sperrin, M. & Jaki, T., 30/10/2010, In : Statistics in Medicine. 29, 24, p. 2544-2556 13 p.

    Research output: Contribution to journalJournal article

  100. Published

    A Bayesian dose-escalation procedure for phase I clinical trials based only on the assumption of monotonicity.

    Whitehead, J., Thygesen, H. & Whitehead, A., 30/07/2010, In : Statistics in Medicine. 29, 17, p. 1808-1824 17 p.

    Research output: Contribution to journalJournal article

  101. Published

    Establishing bioequivalence in complete and incomplete data designs using AUCs.

    Jaki, T., Wolfsegger, M. J. & Lawo, J-P., 07/2010, In : Journal of Biopharmaceutical Statistics. 20, 4, p. 803-820 18 p.

    Research output: Contribution to journalJournal article

  102. Published

    Optimization, refinement and reduction of murine in vivo experiments to assess therapeutic approaches for hemophilia A.

    Baumgartner, B., Jaki, T., Wolfsegger, M. J., Eder, B., Schiviz, A., Schwarz, H. P. & Muchitsch, E. M., 07/2010, In : Laboratory Animals. 44, 3, p. 211-217 7 p.

    Research output: Contribution to journalJournal article

  103. Published

    Probabilistic relabelling strategies for the label switching problem in Bayesian mixture models.

    Sperrin, M., Jaki, T. & Wit, E., 07/2010, In : Statistics and Computing. 20, 3, p. 357-366 10 p.

    Research output: Contribution to journalJournal article

  104. Published

    Book review : Bioequivalence and statistics in clinical pharmacology.

    Jaki, T., 04/2010, In : Journal of the Royal Statistical Society: Series A Statistics in Society. 173, 2, p. 467-468 2 p.

    Research output: Contribution to journalBook/Film/Article review

  105. Published

    Geostatistical inference under preferential sampling

    Diggle, P. J., Menezes, R. & Su, T., 03/2010, In : Journal of the Royal Statistical Society: Series C (Applied Statistics). 59, 2, p. 191-232 42 p.

    Research output: Contribution to journalJournal article

  106. Published

    A combined score test for binary and ordinal endpoints from clinical trials.

    Whitehead, J., Branson, M. & Todd, S., 28/02/2010, In : Statistics in Medicine. 29, 5, p. 521-532 12 p.

    Research output: Contribution to journalJournal article

  107. 2009
  108. Published

    Assessing systemic drug exposure in repeated dose toxicity studies in the case of complete and incomplete sampling.

    Wolfsegger, M. J. & Jaki, T., 12/2009, In : Biometrical Journal. 51, 6, p. 1017-1026 10 p.

    Research output: Contribution to journalJournal article

  109. Published

    Recording lectures as a service in a service course.

    Jaki, T., 11/2009, In : Journal of Statistics Education. 17, 3

    Research output: Contribution to journalJournal article

  110. Published

    A note on statistical analysis of organ weights in non-clinical toxicological studies.

    Wolfsegger, M. J., Jaki, T., Dietrich, B., Kunzler, J. A. & Barker, K., 10/2009, In : Toxicology and Applied Pharmacology. 240, 1, p. 117-122 6 p.

    Research output: Contribution to journalJournal article

  111. Published

    Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme.

    Whitehead, J., Kelly, P., Zhou, Y., Stallard, N., Thygesen, H. & Bowman, C., 10/2009, In : Pharmaceutical Statistics. 8, 4, p. 287-300 14 p.

    Research output: Contribution to journalJournal article

  112. Published

    Non-compartmental estimation of pharmacokinetic parameters in serial sampling designs.

    Wolfsegger, M. J. & Jaki, T., 10/2009, In : Journal of Pharmacokinetics and Pharmacodynamics. 36, 5, p. 479-494

    Research output: Contribution to journalJournal article

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