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Professor Christian Holscher

Professor

  1. 2018
  2. Published

    Liraglutide Attenuates the Depressive- and Anxiety-like Behaviour in the Corticosterone Induced Depression Model Via Improving Hippocampal Neural Plasticity

    Weina, H., Yuhu, N., Hölscher, C., Birong, L., Feiyu, S. & Le, W. 1/09/2018 In : Brain Research. 1694, p. 55-62 8 p.

    Research output: Contribution to journalJournal article

  3. Published

    Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones?

    Hölscher, C., De Felice, F. G., Greig, N. & Ferreira, S. T. 1/07/2018 In : Neuropharmacology. 136, Part B, p. 159 1 p.

    Research output: Contribution to journalEditorial

  4. Published

    Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models

    Hölscher, C. 1/07/2018 In : Neuropharmacology. 136, Part B, p. 251-259 9 p.

    Research output: Contribution to journalJournal article

  5. Published

    DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease

    Cao, Y., Hölscher, C., Hu, M-M., Wang, T., Zhao, F., Bai, Y., Zhang, J., Wu, M-N. & Qi, J-S. 15/05/2018 In : European Journal of Pharmacology. 827, p. 215-226 12 p.

    Research output: Contribution to journalJournal article

  6. Published

    Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease

    Feng, P., Zhang, X., Li, D., Ji, C., Yuan, Z., Wang, R., Xue, G., Li, G. & Hölscher, C. 1/05/2018 In : Neuropharmacology. 133, p. 385-394 10 p.

    Research output: Contribution to journalJournal article

  7. Published

    Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus

    Wang, R-F., Xue, G-F., Hölscher, C., Tian, M-J., Feng, P., Zheng, J-Y. & Li, D-F. 05/2018 In : Epilepsy Research. 142, p. 45-52 8 p.

    Research output: Contribution to journalJournal article

  8. Published

    GLP-1 receptor agonists show neuroprotective effects in animal models of diabetes

    Gault, V. A. & Hölscher, C. 02/2018 In : Peptides. 100, p. 101-107 7 p.

    Research output: Contribution to journalJournal article

  9. Published

    Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease

    Tai, J., Liu, W., Li, Y., Li, L. & Hölscher, C. 1/01/2018 In : Brain Research. 1678, p. 64-74 11 p.

    Research output: Contribution to journalJournal article

  10. 2017
  11. Published

    Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells

    Panagaki, T., Michael, M. & Hölscher, C. 23/11/2017 In : Scientific Reports. 7, 16 p., 16158

    Research output: Contribution to journalJournal article

  12. Published

    A novel bioresorbable device as a controlled release system for protecting cells from oxidative stress from Alzheimer’s Disease

    Salles, G. N., Pereira, F. A. D. S., Pacheco-Soares, C., Marciano, F. R., Holscher, C., Webster, T. J. & Lobo, A. O. 11/2017 In : Molecular Neurobiology. 54, 9, p. 6827-6838 12 p.

    Research output: Contribution to journalJournal article

  13. Published

    A novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson's disease

    Yuan, Z., Li, D., Feng, P., Xue, G., Ji, C., Li, G. & Hölscher, C. 5/10/2017 In : European Journal of Pharmacology. 812, p. 82-90 9 p.

    Research output: Contribution to journalJournal article

  14. Published

    Integrating microRNA and messenger RNA expression profiles in a rat model of deep vein thrombosis

    Jin, Q-Q., Sun, J-H., Du, Q-X., Lu, X-J., Zhu, X-Y., Fan, H-L., Holscher, C. & Wang, Y-Y. 10/2017 In : International Journal of Molecular Medicine. 40, 4, p. 1019-1028 10 p.

    Research output: Contribution to journalJournal article

  15. Published

    Therapeutic Potential of Baicalein in Alzheimer's Disease and Parkinson's Disease

    Li, Y., Zhao, J. & Holscher, C. 08/2017 In : CNS Drugs. 31, 8, p. 639-652 14 p.

    Research output: Contribution to journalJournal article

  16. Published

    A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model

    Shi, L., Zhang, Z. & Hölscher, C. 1/06/2017 In : Behavioural Brain Research. 327, p. 65-74 10 p.

    Research output: Contribution to journalJournal article

  17. Published

    A novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson's disease

    Jalewa, J., Sharma, M. K., Gengler, S. & Hölscher, C. 1/05/2017 In : Neuropharmacology. 117, p. 238-248 11 p.

    Research output: Contribution to journalJournal article

  18. Published

    GLP-1/GIP/Gcg三受体激动剂改善3xTg-AD小鼠认知行为和病理特征研究

    Jiao, J-J., Hölscher, C., Li, T., Dong, X-F., Qu, X-S., Cao, Y., Wu, M-N., Wang, Z-J. & Qi, J-S. 25/04/2017 In : Acta Physiologica Sinica. 69, 2, p. 135-145 11 p.

    Research output: Contribution to journalJournal article

  19. Published

    D-Ala2-GIP-glu-PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation

    Li, Y., Liu, W., Li, L. & Holscher, C. 15/02/2017 In : European Journal of Pharmacology. 797, p. 162-172 11 p.

    Research output: Contribution to journalJournal article

  20. Published

    Lixisenatide attenuates the detrimental effects of amyloid β protein on spatial working memory and hippocampal neurons in rats

    Cai, H-Y., Wang, Z-J., Holscher, C., Yuan, L., Zhang, J., Sun, P., Li, J., Yang, W., Wu, M-N. & Qi, J-S. 1/02/2017 In : Behavioural Brain Research. 318, p. 28-35 8 p.

    Research output: Contribution to journalJournal article

  21. Published

    Levo-tetrahydropalmatine inhibits the acquisition of ketamine-induced conditioned place preference by regulating the expression of ERK and CREB phosphorylation in rats

    Du, Y., Du, L., Cao, J., Holscher, C., Feng, Y., Su, H., Wang, Y. & Yun, K-M. 15/01/2017 In : Behavioural Brain Research. 317, p. 367-373 7 p.

    Research output: Contribution to journalJournal article

  22. Published

    Therapeutic potential of flavonoids in spinal cord injury

    Zhang, P., Holscher, C. & Ma, X. 01/2017 In : Reviews in the Neurosciences. 28, 1, p. 87-101 15 p.

    Research output: Contribution to journalJournal article

  23. 2016
  24. Published

    Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases

    Li, Y., Li, L. & Holscher, C. 10/2016 In : Reviews in the Neurosciences. 27, 7, p. 689-711 23 p.

    Research output: Contribution to journalJournal article

  25. Published

    Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells

    Jalewa, J., Sharma, M. K. & Holscher, C. 10/2016 In : Journal of Neurochemistry. 139, 1, p. 55-67 13 p.

    Research output: Contribution to journalJournal article

  26. Published

    Therapeutic potential of genipin in central neurodegenerative diseases

    Li, Y., Li, L. & Holscher, C. 10/2016 In : CNS Drugs. 30, 10, p. 889-897 9 p.

    Research output: Contribution to journalJournal article

  27. Published

    Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide analogues as novel treatments for Alzheimer's and Parkinson's disease

    Hölscher, C. 09/2016 In : Cardiovascular Endocrinology . 5, 3, p. 93-98 6 p.

    Research output: Contribution to journalJournal article

  28. Published

    抗糖尿病新药(D-Ser2)Oxm 拮抗淀粉样β 蛋白细胞毒性的神经保护 效应观察

    Han, Y-F., Hölscher, C., Wang, Z-J., Zhang, J., Yuan, L., Tong, J-Q., Wang, D-D., Wu, M-N. & Qi, J-S. 25/06/2016 In : Acta Physiologica Sinica. 68, 3, p. 265-275 11 p.

    Research output: Contribution to journalJournal article

  29. Published

    A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson’s disease by reducing chronic inflammation in the brain

    Lijun, C., Li, D., Feng, P., Li, L., Xue, G., Li, G. & Holscher, C. 13/04/2016 In : NeuroReport. 27, 6, p. 384-391 8 p.

    Research output: Contribution to journalJournal article

  30. Published

    A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson′s disease by increasing expression of BNDF

    Ji, C., Xue, G-F., Lijun, C., Feng, P., Li, D., Li, L., Li, G. & Holscher, C. 1/03/2016 In : Brain Research. 1634, p. 1-11 11 p.

    Research output: Contribution to journalJournal article

  31. Published

    Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology

    Olmos-Alonso, A., Schetters, S. T. T., Sri, S., Askew, K., Mancuso, R., Vargas-Caballero, M., Holscher, C., Perry, V. H. & Gomez-Nicola, D. 1/03/2016 In : Brain. 139, 3, p. 891-907 17 p.

    Research output: Contribution to journalJournal article

  32. Published

    Alzheimer's disease–like pathology has transient effects on the brain and blood metabolome

    Pan, X., Nasaruddin, M. B., Elliott, C. T., McGuinness, B., Passmore, A. P., Kehoe, P. G., Holscher, C., McClean, P. L., Graham, S. F. & Green, B. D. 02/2016 In : Neurobiology of Aging. 38, p. 151-163 13 p.

    Research output: Contribution to journalJournal article

  33. Published

    Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model

    Li, Y., Liu, W., Li, L. & Holscher, C. 02/2016 In : Neuropharmacology. 101, p. 255-263 9 p.

    Research output: Contribution to journalJournal article

  34. Published

    Wide-ranging alterations in the brain fatty acid complement of subjects with late Alzheimer’s disease as detected by GC-MS

    Nasaruddin, M. L., Holscher, C., Kehoe, P., Graham, S. F. & Green, B. 30/01/2016 In : American Journal of Translational Research. 8, 1, p. 154-165 12 p.

    Research output: Contribution to journalJournal article

  35. Published

    A novel dual-glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist is neuroprotective in transient focal cerebral ischemia in the rat

    Han, L., Holscher, C., Xue, G., Li, G. & Li, D. 6/01/2016 In : NeuroReport. 27, 1, p. 23-32 10 p.

    Research output: Contribution to journalJournal article

  36. Published

    Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease

    Ji, C., Xue, G-F., Li, G., Li, D. & Holscher, C. 01/2016 In : Reviews in the Neurosciences. 27, 1, p. 61-70 10 p.

    Research output: Contribution to journalJournal article

  37. Published

    Neuroprotective role of (Val8)GLP-1-Glu-PAL in an in vitro model of Parkinson’s disease

    Li, L., Liu, K., Holscher, C., Li, G. & Liu, Y-Z. 2016 In : Neural Regeneration Research. 11, 2, p. 326-331 6 p.

    Research output: Contribution to journalJournal article

  38. 2015
  39. Published

    Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease

    Chen, Y., Zhang, Y., Li, L. & Holscher, C. 5/12/2015 In : European Journal of Pharmacology. 768, p. 21-27 7 p.

    Research output: Contribution to journalJournal article

  40. Published

    Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson's disease mouse model

    Zhang, Y., Chen, Y., Li, L. & Holscher, C. 15/10/2015 In : Behavioural Brain Research. 293, p. 107-113 7 p.

    Research output: Contribution to journalJournal article

  41. Published

    Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice

    McClean, P. L., Jalewa, J. & Holscher, C. 15/10/2015 In : Behavioural Brain Research. 293, p. 96-106 11 p.

    Research output: Contribution to journalJournal article

  42. Published

    Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

    Liu, W., Jalewa, J., Sharma, M., Li, G., Li, L. & Holscher, C. 10/09/2015 In : Neuroscience. 303, p. 42-50 9 p.

    Research output: Contribution to journalJournal article

  43. Published

    Neuroprotective effects of geniposide on Alzheimer's disease pathology

    Liu, W., Li, G., Holscher, C. & Li, L. 08/2015 In : Reviews in the Neurosciences. 26, 4, p. 371-383 13 p.

    Research output: Contribution to journalJournal article

  44. Published

    Pharmacological inhibition of CSF1R blocks microglial proliferation and prevents the progression of Alzheimer's-like pathology

    Olmos-Alonso, A., Schetters, S. T., Sri, S., Askew, K., Vargas-Caballero, M., Holscher, C., Perry, V. H. & Gomez-Nicola, D. 08/2015 In : Glia. 63, Suppl. 1, p. E346-E347 2 p.

    Research output: Contribution to journalMeeting abstract

  45. Published

    Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease

    Graham, S. F., Chevallier, O. P., Elliott, C. T., Holscher, C., Johnston, J., McGuinness, B., Kehoe, P. G., Passmore, A. P. & Green, B. D. 24/03/2015 In : PLoS ONE. 10, 3, 16 p., e0119452

    Research output: Contribution to journalJournal article

  46. Published

    Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with Liraglutide™

    Kelly, P., McClean, P. L., Ackermann, M., Konerding, M. A., Holscher, C. & Mitchell, C. A. 02/2015 In : Microcirculation. 22, 2, p. 133-145 13 p.

    Research output: Contribution to journalJournal article

  47. Published

    Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease

    Liu, W., Li, Y., Jalewa, J., Saunders-Wood, T., Li, L. & Hölscher, C. 2015 In : European Journal of Pharmacology. 765, p. 284-290 7 p.

    Research output: Contribution to journalJournal article

  48. Published

    Quantitative measurement of [Na+] and [K+] in postmortem human brain tissue indicates disturbances in subjects with Alzheimer's Disease and dementia with Lewy bodies

    Graham, S. F., Nasarauddin, M. B., Carey, M., McGuinness, B., Holscher, C., Kehoe, P. G., Love, S., Passmore, A. P., Elliott, C. T., Meharg, A. & Green, B. D. 2015 In : Journal of Alzheimer's Disease. 44, 3, p. 851-857 7 p.

    Research output: Contribution to journalJournal article

  49. 2014
  50. Published

    Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice

    Lennox, R., Porter, D. W., Flatt, P. R., Holscher, C., Irwin, N. & Gault, V. A. 11/2014 In : Neuropharmacology. 86, p. 22-30 9 p.

    Research output: Contribution to journalJournal article

  51. Published

    Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

    McClean, P. L. & Holscher, C. 11/2014 In : Neuropharmacology. 86, p. 241-258 18 p.

    Research output: Contribution to journalJournal article

  52. Published

    Lixisenatide rescues spatial memory and synaptic plasticity from amyloid β protein-induced impairments in rats

    Cai, H-Y., Hölscher, C., Yue, X-H., Zhang, S-X., Wang, X-H., Qiao, F., Yang, W. & Qi, J-S. 26/09/2014 In : Neuroscience. 277, p. 6-13 8 p.

    Research output: Contribution to journalJournal article

  53. Published

    Metabolic signatures of human Alzheimer's disease (AD): H-1 NMR analysis of the polar metabolome of post-mortem brain tissue

    Graham, S. F., Holscher, C. & Green, B. D. 08/2014 In : Metabolomics. 10, 4, p. 744-753 10 p.

    Research output: Contribution to journalJournal article

  54. Published

    Peptide drugs that have been developed to treat type 2 diabetes show neuroprotective effects

    Holscher, C. 06/2014 In : Regulatory Peptides. 192-193, p. 55-56 2 p.

    Research output: Contribution to journalEditorial

  55. Published

    Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

    Holscher, C. 1/04/2014 In : Journal of Endocrinology. 221, p. T31-T41 11 p.

    Research output: Contribution to journalJournal article

  56. Published

    Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

    Hölscher, C. 1/04/2014 In : Biochemical Society Transactions. 42, 2, p. 593-599 7 p.

    Research output: Contribution to journalJournal article

  57. Published

    Neural circuit interactions between the dorsal raphe nucleus and the lateral hypothalamus: an experimental and computational study

    Jalewa, J., Joshi, A., McGinnity, T. M., Prasad, G., Wong-Lin, K. & Hölscher, C. 6/02/2014 In : PLoS ONE. 9, 2, 16 p., e88003

    Research output: Contribution to journalJournal article

  58. Published

    First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease

    Hölscher, C. 02/2014 In : Alzheimer's and Dementia. 10, 1 Supplement, p. S33-37 5 p.

    Research output: Contribution to journalJournal article

  59. Published

    Neuroprotective and anti-apoptotic effects of Liraglutide on SH-SY5Y cells exposed to Methylglyoxal stress

    Sharma, M., Jalewa, J. & Hölscher, C. 02/2014 In : Journal of Neurochemistry. 128, 3, p. 459-471 13 p.

    Research output: Contribution to journalJournal article

  60. Published

    The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease

    Hölscher, C. 02/2014 In : Alzheimer's and Dementia. 10, 1 Supplement, p. S47-54 8 p.

    Research output: Contribution to journalJournal article

  61. Published

    Age-associated changes of brain copper, iron, and zinc in Alzheimer's disease and dementia with Lewy bodies

    Graham, S. F., Nasaruddin, M. B., Carey, M., Holscher, C., McGuinness, B., Kehoe, P. G., Love, S., Passmore, P., Elliott, C. T., Meharg, A. A. & Green, B. D. 2014 In : Journal of Alzheimer's Disease. 42, 4, p. 1407-1413 7 p.

    Research output: Contribution to journalJournal article

  62. 2013
  63. Published

    TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-Amyloid oligomers in mice and monkeys

    Lourenco, M. V. , Clarke, J. R. , Frozza, R. L. , Bomfim, T. R. , Forny-Germano, L. , Batista, A. F. , Sathler, L. B. , Brito-Moreira, J. , Amaral, O. B. , Silva, C. A. , Freitas-Correa, L. , Espírito-Santo, S. , Campello-Costa, P. , Houzel, J-C. , Klein, W. L. , Holscher, C. , Carvalheira, J. B. , Silva, A. M. , Velloso, L. A. , Munoz, D. P. & 2 others Ferreira, S. T. & De Felice, F. G. 3/12/2013 In : Cell Metabolism. 18, 6, p. 831-843 13 p.

    Research output: Contribution to journalJournal article

  64. Published

    New animal models of Alzheimer's disease that display insulin desensitization in the brain

    Gao, C., Liu, Y., Li, L. & Hölscher, C. 12/2013 In : Reviews in the Neurosciences. 24, 6, p. 607-615 9 p.

    Research output: Contribution to journalJournal article

  65. Published

    H-1 NMR metabolomics investigation of an Alzheimer's disease (AD) mouse model pinpoints important biochemical disturbances in brain and plasma

    Graham, S. F., Holscher, C., McClean, P., Elliot, C. T. & Green, B. D. 10/2013 In : Metabolomics. 9, 5, p. 974-983 10 p.

    Research output: Contribution to journalJournal article

  66. Published

    Intranasal insulin as a treatment for Alzheimer’s Disease: a review of basic research and clinical evidence

    Freiherr, J., Hallschmid, M., Frey, W., Brünner, Y., Chapman, C., Holscher, C., Craft, S., De Felice, F. & Benedict, C. 07/2013 In : CNS Drugs. 27, 7, p. 505-514 10 p.

    Research output: Contribution to journalJournal article

  67. Published

    Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice

    Porter, W. D., Flatt, P. R., Hölscher, C. & Gault, V. A. 05/2013 In : International Journal of Obesity. 37, 5, p. 678-684 7 p.

    Research output: Contribution to journalJournal article

  68. Published

    Neuroprotective effects of D-Ala2GIP on Alzheimer’s disease biomarkers in an APP/PS1 mouse model

    Faivre, E. & Holscher, C. 19/04/2013 In : Alzheimer's Research and Therapy. 5, p. 20-29 10 p., 20

    Research output: Contribution to journalJournal article

  69. Published

    D-Ala2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer’s disease mouse model

    Faivre, E. & Holscher, C. 8/04/2013 In : Journal of Alzheimer's Disease. 35, 2, p. 267-283 17 p.

    Research output: Contribution to journalJournal article

  70. Published

    Val⁸-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β peptide in rats

    Wang, X-H., Yang, W., Hölscher, C., Wang, Z-J., Cai, H-Y., Li, Q-S. & Qi, J-S. 04/2013 In : Journal of Neuroscience Research. 91, 4, p. 568-577 10 p.

    Research output: Contribution to journalJournal article

  71. Published

    Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model

    Parthsarathy, V. & Holscher, C. 11/03/2013 In : PLoS ONE. 8, 3, e58784

    Research output: Contribution to journalJournal article

  72. Published

    Beneficial actions of glucagon-like peptide 1 (GLP-1) on hippocampal synaptic plasticity, gene expression, oxidative stress and inflammation in mice with diet-induced obesity and insulin resistance

    Gault, V., Lennox, R., Porter, D., Holscher, C. & Flatt, P. 03/2013 In : Diabetic Medicine. 30, Supplement 1, p. 4 1 p., A9 (P99)

    Research output: Contribution to journalMeeting abstract

  73. Published

    The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease

    Long-Smith, C. M., Manning, S., McClean, P. L., Coakley, M. F., O'Halloran, D. J., Holscher, C. & O'Neill, C. 03/2013 In : NeuroMolecular Medicine. 15, 1, p. 102-114 13 p.

    Research output: Contribution to journalJournal article

  74. Published

    Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease

    Graham, S. F., Chevallier, O. P., Roberts, D., Hölscher, C., Elliott, C. T. & Green, B. D. 5/02/2013 In : Analytical Chemistry. 85, 3, p. 1803-1811 9 p.

    Research output: Contribution to journalJournal article

  75. Published

    Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats

    Han, W-N., Hölscher, C., Yuan, L., Yang, W., Wang, X-H., Wu, M-N. & Qi, J-S. 02/2013 In : Neurobiology of Aging. 34, 2, p. 576-588 13 p.

    Research output: Contribution to journalJournal article

  76. Published

    The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain

    Parthsarathy, V. & Hölscher, C. 30/01/2013 In : European Journal of Pharmacology. 700, 1-3, p. 42-50 9 p.

    Research output: Contribution to journalJournal article

  77. Published

    The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease

    Duffy, A. M. & Hölscher, C. 3/01/2013 In : Neuroscience. 228, p. 294-300 7 p.

    Research output: Contribution to journalJournal article

  78. Published

    Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer ‘s disease

    McClean, P. L. & Holscher, C. 2013 In : Neuropharmacology. 76, Part A, p. 57-67 11 p.

    Research output: Contribution to journalJournal article

  79. 2012
  80. Published

    Potential roles of glucagon-like peptide-1 (GLP-1) in neuroprotection

    Holscher, C. 10/2012 In : CNS Drugs. 26, 10, p. 871-882 12 p.

    Research output: Contribution to journalJournal article

  81. Published

    Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain

    McGovern, S. F. J., Hunter, K. & Hölscher, C. 14/09/2012 In : Brain Research. 1473, p. 204-213 10 p.

    Research output: Contribution to journalJournal article

  82. Published

    The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease

    Hamilton, A. & Holscher, C. 17/04/2012 In : Brain Research. 1449, p. 83-93 11 p.

    Research output: Contribution to journalJournal article

  83. Published

    An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

    Bomfim, T. R., Forny-Germano, L., Sathler, L. B., Brito-Moreira, J., Houzel, J-C., Decker, H., Silverman, M. A., Kazi, H., Melo, H. M., McClean, P. L., Holscher, C., Arnold, S. E., Talbot, K., Klein, W. L., Munoz, D. P., Ferreira, S. T. & De Felice, F. G. 2/04/2012 In : Journal of Clinical Investigation. 122, 4, p. 1339-1353 15 p.

    Research output: Contribution to journalJournal article

  84. Published

    GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

    Gao, C., Hölscher, C., Liu, Y. & Li, L. 02/2012 In : Reviews in the Neurosciences. 23, 1, p. 1-11 11 p.

    Research output: Contribution to journalJournal article

  85. Published

    Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

    Gengler, S., McClean, P. L., McCurtin, R., Gault, V. A. & Holscher, C. 02/2012 In : Neurobiology of Aging. 33, 2, p. 265-276 12 p.

    Research output: Contribution to journalJournal article

  86. Published

    (Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains

    Li, L., Zhang, Z-F., Hölscher, C., Gao, C., Jiang, Y-H. & Liu, Y-Z. 15/01/2012 In : European Journal of Pharmacology. 674, 2-3, p. 280-286 7 p.

    Research output: Contribution to journalJournal article

  87. Published

    Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice

    Faivre, E., Hamilton, A. & Hölscher, C. 15/01/2012 In : European Journal of Pharmacology. 674, 2-3, p. 294-306 13 p.

    Research output: Contribution to journalJournal article

  88. Published

    Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis

    Hunter, K. & Holscher, C. 2012 In : BMC Neuroscience. 13, p. 33-38 6 p.

    Research output: Contribution to journalJournal article

  89. 2011
  90. Published

    Hepcidin treatment modulates the expression of divalent metal transporter-1, ceruloplasmin, and ferroportin-1 in the rat cerebral cortex and hippocampus

    Li, L., Hölscher, C., Chen, B-B., Zhang, Z-F. & Liu, Y-Z. 12/2011 In : Biological Trace Element Research. 143, 3, p. 1581-1593 13 p.

    Research output: Contribution to journalJournal article

  91. Published

    Diabetes as a risk factor for Alzheimer’s disease: insulin signalling impairment in the brain as an alternative model of Alzheimer’s disease

    Holscher, C. 08/2011 In : Biochemical Society Transactions. 39, 4, p. 891-897 7 p.

    Research output: Contribution to journalJournal article

  92. Published

    The diabetes drug Liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease

    McClean, P. L., Parthsarathy, V., Faivre, E. & Holscher, C. 27/04/2011 In : Journal of Neuroscience. 31, 17, p. 6587-6594 8 p.

    Research output: Contribution to journalJournal article

  93. Published

    Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis

    Faivre, E., Gault, V. A., Thorens, B. & Hölscher, C. 1/04/2011 In : Journal of Neurophysiology. 105, 4, p. 1574-1580 7 p.

    Research output: Contribution to journalJournal article

  94. Published

    Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

    Hamilton, A., Patterson, S., Porter, D., Gault, V. A. & Hölscher, C. 04/2011 In : Journal of Neuroscience Research. 89, 4, p. 481-489 9 p.

    Research output: Contribution to journalJournal article

  95. Published

    Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice

    Porter, D. W., Irwin, N., Flatt, P. R., Hölscher, C. & Gault, V. A. 15/01/2011 In : European Journal of Pharmacology. 650, 2-3, p. 688-693 6 p.

    Research output: Contribution to journalJournal article

  96. 2010
  97. Published

    Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

    Porter, D. W., Kerr, B. D., Flatt, P. R., Hölscher, C. & Gault, V. A. 10/2010 In : Diabetes, Obesity and Metabolism. 12, 10, p. 891-899 9 p.

    Research output: Contribution to journalJournal article

  98. Published

    Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

    Gault, V. A., Porter, W. D., Flatt, P. R. & Holscher, C. 08/2010 In : International Journal of Obesity. 34, p. 1341-1344 4 p.

    Research output: Contribution to journalJournal article

  99. Published

    Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease

    Hölscher, C. 06/2010 In : Recent Patents on CNS Drug Discovery. 5, 2, p. 109-117 9 p.

    Research output: Contribution to journalJournal article

  100. Published

    Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease

    McClean, P. L., Gault, V. A., Harriott, P. & Hölscher, C. 25/03/2010 In : European Journal of Pharmacology. 630, 1-3, p. 158-162 5 p.

    Research output: Contribution to journalJournal article

  101. Published

    Synaptic plasticity in the hippocampus of an APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice

    Gengler, S., Hamilton, A. & Holscher, C. 22/03/2010 In : PLoS ONE. 5, 3, 10 p., e9764

    Research output: Contribution to journalJournal article

  102. Published

    The effect of mGlu8 deficiency in animal models of psychiatric diseases

    Fendt, M., Bürki, H., Imobersteg, S., van der Putten, H., McAllister, K., Leslie, J. C., Shaw, D. & Hölscher, C. 02/2010 In : Genes, Brain and Behavior. 9, 1, p. 33-44 12 p.

    Research output: Contribution to journalJournal article

  103. Published

    The role of GLP-1 in neuronal activity and neurodegeneration

    Hölscher, C. 2010 In : Vitamins and Hormones. 84, p. 331-354 24 p.

    Research output: Contribution to journalJournal article

  104. 2009
  105. Published

    Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system

    Hamilton, A. & Hölscher, C. 26/08/2009 In : NeuroReport. 20, 13, p. 1161-1166 6 p.

    Research output: Contribution to journalJournal article

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