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Professor Christian Holscher

Formerly at Lancaster University

  1. 2019
  2. Published

    Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of β-amyloid pathology

    Holubová, M., Hrubá, L., Popelová, A., Bencze, M., Pražienková, V., Gengler, S., Kratochvílová, H., Haluzík, M., Železná, B., Kuneš, J., Hölscher, C. & Maletínská, L., 01/2019, In : Neuropharmacology. 144, p. 377-387 11 p.

    Research output: Contribution to journalJournal article

  3. 2018
  4. Published

    Prolonged Drug-Releasing Fibers Attenuate Alzheimer's Disease-like Pathogenesis

    Salles, G. N., Calió, M. L., Afewerki, S., Pacheco-Soares, C., Porcionatto, M., Hölscher, C. & Lobo, A. O., 31/10/2018, In : ACS Applied Materials and Interfaces. 10, 43, p. 36693-36702 10 p.

    Research output: Contribution to journalJournal article

  5. Published

    The Novel DA-CH3 Dual Incretin Restores Endoplasmic Reticulum Stress and Autophagy Impairments to Attenuate Alzheimer-Like Pathology and Cognitive Decrements in the APPSWE/PS1ΔE9 Mouse Model

    Panagaki, T., Gengler, S. & Hölscher, C., 16/10/2018, In : Journal of Alzheimer's Disease. 66, 1, p. 195-218 24 p.

    Research output: Contribution to journalJournal article

  6. Published

    Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model

    Zhang, L., Zhang, L., Li, L. & Hölscher, C., 10/2018, In : Neuropeptides. 71, p. 70-80 11 p.

    Research output: Contribution to journalJournal article

  7. Published

    Liraglutide Attenuates the Depressive- and Anxiety-like Behaviour in the Corticosterone Induced Depression Model Via Improving Hippocampal Neural Plasticity

    Weina, H., Yuhu, N., Hölscher, C., Birong, L., Feiyu, S. & Le, W., 1/09/2018, In : Brain Research. 1694, p. 55-62 8 p.

    Research output: Contribution to journalJournal article

  8. Published

    Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones?

    Hölscher, C., De Felice, F. G., Greig, N. & Ferreira, S. T., 1/07/2018, In : Neuropharmacology. 136, Part B, p. 159 1 p.

    Research output: Contribution to journalEditorial

  9. Published

    Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models

    Hölscher, C., 1/07/2018, In : Neuropharmacology. 136, Part B, p. 251-259 9 p.

    Research output: Contribution to journalJournal article

  10. Published

    DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease

    Cao, Y., Hölscher, C., Hu, M-M., Wang, T., Zhao, F., Bai, Y., Zhang, J., Wu, M-N. & Qi, J-S., 15/05/2018, In : European Journal of Pharmacology. 827, p. 215-226 12 p.

    Research output: Contribution to journalJournal article

  11. Published

    Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease

    Feng, P., Zhang, X., Li, D., Ji, C., Yuan, Z., Wang, R., Xue, G., Li, G. & Hölscher, C., 1/05/2018, In : Neuropharmacology. 133, p. 385-394 10 p.

    Research output: Contribution to journalJournal article

  12. Published

    Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus

    Wang, R-F., Xue, G-F., Hölscher, C., Tian, M-J., Feng, P., Zheng, J-Y. & Li, D-F., 05/2018, In : Epilepsy Research. 142, p. 45-52 8 p.

    Research output: Contribution to journalJournal article

  13. Published

    GLP-1 receptor agonists show neuroprotective effects in animal models of diabetes

    Gault, V. A. & Hölscher, C., 02/2018, In : Peptides. 100, p. 101-107 7 p.

    Research output: Contribution to journalJournal article

  14. Published

    Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease

    Tai, J., Liu, W., Li, Y., Li, L. & Hölscher, C., 1/01/2018, In : Brain Research. 1678, p. 64-74 11 p.

    Research output: Contribution to journalJournal article

  15. 2017
  16. Published

    Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells

    Panagaki, T., Michael, M. & Hölscher, C., 23/11/2017, In : Scientific Reports. 7, 16 p., 16158.

    Research output: Contribution to journalJournal article

  17. Published

    A novel bioresorbable device as a controlled release system for protecting cells from oxidative stress from Alzheimer’s Disease

    Salles, G. N., Pereira, F. A. D. S., Pacheco-Soares, C., Marciano, F. R., Holscher, C., Webster, T. J. & Lobo, A. O., 11/2017, In : Molecular Neurobiology. 54, 9, p. 6827-6838 12 p.

    Research output: Contribution to journalJournal article

  18. Published

    A novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson's disease

    Yuan, Z., Li, D., Feng, P., Xue, G., Ji, C., Li, G. & Hölscher, C., 5/10/2017, In : European Journal of Pharmacology. 812, p. 82-90 9 p.

    Research output: Contribution to journalJournal article

  19. Published

    Integrating microRNA and messenger RNA expression profiles in a rat model of deep vein thrombosis

    Jin, Q-Q., Sun, J-H., Du, Q-X., Lu, X-J., Zhu, X-Y., Fan, H-L., Holscher, C. & Wang, Y-Y., 10/2017, In : International Journal of Molecular Medicine. 40, 4, p. 1019-1028 10 p.

    Research output: Contribution to journalJournal article

  20. Published

    Therapeutic Potential of Baicalein in Alzheimer's Disease and Parkinson's Disease

    Li, Y., Zhao, J. & Holscher, C., 08/2017, In : CNS Drugs. 31, 8, p. 639-652 14 p.

    Research output: Contribution to journalJournal article

  21. Published

    A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model

    Shi, L., Zhang, Z. & Hölscher, C., 1/06/2017, In : Behavioural Brain Research. 327, p. 65-74 10 p.

    Research output: Contribution to journalJournal article

  22. Published

    A novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson's disease

    Jalewa, J., Sharma, M. K., Gengler, S. & Hölscher, C., 1/05/2017, In : Neuropharmacology. 117, p. 238-248 11 p.

    Research output: Contribution to journalJournal article

  23. Published

    GLP-1/GIP/Gcg三受体激动剂改善3xTg-AD小鼠认知行为和病理特征研究

    Jiao, J-J., Hölscher, C., Li, T., Dong, X-F., Qu, X-S., Cao, Y., Wu, M-N., Wang, Z-J. & Qi, J-S., 25/04/2017, In : Acta Physiologica Sinica. 69, 2, p. 135-145 11 p.

    Research output: Contribution to journalJournal article

  24. Published

    D-Ala2-GIP-glu-PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation

    Li, Y., Liu, W., Li, L. & Holscher, C., 15/02/2017, In : European Journal of Pharmacology. 797, p. 162-172 11 p.

    Research output: Contribution to journalJournal article

  25. Published

    Lixisenatide attenuates the detrimental effects of amyloid β protein on spatial working memory and hippocampal neurons in rats

    Cai, H-Y., Wang, Z-J., Holscher, C., Yuan, L., Zhang, J., Sun, P., Li, J., Yang, W., Wu, M-N. & Qi, J-S., 1/02/2017, In : Behavioural Brain Research. 318, p. 28-35 8 p.

    Research output: Contribution to journalJournal article

  26. Published

    Levo-tetrahydropalmatine inhibits the acquisition of ketamine-induced conditioned place preference by regulating the expression of ERK and CREB phosphorylation in rats

    Du, Y., Du, L., Cao, J., Holscher, C., Feng, Y., Su, H., Wang, Y. & Yun, K-M., 15/01/2017, In : Behavioural Brain Research. 317, p. 367-373 7 p.

    Research output: Contribution to journalJournal article

  27. Published

    Therapeutic potential of flavonoids in spinal cord injury

    Zhang, P., Holscher, C. & Ma, X., 01/2017, In : Reviews in the Neurosciences. 28, 1, p. 87-101 15 p.

    Research output: Contribution to journalJournal article

  28. 2016
  29. Published

    Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases

    Li, Y., Li, L. & Holscher, C., 10/2016, In : Reviews in the Neurosciences. 27, 7, p. 689-711 23 p.

    Research output: Contribution to journalJournal article

  30. Published

    Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells

    Jalewa, J., Sharma, M. K. & Holscher, C., 10/2016, In : Journal of Neurochemistry. 139, 1, p. 55-67 13 p.

    Research output: Contribution to journalJournal article

  31. Published

    Therapeutic potential of genipin in central neurodegenerative diseases

    Li, Y., Li, L. & Holscher, C., 10/2016, In : CNS Drugs. 30, 10, p. 889-897 9 p.

    Research output: Contribution to journalJournal article

  32. Published

    Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide analogues as novel treatments for Alzheimer's and Parkinson's disease

    Hölscher, C., 09/2016, In : Cardiovascular Endocrinology . 5, 3, p. 93-98 6 p.

    Research output: Contribution to journalJournal article

  33. Published

    抗糖尿病新药(D-Ser2)Oxm 拮抗淀粉样β 蛋白细胞毒性的神经保护 效应观察

    Han, Y-F., Hölscher, C., Wang, Z-J., Zhang, J., Yuan, L., Tong, J-Q., Wang, D-D., Wu, M-N. & Qi, J-S., 25/06/2016, In : Acta Physiologica Sinica. 68, 3, p. 265-275 11 p.

    Research output: Contribution to journalJournal article

  34. Published

    A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson’s disease by reducing chronic inflammation in the brain

    Lijun, C., Li, D., Feng, P., Li, L., Xue, G., Li, G. & Holscher, C., 13/04/2016, In : NeuroReport. 27, 6, p. 384-391 8 p.

    Research output: Contribution to journalJournal article

  35. Published

    A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson′s disease by increasing expression of BNDF

    Ji, C., Xue, G-F., Lijun, C., Feng, P., Li, D., Li, L., Li, G. & Holscher, C., 1/03/2016, In : Brain Research. 1634, p. 1-11 11 p.

    Research output: Contribution to journalJournal article

  36. Published

    Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology

    Olmos-Alonso, A., Schetters, S. T. T., Sri, S., Askew, K., Mancuso, R., Vargas-Caballero, M., Holscher, C., Perry, V. H. & Gomez-Nicola, D., 1/03/2016, In : Brain. 139, 3, p. 891-907 17 p.

    Research output: Contribution to journalJournal article

  37. Published

    Alzheimer's disease–like pathology has transient effects on the brain and blood metabolome

    Pan, X., Nasaruddin, M. B., Elliott, C. T., McGuinness, B., Passmore, A. P., Kehoe, P. G., Holscher, C., McClean, P. L., Graham, S. F. & Green, B. D., 02/2016, In : Neurobiology of Aging. 38, p. 151-163 13 p.

    Research output: Contribution to journalJournal article

  38. Published

    Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model

    Li, Y., Liu, W., Li, L. & Holscher, C., 02/2016, In : Neuropharmacology. 101, p. 255-263 9 p.

    Research output: Contribution to journalJournal article

  39. Published

    Wide-ranging alterations in the brain fatty acid complement of subjects with late Alzheimer’s disease as detected by GC-MS

    Nasaruddin, M. L., Holscher, C., Kehoe, P., Graham, S. F. & Green, B., 30/01/2016, In : American Journal of Translational Research. 8, 1, p. 154-165 12 p.

    Research output: Contribution to journalJournal article

  40. Published

    A novel dual-glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist is neuroprotective in transient focal cerebral ischemia in the rat

    Han, L., Holscher, C., Xue, G., Li, G. & Li, D., 6/01/2016, In : NeuroReport. 27, 1, p. 23-32 10 p.

    Research output: Contribution to journalJournal article

  41. Published

    Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease

    Ji, C., Xue, G-F., Li, G., Li, D. & Holscher, C., 01/2016, In : Reviews in the Neurosciences. 27, 1, p. 61-70 10 p.

    Research output: Contribution to journalJournal article

  42. Published

    Neuroprotective role of (Val8)GLP-1-Glu-PAL in an in vitro model of Parkinson’s disease

    Li, L., Liu, K., Holscher, C., Li, G. & Liu, Y-Z., 2016, In : Neural Regeneration Research. 11, 2, p. 326-331 6 p.

    Research output: Contribution to journalJournal article

  43. 2015
  44. Published

    Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease

    Chen, Y., Zhang, Y., Li, L. & Holscher, C., 5/12/2015, In : European Journal of Pharmacology. 768, p. 21-27 7 p.

    Research output: Contribution to journalJournal article

  45. Published

    Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson's disease mouse model

    Zhang, Y., Chen, Y., Li, L. & Holscher, C., 15/10/2015, In : Behavioural Brain Research. 293, p. 107-113 7 p.

    Research output: Contribution to journalJournal article

  46. Published

    Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice

    McClean, P. L., Jalewa, J. & Holscher, C., 15/10/2015, In : Behavioural Brain Research. 293, p. 96-106 11 p.

    Research output: Contribution to journalJournal article

  47. Published

    Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

    Liu, W., Jalewa, J., Sharma, M., Li, G., Li, L. & Holscher, C., 10/09/2015, In : Neuroscience. 303, p. 42-50 9 p.

    Research output: Contribution to journalJournal article

  48. Published

    Neuroprotective effects of geniposide on Alzheimer's disease pathology

    Liu, W., Li, G., Holscher, C. & Li, L., 08/2015, In : Reviews in the Neurosciences. 26, 4, p. 371-383 13 p.

    Research output: Contribution to journalJournal article

  49. Published

    Pharmacological inhibition of CSF1R blocks microglial proliferation and prevents the progression of Alzheimer's-like pathology

    Olmos-Alonso, A., Schetters, S. T., Sri, S., Askew, K., Vargas-Caballero, M., Holscher, C., Perry, V. H. & Gomez-Nicola, D., 08/2015, In : Glia. 63, Suppl. 1, p. E346-E347 2 p.

    Research output: Contribution to journalMeeting abstract

  50. Published

    Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease

    Graham, S. F., Chevallier, O. P., Elliott, C. T., Holscher, C., Johnston, J., McGuinness, B., Kehoe, P. G., Passmore, A. P. & Green, B. D., 24/03/2015, In : PLoS ONE. 10, 3, 16 p., e0119452.

    Research output: Contribution to journalJournal article

  51. Published

    Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with Liraglutide™

    Kelly, P., McClean, P. L., Ackermann, M., Konerding, M. A., Holscher, C. & Mitchell, C. A., 02/2015, In : Microcirculation. 22, 2, p. 133-145 13 p.

    Research output: Contribution to journalJournal article

  52. Published

    Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease

    Liu, W., Li, Y., Jalewa, J., Saunders-Wood, T., Li, L. & Hölscher, C., 2015, In : European Journal of Pharmacology. 765, p. 284-290 7 p.

    Research output: Contribution to journalJournal article

  53. Published

    Quantitative measurement of [Na+] and [K+] in postmortem human brain tissue indicates disturbances in subjects with Alzheimer's Disease and dementia with Lewy bodies

    Graham, S. F., Nasarauddin, M. B., Carey, M., McGuinness, B., Holscher, C., Kehoe, P. G., Love, S., Passmore, A. P., Elliott, C. T., Meharg, A. & Green, B. D., 2015, In : Journal of Alzheimer's Disease. 44, 3, p. 851-857 7 p.

    Research output: Contribution to journalJournal article

  54. 2014
  55. Published

    Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice

    Lennox, R., Porter, D. W., Flatt, P. R., Holscher, C., Irwin, N. & Gault, V. A., 11/2014, In : Neuropharmacology. 86, p. 22-30 9 p.

    Research output: Contribution to journalJournal article

  56. Published

    Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

    McClean, P. L. & Holscher, C., 11/2014, In : Neuropharmacology. 86, p. 241-258 18 p.

    Research output: Contribution to journalJournal article

  57. Published

    Lixisenatide rescues spatial memory and synaptic plasticity from amyloid β protein-induced impairments in rats

    Cai, H-Y., Hölscher, C., Yue, X-H., Zhang, S-X., Wang, X-H., Qiao, F., Yang, W. & Qi, J-S., 26/09/2014, In : Neuroscience. 277, p. 6-13 8 p.

    Research output: Contribution to journalJournal article

  58. Published

    Metabolic signatures of human Alzheimer's disease (AD): H-1 NMR analysis of the polar metabolome of post-mortem brain tissue

    Graham, S. F., Holscher, C. & Green, B. D., 08/2014, In : Metabolomics. 10, 4, p. 744-753 10 p.

    Research output: Contribution to journalJournal article

  59. Published

    Peptide drugs that have been developed to treat type 2 diabetes show neuroprotective effects

    Holscher, C., 06/2014, In : Regulatory Peptides. 192-193, p. 55-56 2 p.

    Research output: Contribution to journalEditorial

  60. Published

    Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

    Holscher, C., 1/04/2014, In : Journal of Endocrinology. 221, p. T31-T41 11 p.

    Research output: Contribution to journalJournal article

  61. Published

    Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

    Hölscher, C., 1/04/2014, In : Biochemical Society Transactions. 42, 2, p. 593-599 7 p.

    Research output: Contribution to journalJournal article

  62. Published

    Neural circuit interactions between the dorsal raphe nucleus and the lateral hypothalamus: an experimental and computational study

    Jalewa, J., Joshi, A., McGinnity, T. M., Prasad, G., Wong-Lin, K. & Hölscher, C., 6/02/2014, In : PLoS ONE. 9, 2, 16 p., e88003.

    Research output: Contribution to journalJournal article

  63. Published

    First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease

    Hölscher, C., 02/2014, In : Alzheimer's and Dementia. 10, 1 Supplement, p. S33-37 5 p.

    Research output: Contribution to journalJournal article

  64. Published

    Neuroprotective and anti-apoptotic effects of Liraglutide on SH-SY5Y cells exposed to Methylglyoxal stress

    Sharma, M., Jalewa, J. & Hölscher, C., 02/2014, In : Journal of Neurochemistry. 128, 3, p. 459-471 13 p.

    Research output: Contribution to journalJournal article

  65. Published

    The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease

    Hölscher, C., 02/2014, In : Alzheimer's and Dementia. 10, 1 Supplement, p. S47-54 8 p.

    Research output: Contribution to journalJournal article

  66. Published

    Age-associated changes of brain copper, iron, and zinc in Alzheimer's disease and dementia with Lewy bodies

    Graham, S. F., Nasaruddin, M. B., Carey, M., Holscher, C., McGuinness, B., Kehoe, P. G., Love, S., Passmore, P., Elliott, C. T., Meharg, A. A. & Green, B. D., 2014, In : Journal of Alzheimer's Disease. 42, 4, p. 1407-1413 7 p.

    Research output: Contribution to journalJournal article

  67. 2013
  68. Published

    TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-Amyloid oligomers in mice and monkeys

    Lourenco, M. V., Clarke, J. R., Frozza, R. L., Bomfim, T. R., Forny-Germano, L., Batista, A. F., Sathler, L. B., Brito-Moreira, J., Amaral, O. B., Silva, C. A., Freitas-Correa, L., Espírito-Santo, S., Campello-Costa, P., Houzel, J-C., Klein, W. L., Holscher, C., Carvalheira, J. B., Silva, A. M., Velloso, L. A., Munoz, D. P. & 2 othersFerreira, S. T. & De Felice, F. G., 3/12/2013, In : Cell Metabolism. 18, 6, p. 831-843 13 p.

    Research output: Contribution to journalJournal article

  69. Published

    New animal models of Alzheimer's disease that display insulin desensitization in the brain

    Gao, C., Liu, Y., Li, L. & Hölscher, C., 12/2013, In : Reviews in the Neurosciences. 24, 6, p. 607-615 9 p.

    Research output: Contribution to journalJournal article

  70. Published

    H-1 NMR metabolomics investigation of an Alzheimer's disease (AD) mouse model pinpoints important biochemical disturbances in brain and plasma

    Graham, S. F., Holscher, C., McClean, P., Elliot, C. T. & Green, B. D., 10/2013, In : Metabolomics. 9, 5, p. 974-983 10 p.

    Research output: Contribution to journalJournal article

  71. Published

    Intranasal insulin as a treatment for Alzheimer’s Disease: a review of basic research and clinical evidence

    Freiherr, J., Hallschmid, M., Frey, W., Brünner, Y., Chapman, C., Holscher, C., Craft, S., De Felice, F. & Benedict, C., 07/2013, In : CNS Drugs. 27, 7, p. 505-514 10 p.

    Research output: Contribution to journalJournal article

  72. Published

    Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice

    Porter, W. D., Flatt, P. R., Hölscher, C. & Gault, V. A., 05/2013, In : International Journal of Obesity. 37, 5, p. 678-684 7 p.

    Research output: Contribution to journalJournal article

  73. Published

    Neuroprotective effects of D-Ala2GIP on Alzheimer’s disease biomarkers in an APP/PS1 mouse model

    Faivre, E. & Holscher, C., 19/04/2013, In : Alzheimer's Research and Therapy. 5, p. 20-29 10 p., 20.

    Research output: Contribution to journalJournal article

  74. Published

    D-Ala2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer’s disease mouse model

    Faivre, E. & Holscher, C., 8/04/2013, In : Journal of Alzheimer's Disease. 35, 2, p. 267-283 17 p.

    Research output: Contribution to journalJournal article

  75. Published

    Val⁸-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β peptide in rats

    Wang, X-H., Yang, W., Hölscher, C., Wang, Z-J., Cai, H-Y., Li, Q-S. & Qi, J-S., 04/2013, In : Journal of Neuroscience Research. 91, 4, p. 568-577 10 p.

    Research output: Contribution to journalJournal article

  76. Published

    Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model

    Parthsarathy, V. & Holscher, C., 11/03/2013, In : PLoS ONE. 8, 3, e58784.

    Research output: Contribution to journalJournal article

  77. Published

    Beneficial actions of glucagon-like peptide 1 (GLP-1) on hippocampal synaptic plasticity, gene expression, oxidative stress and inflammation in mice with diet-induced obesity and insulin resistance

    Gault, V., Lennox, R., Porter, D., Holscher, C. & Flatt, P., 03/2013, In : Diabetic Medicine. 30, Supplement 1, p. 4 1 p., A9 (P99).

    Research output: Contribution to journalMeeting abstract

  78. Published

    The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease

    Long-Smith, C. M., Manning, S., McClean, P. L., Coakley, M. F., O'Halloran, D. J., Holscher, C. & O'Neill, C., 03/2013, In : NeuroMolecular Medicine. 15, 1, p. 102-114 13 p.

    Research output: Contribution to journalJournal article

  79. Published

    Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease

    Graham, S. F., Chevallier, O. P., Roberts, D., Hölscher, C., Elliott, C. T. & Green, B. D., 5/02/2013, In : Analytical Chemistry. 85, 3, p. 1803-1811 9 p.

    Research output: Contribution to journalJournal article

  80. Published

    Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats

    Han, W-N., Hölscher, C., Yuan, L., Yang, W., Wang, X-H., Wu, M-N. & Qi, J-S., 02/2013, In : Neurobiology of Aging. 34, 2, p. 576-588 13 p.

    Research output: Contribution to journalJournal article

  81. Published

    The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain

    Parthsarathy, V. & Hölscher, C., 30/01/2013, In : European Journal of Pharmacology. 700, 1-3, p. 42-50 9 p.

    Research output: Contribution to journalJournal article

  82. Published

    The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease

    Duffy, A. M. & Hölscher, C., 3/01/2013, In : Neuroscience. 228, p. 294-300 7 p.

    Research output: Contribution to journalJournal article

  83. Published

    Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer ‘s disease

    McClean, P. L. & Holscher, C., 2013, In : Neuropharmacology. 76, Part A, p. 57-67 11 p.

    Research output: Contribution to journalJournal article

  84. 2012
  85. Published

    Potential roles of glucagon-like peptide-1 (GLP-1) in neuroprotection

    Holscher, C., 10/2012, In : CNS Drugs. 26, 10, p. 871-882 12 p.

    Research output: Contribution to journalJournal article

  86. Published

    Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain

    McGovern, S. F. J., Hunter, K. & Hölscher, C., 14/09/2012, In : Brain Research. 1473, p. 204-213 10 p.

    Research output: Contribution to journalJournal article

  87. Published

    The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease

    Hamilton, A. & Holscher, C., 17/04/2012, In : Brain Research. 1449, p. 83-93 11 p.

    Research output: Contribution to journalJournal article

  88. Published

    An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

    Bomfim, T. R., Forny-Germano, L., Sathler, L. B., Brito-Moreira, J., Houzel, J-C., Decker, H., Silverman, M. A., Kazi, H., Melo, H. M., McClean, P. L., Holscher, C., Arnold, S. E., Talbot, K., Klein, W. L., Munoz, D. P., Ferreira, S. T. & De Felice, F. G., 2/04/2012, In : Journal of Clinical Investigation. 122, 4, p. 1339-1353 15 p.

    Research output: Contribution to journalJournal article

  89. Published

    GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

    Gao, C., Hölscher, C., Liu, Y. & Li, L., 02/2012, In : Reviews in the Neurosciences. 23, 1, p. 1-11 11 p.

    Research output: Contribution to journalJournal article

  90. Published

    Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

    Gengler, S., McClean, P. L., McCurtin, R., Gault, V. A. & Holscher, C., 02/2012, In : Neurobiology of Aging. 33, 2, p. 265-276 12 p.

    Research output: Contribution to journalJournal article

  91. Published

    (Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains

    Li, L., Zhang, Z-F., Hölscher, C., Gao, C., Jiang, Y-H. & Liu, Y-Z., 15/01/2012, In : European Journal of Pharmacology. 674, 2-3, p. 280-286 7 p.

    Research output: Contribution to journalJournal article

  92. Published

    Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice

    Faivre, E., Hamilton, A. & Hölscher, C., 15/01/2012, In : European Journal of Pharmacology. 674, 2-3, p. 294-306 13 p.

    Research output: Contribution to journalJournal article

  93. Published

    Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis

    Hunter, K. & Holscher, C., 2012, In : BMC Neuroscience. 13, p. 33-38 6 p.

    Research output: Contribution to journalJournal article

  94. 2011
  95. Published

    Hepcidin treatment modulates the expression of divalent metal transporter-1, ceruloplasmin, and ferroportin-1 in the rat cerebral cortex and hippocampus

    Li, L., Hölscher, C., Chen, B-B., Zhang, Z-F. & Liu, Y-Z., 12/2011, In : Biological Trace Element Research. 143, 3, p. 1581-1593 13 p.

    Research output: Contribution to journalJournal article

  96. Published

    Diabetes as a risk factor for Alzheimer’s disease: insulin signalling impairment in the brain as an alternative model of Alzheimer’s disease

    Holscher, C., 08/2011, In : Biochemical Society Transactions. 39, 4, p. 891-897 7 p.

    Research output: Contribution to journalJournal article

  97. Published

    The diabetes drug Liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease

    McClean, P. L., Parthsarathy, V., Faivre, E. & Holscher, C., 27/04/2011, In : Journal of Neuroscience. 31, 17, p. 6587-6594 8 p.

    Research output: Contribution to journalJournal article

  98. Published

    Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis

    Faivre, E., Gault, V. A., Thorens, B. & Hölscher, C., 1/04/2011, In : Journal of Neurophysiology. 105, 4, p. 1574-1580 7 p.

    Research output: Contribution to journalJournal article

  99. Published

    Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

    Hamilton, A., Patterson, S., Porter, D., Gault, V. A. & Hölscher, C., 04/2011, In : Journal of Neuroscience Research. 89, 4, p. 481-489 9 p.

    Research output: Contribution to journalJournal article

  100. Published

    Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice

    Porter, D. W., Irwin, N., Flatt, P. R., Hölscher, C. & Gault, V. A., 15/01/2011, In : European Journal of Pharmacology. 650, 2-3, p. 688-693 6 p.

    Research output: Contribution to journalJournal article

  101. 2010
  102. Published

    Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

    Porter, D. W., Kerr, B. D., Flatt, P. R., Hölscher, C. & Gault, V. A., 10/2010, In : Diabetes, Obesity and Metabolism. 12, 10, p. 891-899 9 p.

    Research output: Contribution to journalJournal article

  103. Published

    Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

    Gault, V. A., Porter, W. D., Flatt, P. R. & Holscher, C., 08/2010, In : International Journal of Obesity. 34, p. 1341-1344 4 p.

    Research output: Contribution to journalJournal article

  104. Published

    Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease

    Hölscher, C., 06/2010, In : Recent Patents on CNS Drug Discovery. 5, 2, p. 109-117 9 p.

    Research output: Contribution to journalJournal article

  105. Published

    Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease

    McClean, P. L., Gault, V. A., Harriott, P. & Hölscher, C., 25/03/2010, In : European Journal of Pharmacology. 630, 1-3, p. 158-162 5 p.

    Research output: Contribution to journalJournal article

  106. Published

    Synaptic plasticity in the hippocampus of an APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice

    Gengler, S., Hamilton, A. & Holscher, C., 22/03/2010, In : PLoS ONE. 5, 3, 10 p., e9764.

    Research output: Contribution to journalJournal article

  107. Published

    The effect of mGlu8 deficiency in animal models of psychiatric diseases

    Fendt, M., Bürki, H., Imobersteg, S., van der Putten, H., McAllister, K., Leslie, J. C., Shaw, D. & Hölscher, C., 02/2010, In : Genes, Brain and Behavior. 9, 1, p. 33-44 12 p.

    Research output: Contribution to journalJournal article

  108. Published

    The role of GLP-1 in neuronal activity and neurodegeneration

    Hölscher, C., 2010, In : Vitamins and Hormones. 84, p. 331-354 24 p.

    Research output: Contribution to journalJournal article

  109. 2009
  110. Published

    Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system

    Hamilton, A. & Hölscher, C., 26/08/2009, In : NeuroReport. 20, 13, p. 1161-1166 6 p.

    Research output: Contribution to journalJournal article

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