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Professor Christian Holscher

Formerly at Lancaster University

  1. Published

    An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

    Bomfim, T. R., Forny-Germano, L., Sathler, L. B., Brito-Moreira, J., Houzel, J-C., Decker, H., Silverman, M. A., Kazi, H., Melo, H. M., McClean, P. L., Holscher, C., Arnold, S. E., Talbot, K., Klein, W. L., Munoz, D. P., Ferreira, S. T. & De Felice, F. G., 2/04/2012, In : Journal of Clinical Investigation. 122, 4, p. 1339-1353 15 p.

    Research output: Contribution to journalJournal article

  2. Published

    Lixisenatide rescues spatial memory and synaptic plasticity from amyloid β protein-induced impairments in rats

    Cai, H-Y., Hölscher, C., Yue, X-H., Zhang, S-X., Wang, X-H., Qiao, F., Yang, W. & Qi, J-S., 26/09/2014, In : Neuroscience. 277, p. 6-13 8 p.

    Research output: Contribution to journalJournal article

  3. Published

    Lixisenatide attenuates the detrimental effects of amyloid β protein on spatial working memory and hippocampal neurons in rats

    Cai, H-Y., Wang, Z-J., Holscher, C., Yuan, L., Zhang, J., Sun, P., Li, J., Yang, W., Wu, M-N. & Qi, J-S., 1/02/2017, In : Behavioural Brain Research. 318, p. 28-35 8 p.

    Research output: Contribution to journalJournal article

  4. Published

    DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease

    Cao, Y., Hölscher, C., Hu, M-M., Wang, T., Zhao, F., Bai, Y., Zhang, J., Wu, M-N. & Qi, J-S., 15/05/2018, In : European Journal of Pharmacology. 827, p. 215-226 12 p.

    Research output: Contribution to journalJournal article

  5. Published

    Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease

    Chen, Y., Zhang, Y., Li, L. & Holscher, C., 5/12/2015, In : European Journal of Pharmacology. 768, p. 21-27 7 p.

    Research output: Contribution to journalJournal article

  6. Published

    Levo-tetrahydropalmatine inhibits the acquisition of ketamine-induced conditioned place preference by regulating the expression of ERK and CREB phosphorylation in rats

    Du, Y., Du, L., Cao, J., Holscher, C., Feng, Y., Su, H., Wang, Y. & Yun, K-M., 15/01/2017, In : Behavioural Brain Research. 317, p. 367-373 7 p.

    Research output: Contribution to journalJournal article

  7. Published

    The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease

    Duffy, A. M. & Hölscher, C., 3/01/2013, In : Neuroscience. 228, p. 294-300 7 p.

    Research output: Contribution to journalJournal article

  8. Published

    Neuroprotective effects of D-Ala2GIP on Alzheimer’s disease biomarkers in an APP/PS1 mouse model

    Faivre, E. & Holscher, C., 19/04/2013, In : Alzheimer's Research and Therapy. 5, p. 20-29 10 p., 20.

    Research output: Contribution to journalJournal article

  9. Published

    D-Ala2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer’s disease mouse model

    Faivre, E. & Holscher, C., 8/04/2013, In : Journal of Alzheimer's Disease. 35, 2, p. 267-283 17 p.

    Research output: Contribution to journalJournal article

  10. Published

    Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice

    Faivre, E., Hamilton, A. & Hölscher, C., 15/01/2012, In : European Journal of Pharmacology. 674, 2-3, p. 294-306 13 p.

    Research output: Contribution to journalJournal article

  11. Published

    Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis

    Faivre, E., Gault, V. A., Thorens, B. & Hölscher, C., 1/04/2011, In : Journal of Neurophysiology. 105, 4, p. 1574-1580 7 p.

    Research output: Contribution to journalJournal article

  12. Published

    The effect of mGlu8 deficiency in animal models of psychiatric diseases

    Fendt, M., Bürki, H., Imobersteg, S., van der Putten, H., McAllister, K., Leslie, J. C., Shaw, D. & Hölscher, C., 02/2010, In : Genes, Brain and Behavior. 9, 1, p. 33-44 12 p.

    Research output: Contribution to journalJournal article

  13. Published

    Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease

    Feng, P., Zhang, X., Li, D., Ji, C., Yuan, Z., Wang, R., Xue, G., Li, G. & Hölscher, C., 1/05/2018, In : Neuropharmacology. 133, p. 385-394 10 p.

    Research output: Contribution to journalJournal article

  14. Published

    Intranasal insulin as a treatment for Alzheimer’s Disease: a review of basic research and clinical evidence

    Freiherr, J., Hallschmid, M., Frey, W., Brünner, Y., Chapman, C., Holscher, C., Craft, S., De Felice, F. & Benedict, C., 07/2013, In : CNS Drugs. 27, 7, p. 505-514 10 p.

    Research output: Contribution to journalJournal article

  15. Published

    New animal models of Alzheimer's disease that display insulin desensitization in the brain

    Gao, C., Liu, Y., Li, L. & Hölscher, C., 12/2013, In : Reviews in the Neurosciences. 24, 6, p. 607-615 9 p.

    Research output: Contribution to journalJournal article

  16. Published

    GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

    Gao, C., Hölscher, C., Liu, Y. & Li, L., 02/2012, In : Reviews in the Neurosciences. 23, 1, p. 1-11 11 p.

    Research output: Contribution to journalJournal article

  17. Published

    Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

    Gault, V. A., Porter, W. D., Flatt, P. R. & Holscher, C., 08/2010, In : International Journal of Obesity. 34, p. 1341-1344 4 p.

    Research output: Contribution to journalJournal article

  18. Published

    Beneficial actions of glucagon-like peptide 1 (GLP-1) on hippocampal synaptic plasticity, gene expression, oxidative stress and inflammation in mice with diet-induced obesity and insulin resistance

    Gault, V., Lennox, R., Porter, D., Holscher, C. & Flatt, P., 03/2013, In : Diabetic Medicine. 30, Supplement 1, p. 4 1 p., A9 (P99).

    Research output: Contribution to journalMeeting abstract

  19. Published

    GLP-1 receptor agonists show neuroprotective effects in animal models of diabetes

    Gault, V. A. & Hölscher, C., 02/2018, In : Peptides. 100, p. 101-107 7 p.

    Research output: Contribution to journalJournal article

  20. Published

    Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

    Gengler, S., McClean, P. L., McCurtin, R., Gault, V. A. & Holscher, C., 02/2012, In : Neurobiology of Aging. 33, 2, p. 265-276 12 p.

    Research output: Contribution to journalJournal article

  21. Published

    Synaptic plasticity in the hippocampus of an APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice

    Gengler, S., Hamilton, A. & Holscher, C., 22/03/2010, In : PLoS ONE. 5, 3, 10 p., e9764.

    Research output: Contribution to journalJournal article

  22. Published

    H-1 NMR metabolomics investigation of an Alzheimer's disease (AD) mouse model pinpoints important biochemical disturbances in brain and plasma

    Graham, S. F., Holscher, C., McClean, P., Elliot, C. T. & Green, B. D., 10/2013, In : Metabolomics. 9, 5, p. 974-983 10 p.

    Research output: Contribution to journalJournal article

  23. Published

    Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease

    Graham, S. F., Chevallier, O. P., Roberts, D., Hölscher, C., Elliott, C. T. & Green, B. D., 5/02/2013, In : Analytical Chemistry. 85, 3, p. 1803-1811 9 p.

    Research output: Contribution to journalJournal article

  24. Published

    Age-associated changes of brain copper, iron, and zinc in Alzheimer's disease and dementia with Lewy bodies

    Graham, S. F., Nasaruddin, M. B., Carey, M., Holscher, C., McGuinness, B., Kehoe, P. G., Love, S., Passmore, P., Elliott, C. T., Meharg, A. A. & Green, B. D., 2014, In : Journal of Alzheimer's Disease. 42, 4, p. 1407-1413 7 p.

    Research output: Contribution to journalJournal article

  25. Published

    Metabolic signatures of human Alzheimer's disease (AD): H-1 NMR analysis of the polar metabolome of post-mortem brain tissue

    Graham, S. F., Holscher, C. & Green, B. D., 08/2014, In : Metabolomics. 10, 4, p. 744-753 10 p.

    Research output: Contribution to journalJournal article

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