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Research

Professor David Allsop

Formerly at Lancaster University

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  1. 2009
  2. Published

    Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis

    Kasai, T., Tokuda, T., Ishigami, N., Sasayama, H., Foulds, P., Mitchell, D. J., Mann, D. M. A., Allsop, D. & Nakagawa, M., 2009, In: Acta Neuropathologica. 117, 1, p. 55-62 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration

    Foulds, P., Davidson, Y., Mishra, M., Hobson, D. J., Humphreys, K. M., Taylor, M., Johnson, N., Weintraub, S., Akiyama, H., Arai, T., Hasegawa, M., Bigio, E. H., Benson, F. E., Allsop, D. & Mann, D. M. A., 2009, In: Acta Neuropathologica. 118, 5, p. 647-658 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. 2008
  5. Published

    Designing peptide inhibitors for oligomerization and toxicity of Alzheimer's β-amyloid peptide

    Austen, B. M., Paleologou, K. E., Ali, S. A. E., Qureshi, M. M., Allsop, D. & El-Agnaf, O. M. A., 2008, In: Biochemistry. 47, 7, p. 1984-1992 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Metal-dependent generation of reactive oxygen species from amyloid proteins implicated in neurodegenerative disease

    Allsop, D., Mayes, J., Moore, S., Masad, A. & Tabner, B. J., 2008, In: Biochemical Society Transactions. 36, 6, p. 1293-1298 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration

    Foulds, P., McAuley, E., Gibbons, L., Davidson, Y., Pickering-Brown, S. M., Neary, D., Snowden, J. S., Allsop, D. & Mann, D. M. A., 2008, In: Acta Neuropathologica. 116, 2, p. 141-146 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. 2007
  9. Published

    An investigation into the lipid-binding properties of α-, β- and γ-synucleins in human brain and cerebrospinal fluid

    Salem, S. A., Allsop, D., Mann, D. M. A., Tokuda, T. & El-Agnaf, O. M. A., 19/09/2007, In: Experimental Brain Research. 1170, p. 103-111 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Copper-mediated formation of hydrogen peroxide from the amylin peptide: a novel mechanism for degeneration of islet cells in type-2 diabetes mellitus?

    Masad, A., Hayes, L., Tabner, B., Turnbull, S., Cooper, L., Fullwood, N. J., German, M., Kametani, F., El-Agnaf, O. M. A. & Allsop, D., 2007, In: FEBS Letters. 581, 18, p. 3489-3493 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. 2006
  12. Published

    Plasma amyloid-β concentrations in Alzheimer's disease : an alternative hypothesis.

    Fullwood, N. J., Hayashi, Y. & Allsop, D., 12/2006, In: Lancet Neurology. 5, 12, p. 1000-1001 2 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease.

    Tokuda, T., Salem, S. A., Allsop, D., Mizuno, T., Nakagawa, M., Qureshi, M. M., Locascio, J. J., Schlossmacher, M. G. & El-Agnaf, O., 13/10/2006, In: Biochemical and Biophysical Research Communications. 349, 1, p. 162-166 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    Donepezil for severe Alzheimer's disease.

    Allsop, D., Martin, F., Moore, S. & Fullwood, N. J., 29/07/2006, In: Lancet. 368, 9533, p. 361-362 2 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on β-amyloid and α-synuclein.

    Tabner, B. J., Turnbull, S., King, J., Benson, F. E., El-Agnaf, O. M. A. & Allsop, D., 07/2006, In: Free Radical Research. 40, 7, p. 731-739 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    Detection of oligomeric forms of α-synuclein protein in human plasma as a potential biomarker for Parkinson’s disease

    El-Agnaf, O. M. A., Salem, S. A., Paleologou, K. E., Curran, M. D., Gibson, M. J., Court, J. A., Schlossmacher, M. G. & Allsop, D., 2006, In: FASEB Journal. 20, 3, p. 419-425 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. 2005
  18. Published

    Protein aggregation, metals and oxidative stress in neurodegenerative diseases.

    Tabner, B. J., El-Agnaf, O. M. A., German, M. J., Fullwood, N. J. & Allsop, D., 11/2005, In: Biochemical Society Transactions. 33, 5, p. 1082-1086 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer's disease and familial British dementia.

    Tabner, B. J., El-Agnaf, O. M. A., Turnbull, S., German, M. J., Paleologou, K. E., Hayashi, Y., Cooper, L. J., Fullwood, N. & Allsop, D., 28/10/2005, In: Journal of Biological Chemistry. 280, 43, p. 35789-35792 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?

    Tabner, B., Turnbull, S., Fullwood, N. J., German, M. & Allsop, D., 08/2005, In: Biochemical Society Transactions. 33, 4, p. 548-550 3 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. 2004
  22. Published

    A strategy for designing inhibitors of α-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.

    El-Agnaf, O. M. A., Paleologou, K. E., Greer, B., Abogrein, A. M., King, J., Salem, S. A., Fullwood, N. J., Benson, F. E., Hewitt, R., Ford, K. J., Martin, F., Harriott, P., Cookson, M. R. & Allsop, D., 08/2004, In: FASEB Journal. 18, 11, p. 1315-1317 3 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    Both the D-(+) and L-(-) enantiomers of nicotine inhibit Aβ aggregation and cytotoxicity.

    Moore, S. A., Huckerby, T. N., Gibson, G. L., Fullwood, N. J., Turnbull, I., Tabner, B. J., El-Agnaf, O. M. A. & Allsop, D., 01/2004, In: Biochemistry. 43, 3, p. 819-826 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    Induction of cellular oxidative stress by the β-amyloid peptide involved in Alzheimer's disease.

    Gibson, G. L., Allsop, D. & Austen, B. M., 2004, In: Protein and Peptide Letters. 11, 3, p. 257-270 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    α-Synuclein and the pathogenesis of Parkinson’s disease.

    Martin, F., Allsop, D., Williamson, S. J. M., Paleologou, K. E. & El-Agnaf, O. M. A., 2004, In: Protein and Peptide Letters. 11, 3, p. 229-237 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  26. 2003
  27. Published

    Fe(II)-induced DNA damage in α-synuclein-transfected human dopaminergic BE(2)-M17 neuroblastoma cells: detection by the Comet assay.

    Martin, F., Williamson, S. J. M., Paleologou, K. E., Hewitt, R., El-Agnaf, O. M. A. & Allsop, D., 11/2003, In: Journal of Neurochemistry. 87, 3, p. 620-630 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  28. Published

    α-Synuclein implicated in Parkinson’s disease is present in extracellular biological fluids, including human plasma.

    El-Agnaf, O. M. A., Salem, S. A., Paleologou, K. E., Cooper, L. J., Fullwood, N. J., Gibson, M. J., Curran, M. D., Court, J. A., Mann, D. M. A., Ikeda, S-I., Cookson, M. R., Hardy, J. & Allsop, D., 10/2003, In: FASEB Journal. 17, 13, p. 1945-1947 3 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  29. Published

    Quinacrine acts as an antioxidant and reduces the toxicity of the prion peptide PrP106-126.

    Turnbull, S., Tabner, B. J., Brown, D. R. & Allsop, D., 15/09/2003, In: NeuroReport. 14, 13, p. 1743-1745 3 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  30. Published

    Soluble oligomers for the diagnosis of neurodegenerative diseases.

    El-Agnaf, O. M. A., Walsh, D. M. & Allsop, D., 08/2003, In: Lancet Neurology. 2, 8, p. 461-462 2 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  31. Published

    Generation of hydrogen peroxide from mutant forms of the prion protein fragment PrP121-231.

    Turnbull, S., Tabner, B. J., Brown, D. R. & Allsop, D., 1/07/2003, In: Biochemistry. 42, 25, p. 7675-7681 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  32. Published

    Copper-dependent generation of hydrogen peroxide from the toxic prion protein fragment PrP106-126.

    Turnbull, S., Tabner, B. J., Brown, D. R. & Allsop, D., 23/01/2003, In: Neuroscience Letters. 336, 3, p. 159-162 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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