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Dr Edward Parkin

Senior Lecturer

  1. 2018
  2. Published

    Osteonectin as a screening marker for pancreatic cancer: A prospective study

    Papapanagiotou, A., Sgourakis, G., Karkoulias, K., Raptis, D., Parkin, E. T., Brotzakis, P., Panchal, S. & Papavassiliou, A., 1/07/2018, In : Journal of International Medical Research. 46, 7, p. 2769-2779 11 p.

    Research output: Contribution to journalJournal article

  3. 2016
  4. Published

    Notch Signalling as a Therapeutic Target in Cancer

    Martinas, I. & Parkin, E. T., 10/2016, In : International Journal of Cancer Therapy and Oncology. 4, 4

    Research output: Contribution to journalLiterature review

  5. Published

    Pyruvate dehydrogenase kinase inhibition: reversing the Warburg effect in cancer therapy

    Bell, H. & Parkin, E. T., 23/06/2016, In : International Journal of Cancer Therapy and Oncology. 4, 2, p. 4215-4227 12 p.

    Research output: Contribution to journalLiterature review

  6. Published

    Stroma-induced Jagged1 expression drives PC3 prostate cancer cell migration: disparate effects of RIP-generated proteolytic fragments on cell behaviour and Notch signaling

    Delury, C. P., Hart, C., Brown, M., Clarke, N. & Parkin, E. T., 25/03/2016, In : Biochemical and Biophysical Research Communications. 472, 1, p. 255-261 7 p.

    Research output: Contribution to journalJournal article

  7. 2015
  8. Published

    The E1 copper binding domain of full-length amyloid precursor protein promotes epithelial to mesenchymal transition in DU145 cells in isoform-specific manner

    Gough, M., Delury, C. & Parkin, E., 2015, In : International Journal of Biochemistry Research and Review. 6, 1, p. 264-273 10 p.

    Research output: Contribution to journalJournal article

  9. Published

    The histidine composition of the amyloid-β domain, but not the E1 copper binding domain, modulates β-secretase processing of amyloid-β protein precursor in Alzheimer's disease

    Gough, M., Blanthorn-Hazell, S. & Parkin, E. T., 2015, In : Journal of Alzheimer's Disease. 43, 4, p. 1163-1168 6 p.

    Research output: Contribution to journalJournal article

  10. 2014
  11. Published

    The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells

    Gough, M., Blanthorn-Hazell, S., Delury, C. & Parkin, E., 31/10/2014, In : Biochemical and Biophysical Research Communications. 453, 4, p. 741-747 7 p.

    Research output: Contribution to journalJournal article

  12. 2013
  13. Published

    The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell lines

    Hicks, D. A., Makova, N. Z., Gough, M., Parkin, E. T., Nalivaeva, N. N. & Turner, A. J., 6/09/2013, In : Journal of Biological Chemistry. 288, 36, p. 26039-26051 13 p.

    Research output: Contribution to journalJournal article

  14. Published

    Differential regulation of E-cadherin expression by the soluble ectodomain and intracellular domain of jagged1

    Delury, C., Tinker, C., Rivers, S., Hodges, M., Broughton, S. & Parkin, E., 2/08/2013, In : International Journal of Biochemistry Research and Review. 3, 4, p. 278-290 13 p.

    Research output: Contribution to journalJournal article

  15. 2012
  16. Published

    Copper modulates zinc metalloproteinase-dependent ectodomain shedding of key signalling and adhesion proteins and promotes the invasion of prostate cancer epithelial cells

    Parr-Sturgess, C. A., Tinker, C. L., Hart, C. A., Brown, M. D., Clarke, N. W. & Parkin, E. T., 10/2012, In : Molecular Cancer Research. 10, 10, p. 1282-1293 12 p.

    Research output: Contribution to journalJournal article

  17. 2011
  18. Published

    Zinc metalloproteinases and amyloid Beta-Peptide metabolism: the positive side of proteolysis in Alzheimer's disease

    Gough, M., Parr-Sturgess, C. & Parkin, E., 2011, In : Biochemistry Research International. 2011, 13 p., 721463.

    Research output: Contribution to journalJournal article

  19. 2010
  20. Published

    Development of a proteolytically stable retro-inverso peptide inhibitor of β-amyloid oligomerization as a potential novel treatment for Alzheimer's disease

    Taylor, M., Moore, S., Mayes, J., Parkin, E., Beeg, M., Canovi, M., Gobbi, M., Mann, D. M. A. & Allsop, D., 2010, In : Biochemistry. 49, 15, p. 3261-3272 12 p.

    Research output: Contribution to journalJournal article

  21. Published

    Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event

    Parr-Sturgess, C. A., Rushton, D. J. & Parkin, E. T., 2010, In : Biochemical Journal. 432, 2, p. 283-294 12 p.

    Research output: Contribution to journalJournal article

  22. 2009
  23. Published

    Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein

    Harris, B., Pereira, I. & Parkin, E., 16/10/2009, In : Brain Research. 1296, n/a, p. 203-215 13 p.

    Research output: Contribution to journalJournal article

  24. Published

    Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein

    Taylor, D. R., Parkin, E. T., Cocklin, S. L., Ault, J. R., Ashcroft, A. E., Turner, A. J. & Hooper, N. M., 21/08/2009, In : Journal of Biological Chemistry. 284, 34, p. 22590-22600 11 p.

    Research output: Contribution to journalJournal article

  25. Published

    A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10

    Parkin, E. & Harris, B., 03/2009, In : Journal of Neurochemistry. 108, 6, p. 1464-1479 16 p.

    Research output: Contribution to journalJournal article

  26. 2008
  27. Published

    Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis

    Wilkinson, D. K., Turner, E. J., Parkin, E. T., Garner, A. E., Harrison, P. J., Crawford, M., Stewart, G. W. & Hooper, N. M., 01/2008, In : Biochimica et Biophysica Acta (BBA) - Biomembranes. 1778, 1, p. 125-132 8 p.

    Research output: Contribution to journalJournal article

  28. Published

    Alpha-Secretase and Alzheimer's disease

    Parkin, E., 2008, Recent advances in the biology of secretases, key proteases in Alzheimer's disease. Araki, W. (ed.). Research Signpost, p. 183-211 29 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter

  29. 2007
  30. Published

    Cellular pion protein regulates beta-secretase cleavage of the Alzheimers amyloid precurs protein.

    Parkin, E., Watt, N. T., Hussain, I., Eckman, E. A., Eckman, C. B., Manson, J. C., Baybutt, H. N., Turner, A. J. & Hooper, N. M., 26/06/2007, In : Proceedings of the National Academy of Sciences. 104, 26, p. 11062-11067 6 p.

    Research output: Contribution to journalJournal article

  31. 2005
  32. Published

    Angiotensin-converting enzyme as a GPlase : a critical reevaluation.

    Leisle, L., Parkin, E. T., Turner, A. J. & Hooper, N. M., 11/2005, In : Nature Medicine. 11, 11, p. 1139-1140 2 p.

    Research output: Contribution to journalJournal article

  33. Published

    Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2).

    Lambert, D. W., Yarski, M., Warner, F. J., Thornhill, P., Parkin, E. T., Smith, A. I., Hooper, N. M. & Turner, A. J., 26/08/2005, In : Journal of Biological Chemistry. 280, 34, p. 30113-30119 7 p.

    Research output: Contribution to journalJournal article

  34. Published

    Herpes simplex virus interferes with amyloid precursor protein processing.

    Shipley, S. J., Parkin, E. T., Itzhaki, R. F. & Dobson, C. B., 18/08/2005, In : BMC Microbiology. 5, p. 48

    Research output: Contribution to journalJournal article

  35. 2004
  36. Published

    The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein.

    Allinson, T. M. J., Parkin, E. T., Condon, T. P., Schwager, S. L. U., Sturrock, E. D., Turner, A. J. & Hooper, N. M., 06/2004, In : European Journal of Biochemistry. 271, 12, p. 2539-2547 9 p.

    Research output: Contribution to journalJournal article

  37. Published

    Dual Mechanisms for Shedding of the Cellular Prion Protein.

    Parkin, E. T., Watt, N. T., Turner, A. J. & Hooper, N. M., 19/03/2004, In : Journal of Biological Chemistry. 279, 12, p. 11170-11178 9 p.

    Research output: Contribution to journalJournal article

  38. Published

    Secretase-mediated cell surface shedding of the angiotensin-converting enzyme.

    Parkin, E. T., Turner, A. J. & Hooper, N. M., 2004, In : Protein and Peptide Letters. 11, p. 423-432 10 p.

    Research output: Contribution to journalJournal article

  39. 2003
  40. Published

    ADAMs family members as amyloid precursor protein -secretases.

    Allinson, T. M. J., Parkin, E. T., Turner, A. J. & Hooper, N. M., 1/11/2003, In : Journal of Neuroscience Research. 74, 3, p. 342-352 11 p.

    Research output: Contribution to journalJournal article

  41. Published

    The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts.

    Parkin, E. T., Tan, F., Skidgel, R. A., Turner, A. J. & Hooper, N. M., 1/08/2003, In : Journal of Cell Science. 116, 15, p. 3079-3087 9 p.

    Research output: Contribution to journalJournal article

  42. 2002
  43. Published

    Structure-Activity Relationship of Hydroxamate-Based Inhibitors on the Secretases that Cleave the Amyloid Precursor Protein, Angiotensin Converting Enzyme, CD23, and Pro-Tumor Necrosis Factor.

    Parkin, E. T., Trew, A., Christie, G., Faller, A., Mayer, R., Turner, A. J. & Hooper, N. M., 16/04/2002, In : Biochemistry. 41, 15, p. 4972-4981 10 p.

    Research output: Contribution to journalJournal article

  44. Published

    Inactivation of a tachykinin-related peptide: identification of four neuropeptide-degrading enzymes in neuronal membranes of insects from four different orders.

    Isaac, R. E., Parkin, E. T., Keen, J. N., Nässel, D. R., Siviter, R. J. & Shirras, A. D., 04/2002, In : Peptides. 23, 4, p. 725-733 9 p.

    Research output: Contribution to journalJournal article

  45. 2001
  46. Published

    Differential effects of glycosphingolipids on the detergent-insolubility of the glycosylphosphatidylinositol-anchored membrane dipeptidase.

    Parkin, E. T., Turner, A. J. & Hooper, N. M., 15/08/2001, In : Biochemical Journal. 358, 1, p. 209-216 8 p.

    Research output: Contribution to journalJournal article

  47. Published

    A Point Mutation in the Juxtamembrane Stalk of Human Angiotensin I-converting Enzyme Invokes the Action of a Distinct Secretase.

    Alfalah, M., Parkin, E. T., Jacob, R., Sturrock, E. D., Mentele, R., Turner, A. J., Hooper, N. M. & Naim, H. Y., 15/06/2001, In : Journal of Biological Chemistry. 276, 24, p. 21105-21109 5 p.

    Research output: Contribution to journalJournal article

  48. 2000
  49. Published

    The Alzheimer's amyloid precursor protein a-secretase and the angiotensin converting enzyme secretase exhibit closely related enzyme activities.

    Parkin, E. T., Turner, A. J. & Hooper, N. M., 2000.

    Research output: Contribution to conference - Without ISBN/ISSN Other

  50. Published

    The role of proteolysis in Alzheimer's disease.

    Hooper, N. M., Trew, A. J., Parkin, E. T. & Turner, A. J., 2000, Cellular peptidases in immune functions and diseases. Langner, J. & Ansorge, S. (eds.). Plenum, p. 379-390 12 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter

  51. 1999
  52. Published

    Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein.

    Parkin, E. T., Turner, A. J. & Hooper, N. M., 15/11/1999, In : Biochemical Journal. 344, 1, p. 23-30 8 p.

    Research output: Contribution to journalJournal article

  53. Published

    Caveolae-like membranes and the amyloid precursor protein : a critical reassessment.

    Parkin, E. T., Turner, A. J. & Hooper, N. M., 06/1999, In : Journal of Neurochemistry. 72, Supple, p. S71

    Research output: Contribution to journalJournal article

  54. Published

    Characterization of Detergent-Insoluble Complexes Containing the Familial Alzheimer's Disease-Associated Presenilins.

    Parkin, E. T., Hussain, I., Karran, E. H., Turner, A. J. & Hooper, N. M., 04/1999, In : Journal of Neurochemistry. 72, 4, p. 1534-1543 10 p.

    Research output: Contribution to journalJournal article

  55. Published

    Modulation of phosphatidylcholine biosynthesis in celery by exogenous fatty acids.

    Parkin, E. T. & Rolphe, C. E., 15/01/1999, In : Phytochemistry. 50, 1, p. 47-51 5 p.

    Research output: Contribution to journalJournal article

  56. Published

    Caveolae-like membranes and the amyloid precursor protein : a critical reassessment.

    Parkin, E. T., Turner, A. J. & Hooper, N. M., 1999, In : British Neuroscience Association Abstracts. 15, p. 59

    Research output: Contribution to journalJournal article

  57. Published

    Distribution of presenilins and amyloid precursor protein in detergent-insoluble membrane domains.

    Parkin, E. T., Turner, A. J. & Hooper, N. M., 1999, Alzheimer's disease : methods and protocols. Walker, J. M. (ed.). Humana Press, p. 345-360 16 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter

  58. Published

    Distribution of presenilins and amyloid precursor protein in detergent-insoluble membrane microdomains

    Parkin, E., Turner, A. & Hooper, N., 1999, Alzheimer's disease: methods and protocols. Hooper, N. M. (ed.). Humana Press, p. 345-360 16 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter

  59. 1997
  60. Published

    The amyloid precursor protein is not enriched in caveolae-like, detergent-insoluble membrane microdomains

    Parkin, E., Hussain, I., Turner, A. J. & Hooper, N. M., 11/1997, In : Journal of Neurochemistry. 69, 5, p. 2179-2188 10 p.

    Research output: Contribution to journalJournal article

  61. 1996
  62. Published

    A role for calcium and annexins in the formation of caveolae

    Parkin, E., Turner, A. J. & Hooper, N. M., 08/1996, In : Biochemical Society Transactions. 24, 3, p. 444S 1 p.

    Research output: Contribution to journalJournal article

  63. Published

    Glycosylation and glycosylphosphatidylinositol membrane anchors

    Turner, A., Parkin, E. & Hooper, N., 1996, Regulatory protein modification: techniques and protocols. Hemmings, H. C. (ed.). Humana Press, Vol. 30. p. 395-427 33 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter

  64. Published

    Isolation and characterization of two distinct low-density, Triton-insoluble, complexes from porcine lung membranes

    Parkin, E., Turner, A. J. & Hooper, N. M., 1996, In : Biochemical Journal. 319 , 3, p. 887-896 10 p.

    Research output: Contribution to journalJournal article

  65. 1995
  66. Published

    Phoshatidylcholine biosynthesis and cell growth in Apium graveolens

    Parkin, E. & Rolph, C., 08/1995, In : Physiologia Plantarum. 94, 4, p. 643-650 8 p.

    Research output: Contribution to journalJournal article

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