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Research

Dr Eleri Hughes

Formerly at Lancaster University

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  1. 2020
  2. E-pub ahead of print

    Circular dichroism spectroscopy identifies the β-adrenoceptor agonist salbutamol as a direct inhibitor of tau filament formation in vitro.

    Middleton, D., Townsend, D., Hughes, E., Fullwood, N., Siligardi, G., Hussain, R. & Mala, B., 10/06/2020, (E-pub ahead of print) In: ACS Chemical Neuroscience.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. 2019
  4. Published

    Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR

    Lau, S., Griffin, J., Hughes, E. & Middleton, D., 14/11/2019, In: Chemical Communications. 55, 88, p. 13287-13290 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. 2018
  6. Published

    Orientation of a Diagnostic Ligand Bound to Macroscopically Aligned Amyloid-β Fibrils Determined by Solid-State NMR

    Townsend, D. J., Hughes, E., Stewart, K., Griffin, J. M., Radford, S. & Middleton, D. A., 15/11/2018, In: The Journal of Physical Chemistry Letters. 9, 22, p. 6611–6615 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin

    Townsend, D., Hughes, E., Akien, G., Stewart, K. L., Radford, S. E., Rochester, D. & Middleton, D. A., 17/08/2018, In: Journal of Biological Chemistry. 293, 33, p. 12877-12893 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Average orientation of a fluoroaromatic molecule in lipid bilayers from DFT-informed NMR measurements of 1H-19F dipolar couplings

    Hughes, E., Griffin, J. M., Coogan, M. P. & Middleton, D. A., 21/07/2018, In: Physical Chemistry Chemical Physics. 20, 27, p. 18207-18215 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. 2017
  10. Published

    Molecular Origins of the Compatibility Between Glycosaminoglycans and Aβ40 Amyloid Fibrils

    Stewart, K. L., Hughes, E., Yates, E. A., Middleton, D. A. & Radford, S. E., 4/08/2017, In: Journal of Molecular Biology. 429, 16, p. 2449-2462 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    Heparin and methionine oxidation promote the formation of apolipoprotein A-I amyloid comprising α-helical and β-sheet structures.

    Townsend, D. J., Hughes, E., Hussain, R., Siligardi, G., Baldock, S. J., Madine, J. & Middleton, D. A., 21/03/2017, In: Biochemistry. 56, 11, p. 1632-1644 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. 2016
  13. Published

    Atomic details of the interactions of Glycosaminoglycans with amyloid-β fibrils

    Stewart, K., Hughes, E., Yates, E., Akien, G. R., Huang, T-Y., Lima, M., Rudd, T., Guerrini, M., Hung, S-C., Radford, S. & Middleton, D. A., 13/07/2016, In: Journal of the American Chemical Society. 138, 27, p. 8328-8331 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    Novel stereoselective bufadienolides reveal new insights into the requirements for Na+, K+-ATPase inhibition by cardiotonic steroids

    Tang, H-J., Ruan, L-J., Tian, H-Y., Liang, G-P., Ye, W-C., Hughes, E., Esmann, M., Fedosova, N. U., Chung, T-Y., Tzen, J. T. C., Jiang, R-W. & Middleton, D. A., 5/07/2016, In: Scientific Reports. 2016, 6, 10 p., 29155.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. 2014
  16. Published

    Comparison of the structure and function of phospholamban and the Arginine-14 deficient mutant associated with dilated cardiomyopathy

    Hughes, E. & Middleton, D. A., 16/09/2014, In: PLoS ONE. 9, 9, 10 p., 106746.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. 2013
  18. Published

    Heparin promotes the rapid fibrillization of a peptide with low intrinsic amyloidogenicity

    Madine, J., Davies, H. A., Hughes, E. & Middleton, D. A., 17/12/2013, In: Biochemistry. 52, 50, p. 8984-8992 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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