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Geoffrey Akien

  • Chemistry
Postal address:
Department of Chemistry

Email: g.akien@lancaster.ac.uk

Phone: +44 1524 593790

Professional Role

I run the solution state NMR facility in the Department of Chemistry at Lancaster: currently a Bruker Fourier 300 and an Avance III 400.  I also play a supporting role for the solid state NMR facility: a Bruker Avance III HD 400WB and 700WB.

I maintain the instruments and the supporting infrastructure, and provide training and advice on everything from sample preparation through to data analysis.  If you have any questions, just ask!

SUMMARY of research interests (100 words)

I have a broad interest in the use of NMR for the characterisation of complex mixtures and unstable intermediates.

Research output

Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin

Townsend, D., Hughes, E., Akien, G., Stewart, K. L., Radford, S. E., Rochester, D. & Middleton, D. A. 17/08/2018 In : Journal of Biological Chemistry. 293, 33, p. 12877-12893 17 p.

Enhanced process development using automated continuous reactors by self-optimisation algorithms and statistical empirical modelling

Jeraal, M. I., Holmes, N., Akien, G. R. & Bourne, R. A. 21/06/2018 In : Tetrahedron. 74, 25, p. 3158-3164 7 p.

Self-assembly of singlet-emitting double-helical silver dimers: the curious coordination chemistry and fluorescence of bisquinolylpyridone

Farrow, C., Halcovitch, N. R., Akien, G. R., Platts, J. A. & Coogan, M. P. 21/03/2018 In : Dalton Transactions. 47, 11, p. 3906-3912 7 p.

Dinucleating Schiff base ligand in Zn/4f coordination chemistry: synthetic challenges and catalytic activity evaluation

Sampani, S. I., Aubert, S., Cattoen, M., Griffiths, K., Abdul-Sada, A., Akien, G. R., Tizzard, G. J., Coles, S. J., Arseniyadis, S. & Kostakis, G. E. 23/02/2018 In : Dalton Transactions.

Rapid and simultaneous synthesis of a hydrogen bond template [3]rotaxane and its related [2]rotaxane molecular shuttle

Evans, N. H. & Akien, G. R. 02/2018 In : Supramolecular Chemistry. 30, 2, p. 158-164 7 p.

3d/4f Coordination Clusters as Cooperative Catalysts for Highly Diastereoselective Michael Addition Reactions

Griffiths, K., Tsipis, A. C., Kumar, P., Townrow, O. P. E., Abdul-Sada, A., Akien, G. R., Baldansuren, A., Spivey, A. C. & Kostakis, G. E. 21/08/2017 In : Inorganic Chemistry. 56, 16, p. 9563-9573 11 p.

Intensified and safe ozonolysis of fatty acid methyl esters in liquid CO2 in a continuous reactor

Lundin, M. D., Danby, A. M., Akien, G. R., Venkitasubramanian, P., Martin, K. J., Busch, D. H. & Subramaniam, B. 07/2017 In : AIChE Journal. 63, 7, p. 2819-2826 8 p.

Rapid multistep kinetic model generation from transient flow data

Hone, C. A., Holmes, N., Akien, G. R., Bourne, R. A. & Muller, F. L. 1/04/2017 In : Reaction Chemistry and Engineering. 2, 2, p. 103-108 6 p.

[N,N-Bis(2-hy­droxy­eth­yl)di­thio­carbamato-[kappa]2S,S']bis­(tri­phenyl­phosphane-[kappa]P)copper(I) chloro­form monosolvate: crystal structure, Hirshfeld surface analysis and solution NMR measurements

Tan, S. L., Yeo, C. I., Heard, P. J., Akien, G. R., Halcovitch, N. R. & Tiekink, E. R. T. 12/2016 In : Acta Crystallographica Section E: Crystallographic Communications. 72, 12, p. 1799-1805 7 p.

Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor

Holmes, N., Akien, G. R., Blacker, A. J., Woodward, R. L., Meadows, R. E. & Bourne, R. A. 1/08/2016 In : Reaction Chemistry and Engineering. 1, 4, p. 366-371 6 p.

Atomic details of the interactions of Glycosaminoglycans with amyloid-β fibrils

Stewart, K., Hughes, E., Yates, E., Akien, G. R., Huang, T-Y., Lima, M., Rudd, T., Guerrini, M., Hung, S-C., Radford, S. & Middleton, D. A. 13/07/2016 In : Journal of the American Chemical Society. 138, 27, p. 8328-8331 4 p.

Tetranuclear Zn/4f coordination clusters as highly efficient catalysts for Friedel–Crafts alkylation

Griffiths, K., Kumar, P., Akien, G. R., Chilton, N. F., Abdul-Sada, A., Tizzard, G. J., Coles, S. J. & Kostakis, G. E. 25/06/2016 In : Chemical Communications. 52, 50, p. 7866-7869 4 p.

Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

Holmes, N., Akien, G. R., Savage, R. J. D., Stanetty, C., Baxendale, I. R., Blacker, A. J., Taylor, B. A., Woodward, R. L., Meadows, R. E. & Bourne, R. A. 2016 In : Reaction Chemistry and Engineering. 2016, 1, p. 96-100 5 p.

Liquid CO2 as a safe and benign solvent for the ozonolysis of fatty acid methyl esters

Akien, G. R., Lundin, M. D., Danby, A. M., Binder, T. P., Busch, D. H. & Subramaniam, B. 7/12/2015 In : ACS Sustainable Chemistry & Engineering. 3, 12, p. 3307-3314 8 p.

Continuous hydroformylation with phosphine-functionalized polydimethylsiloxane rhodium complexes as nanofilterable homogeneous catalysts

Xie, Z., Akien, G. R., Sarkar, B. R., Subramaniam, B. & Chaudhari, R. V. 14/10/2015 In : Industrial and Engineering Chemistry Research. 54, 43, p. 10656-10660 5 p.

Definition and application of ethanol equivalent: sustainability performance metrics for biomass conversion to carbon-based fuels and chemicals

Csefalvay, E., Akien, G. R., Qi, L. & Horvath, I. T. 1/01/2015 In : Catalysis Today. 239, p. 50-55 6 p.

Supercritical fluids and gas-expanded liquids as tunable media for multiphase catalytic reactions

Subramaniam, B., Chaudhari, R. V., Chaudhari, A. S., Akien, G. R. & Xie, Z. 1/08/2014 In : Chemical Engineering Science. 115, p. 3-18 16 p.

Catalytic conversion of fructose, glucose, and sucrose to 5-(hydroxymethyl)furfural and levulinic and formic acids in gamma-valerolactone as a green solvent

Qi, L., Mui, Y. F., Lo, S. W., Lui, M. Y., Akien, G. R. & Horvath, I. T. 05/2014 In : ACS Catalysis. 4, 5, p. 1470-1477 8 p.

Sustainable catalytic reaction engineering with gas-expanded liquids

Subramaniam, B. & Akien, G. R. 1/08/2012 In : Current Opinion in Chemical Engineering. 1, 3, p. 336-341 6 p.

Synthesis in Green Solvents

Orha, L., Akien, G. & Horvath, I. T. 15/04/2012 Handbook of Green Chemistry: Online. Wiley-VCH, Vol. 7

Molecular mapping of the acid catalysed dehydration of fructose

Akien, G. R., Qi, L. & Horvath, I. T. 2012 In : Chemical Communications. 48, 47, p. 5850-5852 3 p.

Self-optimizing continuous reactions in supercritical carbon dioxide

Parrott, A. J., Bourne, R. A., Akien, G. R., Irvine, D. J. & Poliakoff, M. 11/04/2011 In : Angewandte Chemie International Edition. 50, 16, p. 3788-3792 5 p.

Detecting phase transitions in supercritical mixtures: an enabling tool for greener chemical reactions

Ke, J., Sanchez-Vicente, Y., Akien, G. R., Novitskiy, A. A., Comak, G., Bagratashvili, V. N., George, M. W. & Poliakoff, M. 8/10/2010 In : Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences. 466, 2122, p. 2799-2818 20 p.

Pressure drop as a simple method for locating phase transitions in continuous flow high pressure reactors

Akien, G. R., Skilton, R. A. & Poliakoff, M. 19/05/2010 In : Industrial and Engineering Chemistry Research. 49, 10, p. 4974-4980 7 p.

Continuous heterogeneous catalytic oxidation of primary and secondary alcohols in scCO(2)

Chapman, A. O., Akien, G. R., Arrowsmith, N. J., Licence, P. & Poliakoff, M. 2010 In : Green Chemistry. 12, 2, p. 310-315 6 p.

Conversion of carbohydrates to liquid fuels

Akien, G., Qi, L. & Horváth, I. T. 2010 Thermochemical Conversion of Biomass to Liquid Fuels and Chemicals. Crocker, M. (ed.). Cambridge: RSC Publishing, p. 365-381 17 p.

The continuous catalytic debenzylation of 1,4-Dibenzyloxybenzene with H-2 in THF expanded with high pressure CO2

Akien, G. R., Legeay, J-C., Wells, A. & Poliakoff, M. 2010 In : Organic Process Research and Development. 14, 5, p. 1202-1208 7 p.

A critical look at reactions in class I and II gas-expanded liquids using CO2 and other gases

Akien, G. R. & Poliakoff, M. 2009 In : Green Chemistry. 11, 8, p. 1083-1100 18 p.