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Dr Geoffrey Akien

Experimental Officer (NMR)

  1. 2018
  2. Published

    Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin

    Townsend, D., Hughes, E., Akien, G., Stewart, K. L., Radford, S. E., Rochester, D. & Middleton, D. A. 17/08/2018 In : Journal of Biological Chemistry. 293, 33, p. 12877-12893 17 p.

    Research output: Contribution to journalJournal article

  3. Published

    Enhanced process development using automated continuous reactors by self-optimisation algorithms and statistical empirical modelling

    Jeraal, M. I., Holmes, N., Akien, G. R. & Bourne, R. A. 21/06/2018 In : Tetrahedron. 74, 25, p. 3158-3164 7 p.

    Research output: Contribution to journalJournal article

  4. Published

    Self-assembly of singlet-emitting double-helical silver dimers: the curious coordination chemistry and fluorescence of bisquinolylpyridone

    Farrow, C., Halcovitch, N. R., Akien, G. R., Platts, J. A. & Coogan, M. P. 21/03/2018 In : Dalton Transactions. 47, 11, p. 3906-3912 7 p.

    Research output: Contribution to journalJournal article

  5. E-pub ahead of print

    Dinucleating Schiff base ligand in Zn/4f coordination chemistry: synthetic challenges and catalytic activity evaluation

    Sampani, S. I., Aubert, S., Cattoen, M., Griffiths, K., Abdul-Sada, A., Akien, G. R., Tizzard, G. J., Coles, S. J., Arseniyadis, S. & Kostakis, G. E. 23/02/2018 In : Dalton Transactions.

    Research output: Contribution to journalJournal article

  6. Published

    Rapid and simultaneous synthesis of a hydrogen bond template [3]rotaxane and its related [2]rotaxane molecular shuttle

    Evans, N. H. & Akien, G. R. 02/2018 In : Supramolecular Chemistry. 30, 2, p. 158-164 7 p.

    Research output: Contribution to journalJournal article

  7. 2017
  8. Published

    3d/4f Coordination Clusters as Cooperative Catalysts for Highly Diastereoselective Michael Addition Reactions

    Griffiths, K., Tsipis, A. C., Kumar, P., Townrow, O. P. E., Abdul-Sada, A., Akien, G. R., Baldansuren, A., Spivey, A. C. & Kostakis, G. E. 21/08/2017 In : Inorganic Chemistry. 56, 16, p. 9563-9573 11 p.

    Research output: Contribution to journalJournal article

  9. Published

    Intensified and safe ozonolysis of fatty acid methyl esters in liquid CO2 in a continuous reactor

    Lundin, M. D., Danby, A. M., Akien, G. R., Venkitasubramanian, P., Martin, K. J., Busch, D. H. & Subramaniam, B. 07/2017 In : AIChE Journal. 63, 7, p. 2819-2826 8 p.

    Research output: Contribution to journalJournal article

  10. Published

    Rapid multistep kinetic model generation from transient flow data

    Hone, C. A., Holmes, N., Akien, G. R., Bourne, R. A. & Muller, F. L. 1/04/2017 In : Reaction Chemistry and Engineering. 2, 2, p. 103-108 6 p.

    Research output: Contribution to journalJournal article

  11. 2016
  12. Published

    [N,N-Bis(2-hy­droxy­eth­yl)di­thio­carbamato-[kappa]2S,S']bis­(tri­phenyl­phosphane-[kappa]P)copper(I) chloro­form monosolvate: crystal structure, Hirshfeld surface analysis and solution NMR measurements

    Tan, S. L., Yeo, C. I., Heard, P. J., Akien, G. R., Halcovitch, N. R. & Tiekink, E. R. T. 12/2016 In : Acta Crystallographica Section E: Crystallographic Communications. 72, 12, p. 1799-1805 7 p.

    Research output: Contribution to journalJournal article

  13. Published

    Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor

    Holmes, N., Akien, G. R., Blacker, A. J., Woodward, R. L., Meadows, R. E. & Bourne, R. A. 1/08/2016 In : Reaction Chemistry and Engineering. 1, 4, p. 366-371 6 p.

    Research output: Contribution to journalJournal article

  14. Published

    Atomic details of the interactions of Glycosaminoglycans with amyloid-β fibrils

    Stewart, K., Hughes, E., Yates, E., Akien, G. R., Huang, T-Y., Lima, M., Rudd, T., Guerrini, M., Hung, S-C., Radford, S. & Middleton, D. A. 13/07/2016 In : Journal of the American Chemical Society. 138, 27, p. 8328-8331 4 p.

    Research output: Contribution to journalJournal article

  15. Published

    Tetranuclear Zn/4f coordination clusters as highly efficient catalysts for Friedel–Crafts alkylation

    Griffiths, K., Kumar, P., Akien, G. R., Chilton, N. F., Abdul-Sada, A., Tizzard, G. J., Coles, S. J. & Kostakis, G. E. 25/06/2016 In : Chemical Communications. 52, 50, p. 7866-7869 4 p.

    Research output: Contribution to journalJournal article

  16. Published

    Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

    Holmes, N., Akien, G. R., Savage, R. J. D., Stanetty, C., Baxendale, I. R., Blacker, A. J., Taylor, B. A., Woodward, R. L., Meadows, R. E. & Bourne, R. A. 2016 In : Reaction Chemistry and Engineering. 2016, 1, p. 96-100 5 p.

    Research output: Contribution to journalJournal article

  17. 2015
  18. Published

    Liquid CO2 as a safe and benign solvent for the ozonolysis of fatty acid methyl esters

    Akien, G. R., Lundin, M. D., Danby, A. M., Binder, T. P., Busch, D. H. & Subramaniam, B. 7/12/2015 In : ACS Sustainable Chemistry & Engineering. 3, 12, p. 3307-3314 8 p.

    Research output: Contribution to journalJournal article

  19. Published

    Continuous hydroformylation with phosphine-functionalized polydimethylsiloxane rhodium complexes as nanofilterable homogeneous catalysts

    Xie, Z., Akien, G. R., Sarkar, B. R., Subramaniam, B. & Chaudhari, R. V. 14/10/2015 In : Industrial and Engineering Chemistry Research. 54, 43, p. 10656-10660 5 p.

    Research output: Contribution to journalJournal article

  20. Published

    Definition and application of ethanol equivalent: sustainability performance metrics for biomass conversion to carbon-based fuels and chemicals

    Csefalvay, E., Akien, G. R., Qi, L. & Horvath, I. T. 1/01/2015 In : Catalysis Today. 239, p. 50-55 6 p.

    Research output: Contribution to journalJournal article

  21. 2014
  22. Published

    Supercritical fluids and gas-expanded liquids as tunable media for multiphase catalytic reactions

    Subramaniam, B., Chaudhari, R. V., Chaudhari, A. S., Akien, G. R. & Xie, Z. 1/08/2014 In : Chemical Engineering Science. 115, p. 3-18 16 p.

    Research output: Contribution to journalJournal article

  23. Published

    Catalytic conversion of fructose, glucose, and sucrose to 5-(hydroxymethyl)furfural and levulinic and formic acids in gamma-valerolactone as a green solvent

    Qi, L., Mui, Y. F., Lo, S. W., Lui, M. Y., Akien, G. R. & Horvath, I. T. 05/2014 In : ACS Catalysis. 4, 5, p. 1470-1477 8 p.

    Research output: Contribution to journalJournal article

  24. Published

    Generation and characterization of the pyranosyl and furanosyl oxocarbenium ions from 2-deoxyaldoses

    Akien, G. & Subramaniam, B. 20/03/2014

    Research output: Contribution to conference Abstract

  25. 2013
  26. Published
  27. Published

    Mechanistic studies on the dehydration of glucose to 5-hydroxymethylfurfural and xylose to furfural

    Akien, G., Qi, L. & Horvath, I. T. 10/04/2013

    Research output: Contribution to conference Abstract

  28. 2012
  29. Published

    Sustainable catalytic reaction engineering with gas-expanded liquids

    Subramaniam, B. & Akien, G. R. 1/08/2012 In : Current Opinion in Chemical Engineering. 1, 3, p. 336-341 6 p.

    Research output: Contribution to journalJournal article

  30. Published

    Synthesis in Green Solvents

    Orha, L., Akien, G. & Horvath, I. T. 15/04/2012 Handbook of Green Chemistry: Online. Wiley-VCH, Vol. 7

    Research output: Contribution in Book/Report/ProceedingsChapter (peer-reviewed)

  31. Published

    Molecular mapping of the acid catalysed dehydration of fructose

    Akien, G. R., Qi, L. & Horvath, I. T. 2012 In : Chemical Communications. 48, 47, p. 5850-5852 3 p.

    Research output: Contribution to journalJournal article

  32. 2011
  33. Published

    Self-optimizing continuous reactions in supercritical carbon dioxide

    Parrott, A. J., Bourne, R. A., Akien, G. R., Irvine, D. J. & Poliakoff, M. 11/04/2011 In : Angewandte Chemie International Edition. 50, 16, p. 3788-3792 5 p.

    Research output: Contribution to journalJournal article

  34. Published

    Sustainable synthesis of gamma-valerolactone

    Horvath, I. T., Qi, L. & Akien, G. R. 27/03/2011 In : Abstracts of Papers of the American Chemical Society. 241, 1 p.

    Research output: Contribution to journalMeeting abstract

  35. 2010
  36. Published

    Detecting phase transitions in supercritical mixtures: an enabling tool for greener chemical reactions

    Ke, J., Sanchez-Vicente, Y., Akien, G. R., Novitskiy, A. A., Comak, G., Bagratashvili, V. N., George, M. W. & Poliakoff, M. 8/10/2010 In : Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences. 466, 2122, p. 2799-2818 20 p.

    Research output: Contribution to journalLiterature review

  37. Published

    Pressure drop as a simple method for locating phase transitions in continuous flow high pressure reactors

    Akien, G. R., Skilton, R. A. & Poliakoff, M. 19/05/2010 In : Industrial and Engineering Chemistry Research. 49, 10, p. 4974-4980 7 p.

    Research output: Contribution to journalJournal article

  38. Published

    Continuous heterogeneous catalytic oxidation of primary and secondary alcohols in scCO(2)

    Chapman, A. O., Akien, G. R., Arrowsmith, N. J., Licence, P. & Poliakoff, M. 2010 In : Green Chemistry. 12, 2, p. 310-315 6 p.

    Research output: Contribution to journalJournal article

  39. Published

    Conversion of carbohydrates to liquid fuels

    Akien, G., Qi, L. & Horváth, I. T. 2010 Thermochemical Conversion of Biomass to Liquid Fuels and Chemicals. Crocker, M. (ed.). Cambridge: RSC Publishing, p. 365-381 17 p.

    Research output: Contribution in Book/Report/ProceedingsChapter (peer-reviewed)

  40. Published

    The continuous catalytic debenzylation of 1,4-Dibenzyloxybenzene with H-2 in THF expanded with high pressure CO2

    Akien, G. R., Legeay, J-C., Wells, A. & Poliakoff, M. 2010 In : Organic Process Research and Development. 14, 5, p. 1202-1208 7 p.

    Research output: Contribution to journalJournal article

  41. 2009
  42. Published

    A critical look at reactions in class I and II gas-expanded liquids using CO2 and other gases

    Akien, G. R. & Poliakoff, M. 2009 In : Green Chemistry. 11, 8, p. 1083-1100 18 p.

    Research output: Contribution to journalLiterature review

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