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Professor Joanne Knight

Chair in Applied Data Science

  1. 2018
  2. Published

    Heritability estimates of cortical anatomy: The influence and reliability of different estimation strategies

    Patel, S., Patel, R., Park, M. T. M., Masellis, M., Knight, J. & Chakravarty, M. M. 09/2018 In : NeuroImage. 178, p. 78-91 14 p.

    Research output: Contribution to journalJournal article

  3. Published

    Age at first birth in women is genetically associated with increased risk of schizophrenia

    Ni, G., Gratten, J., Wray, N. R., Lee, S. H., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium 5/07/2018 In : Scientific Reports. 8, 1, 14 p., 10168

    Research output: Contribution to journalJournal article

  4. Published

    Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

    Knight, J. & Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium 14/06/2018 In : Cell. 173, 7, p. 1705-1715.e16 11 p.

    Research output: Contribution to journalJournal article

  5. Published

    Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood

    Ni, G., Moser, G., Wray, N. R., Lee, S. H., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium 7/06/2018 In : American Journal of Human Genetics. 102, 6, p. 1185-1194 10 p.

    Research output: Contribution to journalJournal article

  6. Published

    A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia

    Li, W., Fan, C. C., Mäki-Marttunen, T., Thompson, W. K., Schork, A. J., Bettella, F., Djurovic, S., Dale, A. M., Andreassen, O. A., Wang, Y., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium 06/2018 In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 177, 4, p. 454-467 14 p.

    Research output: Contribution to journalJournal article

  7. E-pub ahead of print

    APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies

    Saeed, U., Mirza, S. S., MacIntosh, B. J., Herrmann, N., Keith, J., Ramirez, J., Nestor, S. M., Yu, Q., Knight, J., Swardfager, W., Potkin, S. G., Rogaeva, E., George-Hyslop, P. S., Black, S. E. & Masellis, M. 18/05/2018 In : Alzheimer's and Dementia.

    Research output: Contribution to journalJournal article

  8. Published

    Profiling Medical Journal Articles Using a Gene Ontology Semantic Tagger

    El Haj, M., Rayson, P. E., Piao, S. S. & Knight, J. 11/05/2018 LREC 2018, Eleventh International Conference on Language Resources and Evaluation. Calzolari, N., Choukri, K., Cieri, C., Declerck, T., Goggi, S., Hasida, K., Isahara, H., Maegaard, B., Mariani, J., Mazo, H., Moreno, A., Odijk, J., Piperidis, S. & Tokunaga, T. (eds.). European Language Resources Association (ELRA), p. 4593-4597 5 p.

    Research output: Contribution in Book/Report/ProceedingsConference contribution

  9. Published

    Connected Health Cities – Lancaster – the north west coast and beyond

    Knight, J. & King, N. S. 23/04/2018 In : Morecambe Bay Medical Journal. 7, 12, p. 310-310 1 p.

    Research output: Contribution to journalJournal article

  10. Published

    Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

    Gusev, A., Mancuso, N., Won, H., Kousi, M., Finucane, H. K., Reshef, Y., Song, L., Safi, A., McCarroll, S., Neale, B. M., Ophoff, R. A., O'Donovan, M. C., Crawford, G. E., Geschwind, D. H., Katsanis, N., Sullivan, P. F., Pasaniuc, B., Price, A. L., Schizophrenia Working Group of the Psychiatric Genomics Consortium & Knight, J. 04/2018 In : Nature Genetics. 50, 4, p. 538-548 11 p.

    Research output: Contribution to journalJournal article

  11. Published

    Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences

    Chenoweth, M. J., Ware, J. J., Zhu, A. Z. X., Cole, C. B., Cox, L. S., Nollen, N., Ahluwalia, J. S., Benowitz, N. L., Schnoll, R. A., Hawk, L. W., Cinciripini, P. M., George, T. P., Lerman, C., Knight, J., Tyndale, R. F. & PGRN-PNAT Research Group 03/2018 In : Addiction. 113, 3, p. 509-523 15 p.

    Research output: Contribution to journalJournal article

  12. Published

    Examining the role of common and rare mitochondrial variants in schizophrenia

    Gonçalves, V. F., Giamberardino, S. N., Crowley, J. J., Vawter, M. P., Saxena, R., Bulik, C. M., Yilmaz, Z., Hultman, C. M., Sklar, P., Kennedy, J. L., Sullivan, P. F. & Knight, J. 25/01/2018 In : PLoS ONE. 13, 1, e0191153

    Research output: Contribution to journalJournal article

  13. Published

    Unraveling DNA sequence to identify cerebral indicators of dementia risk

    Masellis, M. & Knight, J. 16/01/2018 In : Neurology. 90, 3, p. 109 1 p.

    Research output: Contribution to journalComment/debate

  14. 2017
  15. E-pub ahead of print

    Can we accurately classify schizophrenia patients from healthy controls using magnetic resonance imaging and machine learning?: A multi-method and multi-dataset study

    Winterburn, J. L., Voineskos, A. N., Devenyi, G. A., Plitman, E., de la Fuente-Sandoval, C., Bhagwat, N., Graff-Guerrero, A., Knight, J. & Chakravarty, M. M. 21/12/2017 In : Schizophrenia Research.

    Research output: Contribution to journalJournal article

  16. Published

    Genetic epistasis regulates amyloid deposition in resilient aging

    Felsky, D., Xu, J., Chibnik, L., Schneider, J., Knight, J., Kennedy, J. L., Bennett, D. A., De Jager, P. L. & Voineskos, A. N. 10/2017 In : Alzheimer's and Dementia. 13, 10, p. 1107-1116 10 p.

    Research output: Contribution to journalJournal article

  17. Published
  18. Published

    Heritability of hippocampal subfield volumes using a twin and non-twin siblings design

    Patel, S., Park, M. T. M., Devenyi, G. A., Patel, R., Masellis, M., Knight, J. & Chakravarty, M. M. 09/2017 In : Human Brain Mapping. 38, 9, p. 4337-4352 16 p.

    Research output: Contribution to journalJournal article

  19. Published

    Fine-mapping inflammatory bowel disease loci to single-variant resolution

    Huang, H. , Fang, M. , Jostins, L. , Umićević Mirkov, M. , Boucher, G. , Anderson, C. A. , Andersen, V. , Cleynen, I. , Cortes, A. , Crins, F. , D'Amato, M. , Deffontaine, V. , Dmitrieva, J. , Docampo, E. , Elansary, M. , Farh, K. K-H. , Franke, A. , Gori, A-S. , Goyette, P. , Halfvarson, J. & 27 others Haritunians, T., Knight, J., Lawrance, I. C., Lees, C. W., Louis, E., Mariman, R., Meuwissen, T., Mni, M., Momozawa, Y., Parkes, M., Spain, S. L., Théâtre, E., Trynka, G., Satsangi, J., van Sommeren, S., Vermeire, S., Xavier, R. J., Weersma, R. K., Duerr, R. H., Mathew, C. G., Rioux, J. D., McGovern, D. P. B., Cho, J. H., Georges, M., Daly, M. J., Barrett, J. C. & International Inflammatory Bowel Disease Genetics Consortium 13/07/2017 In : Nature. 547, 7662, p. 173-178 6 p.

    Research output: Contribution to journalJournal article

  20. Published

    Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

    Witt, S. H. , Streit, F. , Jungkunz, M. , Frank, J. , Awasthi, S. , Reinbold, C. S. , Treutlein, J. , Degenhardt, F. , Forstner, A. J. , Heilmann-Heimbach, S. , Dietl, L. , Schwarze, C. E. , Schendel, D. , Strohmaier, J. , Abdellaoui, A. , Adolfsson, R. , Air, T. M. , Akil, H. , Alda, M. , Alliey-Rodriguez, N. & 136 others Andreassen, O. A., Babadjanova, G., Bass, N. J., Bauer, M., Baune, B. T., Bellivier, F., Bergen, S., Bethell, A., Biernacka, J. M., Blackwood, D. H. R., Boks, M. P., Boomsma, D. I., Børglum, A. D., Borrmann-Hassenbach, M., Brennan, P., Budde, M., Buttenschøn, H. N., Byrne, E. M., Cervantes, P., Clarke, T-K., Craddock, N., Cruceanu, C., Curtis, D., Czerski, P. M., Dannlowski, U., Davis, T., de Geus, E. J. C., Di Florio, A., Djurovic, S., Domenici, E., Edenberg, H. J., Etain, B., Fischer, S. B., Forty, L., Fraser, C., Frye, M. A., Fullerton, J. M., Gade, K., Gershon, E. S., Giegling, I., Gordon, S. D., Gordon-Smith, K., Grabe, H. J., Green, E. K., Greenwood, T. A., Grigoroiu-Serbanescu, M., Guzman-Parra, J., Hall, L. S., Hamshere, M., Hauser, J., Hautzinger, M., Heilbronner, U., Herms, S., Hitturlingappa, S., Hoffmann, P., Holmans, P., Hottenga, J-J., Jamain, S., Jones, I., Jones, L. A., Juréus, A., Kahn, R. S., Kammerer-Ciernioch, J., Kirov, G., Kittel-Schneider, S., Kloiber, S., Knott, S. V., Kogevinas, M., Landén, M., Leber, M., Leboyer, M., Li, Q. S., Lissowska, J., Lucae, S., Martin, N. G., Mayoral-Cleries, F., McElroy, S. L., McIntosh, A. M., McKay, J. D., McQuillin, A., Medland, S. E., Middeldorp, C. M., Milaneschi, Y., Mitchell, P. B., Montgomery, G. W., Morken, G., Mors, O., Mühleisen, T. W., Müller-Myhsok, B., Myers, R. M., Nievergelt, C. M., Nurnberger, J. I., O'Donovan, M. C., Loohuis, L. M. O., Ophoff, R., Oruc, L., Owen, M. J., Paciga, S. A., Penninx, B. W. J. H., Perry, A., Pfennig, A., Potash, J. B., Preisig, M., Reif, A., Rivas, F., Rouleau, G. A., Schofield, P. R., Schulze, T. G., Schwarz, M., Scott, L., Sinnamon, G. C. B., Stahl, E. A., Strauss, J., Turecki, G., Van der Auwera, S., Vedder, H., Vincent, J. B., Willemsen, G., Witt, C. C., Wray, N. R., Xi, H. S., Tadic, A., Dahmen, N., Schott, B. H., Cichon, S., Nöthen, M. M., Ripke, S., Mobascher, A., Rujescu, D., Lieb, K., Roepke, S., Schmahl, C., Bohus, M., Rietschel, M., Knight, J. & Bipolar Disorders Working Group of the Psychiatric Genomics Consortium 20/06/2017 In : Translational Psychiatry. 7, 6, 9 p., e1155

    Research output: Contribution to journalJournal article

  21. Published

    Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

    Knight, J., Project MinE GWAS Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium 21/03/2017 In : Nature Communications. 8, 12 p., 14774

    Research output: Contribution to journalJournal article

  22. Published

    Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

    Warren, H. R. , Evangelou, E. , Cabrera, C. P. , Gao, H. , Ren, M. , Mifsud, B. , Ntalla, I. , Surendran, P. , Liu, C. , Cook, J. P. , Kraja, A. T. , Drenos, F. , Loh, M. , Verweij, N. , Marten, J. , Karaman, I. , Lepe, M. P. S. , O'Reilly, P. F. , Knight, J. , Snieder, H. & 44 others Kato, N., He, J., Tai, E. S., Said, M. A., Porteous, D., Alver, M., Poulter, N., Farrall, M., Gansevoort, R. T., Padmanabhan, S., Mägi, R., Stanton, A., Connell, J., Bakker, S. J. L., Metspalu, A., Shields, D. C., Thom, S., Brown, M., Sever, P., Esko, T., Hayward, C., van der Harst, P., Saleheen, D., Chowdhury, R., Chambers, J. C., Chasman, D. I., Chakravarti, A., Newton-Cheh, C., Lindgren, C. M., Levy, D., Kooner, J. S., Keavney, B., Tomaszewski, M., Samani, N. J., Howson, J. M. M., Tobin, M. D., Munroe, P. B., Ehret, G. B., Wain, L. V., Barnes, M. R., Tzoulaki, I., Caulfield, M. J., Elliott, P. & International Consortium of Blood Pressure (ICBP) 1000G Analyses 20/02/2017 In : Nature Genetics. 49, p. 403-415 13 p.

    Research output: Contribution to journalJournal article

  23. Published

    Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

    CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium 01/2017 In : Nature Genetics. 49, p. 27-35 9 p.

    Research output: Contribution to journalJournal article

  24. 2016
  25. Published

    Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s diseases

    Gagliano, S. A., Pouget, J. G., Hardy, J., Knight, J., Barnes, M. R., Ryten, M. & Weale, M. 12/2016 In : Annals of Clinical and Translational Neurology. 3, 12, p. 924-933 10 p.

    Research output: Contribution to journalJournal article

  26. Published

    No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study

    Johnson, E. C. , Bjelland, D. W. , Howrigan, D. P. , Abdellaoui, A. , Breen, G. , Borglum, A. , Cichon, S. , Degenhardt, F. , Forstner, A. J. , Frank, J. , Genovese, G. , Heilmann-Heimbach, S. , Herms, S. , Hoffman, P. , Maier, W. , Mattheisen, M. , Morris, D. , Mowry, B. , Müller-Mhysok, B. , Neale, B. & 15 others Nenadic, I., Nöthen, M. M., O'Dushlaine, C., Rietschel, M., Ruderfer, D. M., Rujescu, D., Schulze, T. G., Simonson, M. A., Stahl, E., Strohmaier, J., Witt, S. H., Sullivan, P. F., Keller, M. C., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium 28/10/2016 In : PLOS Genetics. 12, 10, 20 p., e1006343

    Research output: Contribution to journalJournal article

  27. Published

    Genome-wide association studies suggest limited immune gene enrichment in schizophrenia compared to 5 autoimmune diseases

    Pouget, J. G., Gonçalves, V. F., Spain, S. L., Finucane, H. K., Raychaudhuri, S., Kennedy, J. L., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium 09/2016 In : Schizophrenia Bulletin. 42, 5, p. 1176-1184 9 p.

    Research output: Contribution to journalJournal article

  28. Published

    Genetic Markers of Human Evolution Are Enriched in Schizophrenia

    Srinivasan, S., Bettella, F., Mattingsdal, M., Wang, Y., Witoelar, A., Schork, A. J., Thompson, W. K., Zuber, V., Winsvold, B. S., Zwart, J-A., Collier, D. A., Desikan, R. S., Melle, I., Werge, T., Dale, A. M., Djurovic, S., Andreassen, O. A., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium, The International Headache Genetics Consortium 15/08/2016 In : Biological Psychiatry. 80, 4, p. 284-92 9 p.

    Research output: Contribution to journalJournal article

  29. Published

    CEREBRAL PERFUSION AS AN IMAGING BIOMARKER OF PRESYMPTOMATIC GENETIC FRONTOTEMPORAL DEMENTIA: PRELIMINARY RESULTS FROM THE GENETIC FRONTOTEMPORAL DEMENTIA INITIATIVE (GENFI)

    Mutsaerts, H. J. M. M. & Knight, J. 07/2016 In : Alzheimer's and Dementia. 12, 7 Suppl., p. P409-P411 3 p.

    Research output: Contribution to journalMeeting abstract

  30. Published

    Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: a pharmacogenetic study

    Masellis, M., Collinson, S., Freeman, N., Tampakeras, M., Levy, J., Tchelet, A., Eyal, E., Berkovich, E., Eliaz, R. E., Abler, V., Grossman, I., Fitzer-Attas, C., Tiwari, A., Hayden, M. R., Kennedy, J. L., Lang, A. E., Knight, J. & ADAGIO investigators 07/2016 In : Brain. 139, 7, p. 2050-2062 13 p.

    Research output: Contribution to journalJournal article

  31. Published

    Identification of Gene Loci That Overlap Between Schizophrenia and Educational Attainment

    Le Hellard, S., Wang, Y., Witoelar, A., Zuber, V., Bettella, F., Hugdahl, K., Espeseth, T., Steen, V. M., Melle, I., Desikan, R., Schork, A. J., Thompson, W. K., Dale, A. M., Djurovic, S., Andreassen, O. A., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium 26/06/2016 In : Schizophrenia Bulletin. 43, 3, p. 654-664 11 p.

    Research output: Contribution to journalJournal article

  32. Published

    Investigating the causal relationship of C-reactive protein with 32 complex somatic and psychiatric outcomes: a large-scale cross-consortium Mendelian randomization study

    Prins, B. P. , Abbasi, A. , Wong, A. , Vaez, A. , Nolte, I. , Franceschini, N. , Stuart, P. E. , Guterriez Achury, J. , Mistry, V. , Bradfield, J. P. , Valdes, A. M. , Bras, J. , Shatunov, A. , Lu, C. , Han, B. , Raychaudhuri, S. , Bevan, S. , Mayes, M. D. , Tsoi, L. C. , Evangelou, E. & 28 others Nair, R. P., Grant, S. F. A., Polychronakos, C., Radstake, T. R. D., van Heel, D. A., Dunstan, M. L., Wood, N. W., Al-Chalabi, A., Dehghan, A., Hakonarson, H., Markus, H. S., Elder, J. T., Knight, J., Arking, D. E., Spector, T. D., Koeleman, B. P. C., van Duijn, C. M., Martin, J., Morris, A. P., Weersma, R. K., Wijmenga, C., Munroe, P. B., Perry, J. R. B., Pouget, J. G., Jamshidi, Y., Snieder, H., Alizadeh, B. Z. & PAGE Consortium 21/06/2016 In : PLoS Medicine. 13, 6, 29 p., e1001976

    Research output: Contribution to journalJournal article

  33. Published

    Allele-skewed DNA modification in the brain: relevance to a schizophrenia GWAS

    Gagliano, S. A., Ptak, C., Mak, D. Y. F., Shamsi, M., Oh, G., Knight, J., Boutros, P. C. & Petronis, A. 5/05/2016 In : American Journal of Human Genetics. 98, 5, p. 956-962 7 p.

    Research output: Contribution to journalJournal article

  34. Published

    Gene prioritization for imaging genetics studies using gene ontology and a stratified false discovery rate approach

    Patel, S., Park, M. T. M., Chakravarty, M. M., Knight, J. & Alzheimer's Disease Neuroimaging Initiative 7/04/2016 In : Frontiers in Neuroinformatics. 10, 13 p., 14

    Research output: Contribution to journalJournal article

  35. Published

    Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants

    Hauberg, M. E., Roussos, P., Grove, J., Børglum, A. D., Mattheisen, M., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium 04/2016 In : JAMA Psychiatry. 73, 4, p. 369-377 9 p.

    Research output: Contribution to journalJournal article

  36. Published

    Genetic association analysis of N-methyl-d-aspartate receptor subunit gene GRIN2B and clinical response to clozapine

    Taylor, D. L., Tiwari, A. K., Lieberman, J. A., Potkin, S. G., Meltzer, H. Y., Knight, J., Remington, G., Müller, D. J. & Kennedy, J. L. 03/2016 In : Human Psychopharmacology: Clinical and Experimental. 31, 2, p. 121-134 14 p.

    Research output: Contribution to journalJournal article

  37. Published

    Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

    Franke, B. , Stein, J. L. , Ripke, S. , Anttila, V. , Hibar, D. P. , van Hulzen, K. J. E. , Arias-Vasquez, A. , Smoller, J. W. , Nichols, T. E. , Neale, M. C. , McIntosh, A. M. , Lee, P. , McMahon, F. J. , Meyer-Lindenberg, A. , Mattheisen, M. , Andreassen, O. A. , Gruber, O. , Sachdev, P. S. , Roiz-Santiañez, R. , Saykin, A. J. & 16 others Ehrlich, S., Mather, K. A., Turner, J. A., Schwarz, E., Thalamuthu, A., Yao, Y., Ho, Y. Y. W., Martin, N. G., Wright, M. J., O'Donovan, M. C., Thompson, P. M., Neale, B. M., Medland, S. E., Sullivan, P. F., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium 03/2016 In : Nature Reviews Neuroscience. 19, 3, p. 420-431 12 p.

    Research output: Contribution to journalJournal article

  38. Published

    Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness

    Bigdeli, T. B. , Ripke, S. , Bacanu, S-A. , Lee, S. H. , Wray, N. R. , Gejman, P. V. , Rietschel, M. , Cichon, S. , St Clair, D. , Corvin, A. , Kirov, G. , McQuillin, A. , Gurling, H. , Rujescu, D. , Andreassen, O. A. , Werge, T. , Blackwood, D. H. R. , Pato, C. N. , Pato, M. T. , Malhotra, A. K. & 5 others O'Donovan, M. C., Kendler, K. S., Fanous, A. H., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium 03/2016 In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 171B, 2, p. 276-89 14 p.

    Research output: Contribution to journalJournal article

  39. Published

    Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

    Holland, D., Wang, Y., Thompson, W. K., Schork, A., Chen, C-H., Lo, M-T., Witoelar, A., Werge, T., O'Donovan, M., Andreassen, O. A., Dale, A. M., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium 16/02/2016 In : Frontiers in Genetics. 7, 13 p., 15

    Research output: Contribution to journalJournal article

  40. Published

    Schizophrenia risk from complex variation of complement component 4

    Sekar, A., Bialas, A. R., de Rivera, H., Davis, A., Hammond, T. R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V., Genovese, G., Rose, S. A., Handsaker, R. E., Daly, M. J., Carroll, M. C., Stevens, B., McCarroll, S. A., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium 11/02/2016 In : Nature. 530, 7589, p. 177-183 7 p.

    Research output: Contribution to journalJournal article

  41. Published

    IBD genetic risk profile in healthy first-degree relatives of Crohn's disease patients

    Kevans, D., Silverberg, M. S., Borowski, K., Griffiths, A., Xu, W., Onay, V., Paterson, A. D., Knight, J., Croitoru, K. & GEM Project 02/2016 In : Journal of Crohn's and Colitis. 10, 2, p. 209-215 7 p.

    Research output: Contribution to journalJournal article

  42. Published

    Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS

    Wang, Y. , Thompson, W. K. , Schork, A. J. , Holland, D. , Chen, C-H. , Bettella, F. , Desikan, R. S. , Li, W. , Witoelar, A. , Zuber, V. , Devor, A. , Nöthen, M. M. , Rietschel, M. , Chen, Q. , Werge, T. , Cichon, S. , Weinberger, D. R. , Djurovic, S. , O'Donovan, M. , Visscher, P. M. & 4 others Andreassen, O. A., Dale, A. M., Knight, J. & Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium 01/2016 In : PLOS Genetics. 12, 1, 22 p., e1005803

    Research output: Contribution to journalJournal article

  43. 2015
  44. Published

    Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis

    Loh, P-R., Bhatia, G., Gusev, A., Finucane, H. K., Bulik-Sullivan, B. K., Pollack, S. J., de Candia, T. R., Lee, S. H., Wray, N. R., Kendler, K. S., O'Donovan, M. C., Neale, B. M., Patterson, N., Price, A. L., Knight, J. & Schizophrenia Working Group of Psychiatric Genomics Consortium 12/2015 In : Nature Genetics. 47, 12, p. 1385-1392 8 p.

    Research output: Contribution to journalJournal article

  45. Published

    Modeling linkage disequilibrium increases accuracy of polygenic risk scores

    Vilhjálmsson, B. J. , Yang, J. , Finucane, H. K. , Gusev, A. , Lindström, S. , Ripke, S. , Genovese, G. , Loh, P-R. , Bhatia, G. , Do, R. , Hayeck, T. , Won, H-H. , Kathiresan, S. , Pato, M. , Pato, C. , Tamimi, R. , Stahl, E. , Zaitlen, N. , Pasaniuc, B. , Belbin, G. & 16 others Kenny, E. E., Schierup, M. H., De Jager, P., Patsopoulos, N. A., McCarroll, S., Daly, M., Purcell, S., Chasman, D., Neale, B., Goddard, M., Visscher, P. M., Kraft, P., Patterson, N., Price, A. L., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study 1/10/2015 In : American Journal of Human Genetics. 97, 4, p. 576-592 17 p.

    Research output: Contribution to journalJournal article

  46. Published

    Predictors of outcome in ulcerative colitis

    Waterman, M., Knight, J., Dinani, A., Xu, W., Stempak, J. M., Croitoru, K., Nguyen, G. C., Cohen, Z., McLeod, R. S., Greenberg, G. R., Steinhart, A. H. & Silverberg, M. S. 09/2015 In : Inflammatory Bowel Diseases. 21, 9, p. 2097-2105 9 p.

    Research output: Contribution to journalJournal article

  47. Published

    Smoking gun or circumstantial evidence?: comparison of statistical learning methods using functional annotations for prioritizing risk variants

    Gagliano, S. A., Ravji, R., Barnes, M. R., Weale, M. E. & Knight, J. 24/08/2015 In : Scientific Reports. 5, 11 p., 13373

    Research output: Contribution to journalJournal article

  48. Published

    Addiction-related genes in gambling disorders: new insights from parallel human and pre-clinical models

    Lobo, D. S. S., Aleksandrova, L., Knight, J., Casey, D. M., el-Guebaly, N., Nobrega, J. N. & Kennedy, J. L. 08/2015 In : Molecular Psychiatry. 20, 8, p. 1002-1010 9 p.

    Research output: Contribution to journalJournal article

  49. Published

    A genome-wide association study of suicide severity scores in bipolar disorder

    Zai, C. C., Gonçalves, V. F., Tiwari, A. K., Gagliano, S. A., Hosang, G., de Luca, V., Shaikh, S. A., King, N., Chen, Q., Xu, W., Strauss, J., Breen, G., Lewis, C. M., Farmer, A. E., McGuffin, P., Knight, J., Vincent, J. B. & Kennedy, J. L. 06/2015 In : Journal of Psychiatric Research. 65, p. 23-29 7 p.

    Research output: Contribution to journalJournal article

  50. Published

    Assessing models for genetic prediction of complex traits: a comparison of visualization and quantitative methods

    Gagliano, S. A., Paterson, A. D., Weale, M. E. & Knight, J. 22/05/2015 In : BMC Genomics. 16, 11 p., 405

    Research output: Contribution to journalJournal article

  51. Published

    Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

    Tsoi, L. C. , Spain, S. L. , Ellinghaus, E. , Stuart, P. E. , Capon, F. , Knight, J. , Tejasvi, T. , Kang, H. M. , Allen, M. H. , Lambert, S. , Stoll, S. W. , Weidinger, S. , Gudjonsson, J. E. , Koks, S. , Kingo, K. , Esko, T. , Das, S. , Metspalu, A. , Weichenthal, M. , Enerback, C. & 13 others Krueger, G. G., Voorhees, J. J., Chandran, V., Rosen, C. F., Rahman, P., Gladman, D. D., Reis, A., Nair, R. P., Franke, A., Barker, J. N. W. N., Abecasis, G. R., Trembath, R. C. & Elder, J. T. 5/05/2015 In : Nature Communications. 6, 8 p., 7001

    Research output: Contribution to journalJournal article

  52. Published

    LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

    Bulik-Sullivan, B. K., Loh, P-R., Finucane, H. K., Ripke, S., Yang, J., Patterson, N., Daly, M. J., Price, A. L., Neale, B. M., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium 03/2015 In : Nature Genetics. 47, 3, p. 291-295 5 p.

    Research output: Contribution to journalJournal article

  53. Published

    Pooled sequencing of 531 genes in inflammatory bowel disease identifies an associated rare variant in BTNL2 and implicates other immune related genes

    Prescott, N. J. , Lehne, B. , Stone, K. , Lee, J. C. , Taylor, K. , Knight, J. , Papouli, E. , Mirza, M. M. , Simpson, M. A. , Spain, S. L. , Lu, G. , Fraternali, F. , Bumpstead, S. J. , Gray, E. , Amar, A. , Bye, H. , Green, P. , Chung-Faye, G. , Hayee, B. H. , Pollok, R. & 10 others Satsangi, J., Parkes, M., Barrett, J. C., Mansfield, J. C., Sanderson, J., Lewis, C. M., Weale, M. E., Schlitt, T., Mathew, C. G. & UK IBD Genetics Consortium 11/02/2015 In : PLOS Genetics. 11, 2, e1004955

    Research output: Contribution to journalJournal article

  54. Published

    CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers: findings from two independent populations

    Wassenaar, C. A., Ye, Y., Cai, Q., Aldrich, M. C., Knight, J., Spitz, M. R., Wu, X., Blot, W. J. & Tyndale, R. F. 01/2015 In : Carcinogenesis. 36, 1, p. 99-103 5 p.

    Research output: Contribution to journalJournal article

  55. Published

    Investigation of TSPO variants in schizophrenia and antipsychotic treatment outcomes

    Pouget, J. G. , Gonçalves, V. F. , Nurmi, E. L. , Laughlin, C. P. , Mallya, K. S. , McCracken, J. T. , Aman, M. G. , McDougle, C. J. , Scahill, L. , Misener, V. L. , Tiwari, A. K. , Zai, C. C. , Brandl, E. J. , Felsky, D. , Leung, A. Q. , Lieberman, J. A. , Meltzer, H. Y. , Potkin, S. G. , Niedling, C. , Steimer, W. & 4 others Leucht, S., Knight, J., Müller, D. J. & Kennedy, J. L. 01/2015 In : Pharmacogenomics. 16, 1, p. 5-22 18 p.

    Research output: Contribution to journalJournal article

  56. 2014
  57. Published

    Complex host genetics influence the microbiome in inflammatory bowel disease

    Knights, D., Silverberg, M. S., Weersma, R. K., Gevers, D., Dijkstra, G., Huang, H., Tyler, A. D., van Sommeren, S., Imhann, F., Stempak, J. M., Huang, H., Vangay, P., Al-Ghalith, G. A., Russell, C., Sauk, J., Knight, J., Daly, M. J., Huttenhower, C. & Xavier, R. J. 2/12/2014 In : Genome Biology. 6, 12, 11 p., 107

    Research output: Contribution to journalJournal article

  58. Published

    Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

    Gusev, A. , Lee, S. H. , Trynka, G. , Finucane, H. , Vilhjálmsson, B. J. , Xu, H. , Zang, C. , Ripke, S. , Bulik-Sullivan, B. , Stahl, E. , Kähler, A. K. , Hultman, C. M. , Purcell, S. M. , McCarroll, S. A. , Daly, M. , Pasaniuc, B. , Sullivan, P. F. , Neale, B. M. , Wray, N. R. , Raychaudhuri, S. & 3 others Price, A. L., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium 6/11/2014 In : American Journal of Human Genetics. 95, 5, p. 535-552 18 p.

    Research output: Contribution to journalJournal article

  59. Published

    The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa

    Yilmaz, Z. , Kaplan, A. S. , Tiwari, A. K. , Levitan, R. D. , Piran, S. , Bergen, A. W. , Kaye, W. H. , Hakonarson, H. , Wang, K. , Berrettini, W. H. , Brandt, H. A. , Bulik, C. M. , Crawford, S. , Crow, S. , Fichter, M. M. , Halmi, K. A. , Johnson, C. L. , Keel, P. K. , Klump, K. L. , Magistretti, P. & 7 others Mitchell, J., Strober, M., Thornton, L. M., Treasure, J., Woodside, D. B., Knight, J. & Kennedy, J. L. 08/2014 In : Journal of Psychiatric Research. 55, p. 77-86 10 p.

    Research output: Contribution to journalJournal article

  60. Published

    Biological insights from 108 schizophrenia-associated genetic loci

    Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium 24/07/2014 In : Nature. 511, 7510, p. 421-427 7 p.

    Research output: Contribution to journalJournal article

  61. Published

    Protein kinase cAMP-dependent regulatory type II beta (PRKAR2B) gene variants in antipsychotic-induced weight gain

    Gagliano, S. A., Tiwari, A. K., Freeman, N., Lieberman, J. A., Meltzer, H. Y., Kennedy, J. L., Knight, J. & Müller, D. J. 07/2014 In : Human Psychopharmacology: Clinical and Experimental. 29, 4, p. 330-335 6 p.

    Research output: Contribution to journalJournal article

  62. Published

    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris

    Navarini, A. A. , Simpson, M. A. , Weale, M. , Knight, J. , Carlavan, I. , Reiniche, P. , Burden, D. A. , Layton, A. , Bataille, V. , Allen, M. , Pleass, R. , Pink, A. , Creamer, D. , English, J. , Munn, S. , Walton, S. , Willis, C. , Déret, S. , Voegel, J. J. , Spector, T. & 4 others Smith, C. H., Trembath, R. C., Barker, J. N. W. N. & Acne Genetic Study Group 13/06/2014 In : Nature Communications. 5, 6 p., 4020

    Research output: Contribution to journalJournal article

  63. Published

    A Bayesian method to incorporate hundreds of functional characteristics with association evidence to improve variant prioritization

    Gagliano, S. A., Barnes, M. R., Weale, M. E. & Knight, J. 20/05/2014 In : PLoS ONE. 9, 5, 14 p., e98122

    Research output: Contribution to journalJournal article

  64. Published

    Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1

    Xu, W., Cohen-Woods, S., Chen, Q., Noor, A., Knight, J., Hosang, G., Parikh, S. V., De Luca, V., Tozzi, F., Muglia, P., Forte, J., McQuillin, A., Hu, P., Gurling, H. M. D., Kennedy, J. L., McGuffin, P., Farmer, A., Strauss, J. & Vincent, J. B. 4/01/2014 In : Journal of Medical Genetics. 15, 13 p., 2

    Research output: Contribution to journalJournal article

  65. 2012
  66. Published

    Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis

    Knight, J., Spain, S. L., Capon, F., Hayday, A., Nestle, F. O., Clop, A., Barker, J. N. W. N., Weale, M. E., Trembath, R. C. & Wellcome Trust Case Control Consortium 1/12/2012 In : Human Molecular Genetics. 21, 23, p. 5185-5192 8 p.

    Research output: Contribution to journalJournal article

  67. Published

    Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

    Tsoi, L. C. , Spain, S. L. , Knight, J. , Ellinghaus, E. , Stuart, P. E. , Capon, F. , Ding, J. , Li, Y. , Tejasvi, T. , Gudjonsson, J. E. , Kang, H. M. , Allen, M. H. , McManus, R. , Novelli, G. , Samuelsson, L. , Schalkwijk, J. , Ståhle, M. , Burden, A. D. , Smith, C. H. , Cork, M. J. & 46 others Estivill, X., Bowcock, A. M., Krueger, G. G., Weger, W., Worthington, J., Tazi-Ahnini, R., Nestle, F. O., Hayday, A., Hoffmann, P., Winkelmann, J., Wijmenga, C., Langford, C., Edkins, S., Andrews, R., Blackburn, H., Strange, A., Band, G., Pearson, R. D., Vukcevic, D., Spencer, C. C. A., Deloukas, P., Mrowietz, U., Schreiber, S., Weidinger, S., Koks, S., Kingo, K., Esko, T., Metspalu, A., Lim, H. W., Voorhees, J. J., Weichenthal, M., Wichmann, H. E., Chandran, V., Rosen, C. F., Rahman, P., Gladman, D. D., Griffiths, C. E. M., Reis, A., Kere, J., Nair, R. P., Franke, A., Barker, J. N. W. N., Abecasis, G. R., Elder, J. T., Trembath, R. C. & Collaborative Association Study of Psoriasis (CASP) 12/2012 In : Nature Genetics. 44, 12, p. 1341-1348 8 p.

    Research output: Contribution to journalLetter

  68. Published

    Introduction to genetic association studies

    Lewis, C. M. & Knight, J. 03/2012 In : Cold Spring Harbor Protocols. 2012, 3, p. 297-306 10 p.

    Research output: Contribution to journalJournal article

  69. 2011
  70. Published

    Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis

    Onoufriadis, A., Simpson, M. A., Pink, A. E., Di Meglio, P., Smith, C. H., Pullabhatla, V., Knight, J., Spain, S. L., Nestle, F. O., Burden, A. D., Capon, F., Trembath, R. C. & Barker, J. N. W. N. 9/09/2011 In : American Journal of Human Genetics. 89, 3, p. 432-437 6 p.

    Research output: Contribution to journalJournal article

  71. Published

    A genome-wide significant linkage for severe depression on chromosome 3: the depression network study

    Breen, G. , Webb, B. T. , Butler, A. W. , van den Oord, E. J. C. G. , Tozzi, F. , Craddock, N. , Gill, M. , Korszun, A. , Maier, W. , Middleton, L. , Mors, O. , Owen, M. J. , Cohen-Woods, S. , Perry, J. , Galwey, N. W. , Upmanyu, R. , Craig, I. , Lewis, C. M. , Ng, M. , Brewster, S. & 8 others Preisig, M., Rietschel, M., Jones, L., Knight, J., Rice, J., Muglia, P., Farmer, A. E. & McGuffin, P. 08/2011 In : American Journal of Psychiatry. 168, 8, p. 840-847 8 p.

    Research output: Contribution to journalJournal article

  72. Published

    Using functional annotation for the empirical determination of Bayes Factors for genome-wide association study analysis

    Knight, J., Barnes, M. R., Breen, G. & Weale, M. E. 27/04/2011 In : PLoS ONE. 6, 4, 8 p., e14808

    Research output: Contribution to journalJournal article

  73. Published

    Common variants in DGKK are strongly associated with risk of hypospadias

    van der Zanden, L. F. M., van Rooij, I. A. L. M., Feitz, W. F. J., Knight, J., Donders, A. R. T., Renkema, K. Y., Bongers, E. M. H. F., Vermeulen, S. H. H. M., Kiemeney, L. A. L. M., Veltman, J. A., Arias-Vásquez, A., Zhang, X., Markljung, E., Qiao, L., Baskin, L. S., Nordenskjöld, A., Roeleveld, N., Franke, B. & Knoers, N. V. A. M. 01/2011 In : Nature Genetics. 43, 1, p. 48-50 3 p.

    Research output: Contribution to journalLetter

  74. 2010
  75. Published

    A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

    Strange, A. , Capon, F. , Spencer, C. C. A. , Knight, J. , Weale, M. E. , Allen, M. H. , Barton, A. , Band, G. , Bellenguez, C. , Bergboer, J. G. M. , Blackwell, J. M. , Bramon, E. , Bumpstead, S. J. , Casas, J. P. , Cork, M. J. , Corvin, A. , Deloukas, P. , Dilthey, A. , Duncanson, A. , Edkins, S. & 65 others Estivill, X., Fitzgerald, O., Freeman, C., Giardina, E., Gray, E., Hofer, A., Hüffmeier, U., Hunt, S. E., Irvine, A. D., Jankowski, J., Kirby, B., Langford, C., Lascorz, J., Leman, J., Leslie, S., Mallbris, L., Markus, H. S., Mathew, C. G., McLean, W. H. I., McManus, R., Mössner, R., Moutsianas, L., Naluai, A. T., Nestle, F. O., Novelli, G., Onoufriadis, A., Palmer, C. N. A., Perricone, C., Pirinen, M., Plomin, R., Potter, S. C., Pujol, R. M., Rautanen, A., Riveira-Munoz, E., Ryan, A. W., Salmhofer, W., Samuelsson, L., Sawcer, S. J., Schalkwijk, J., Smith, C. H., Ståhle, M., Su, Z., Tazi-Ahnini, R., Traupe, H., Viswanathan, A. C., Warren, R. B., Weger, W., Wolk, K., Wood, N., Worthington, J., Young, H. S., Zeeuwen, P. L. J. M., Hayday, A., Burden, A. D., Griffiths, C. E. M., Kere, J., Reis, A., McVean, G., Evans, D. M., Brown, M. A., Barker, J. N., Peltonen, L., Donnelly, P., Trembath, R. C. & Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2 11/2010 In : Nature Genetics. 42, 11, p. 985-990 6 p.

    Research output: Contribution to journalLetter

  76. Published

    An investigation of candidate regions for association with bipolar disorder

    Knight, J., Rochberg, N. S., Saccone, S. F., Nurnberger, J. I., Rice, J. P. & NIMH Genetics Initiative Bipolar Disorder Consortium 5/10/2010 In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 153B, 7, p. 1292-1297 6 p.

    Research output: Contribution to journalJournal article

  77. Published

    The Bipolar Association Case-Control Study (BACCS) and meta-analysis: no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder

    Cohen-Woods, S. , Craig, I. , Gaysina, D. , Gray, J. , Gunasinghe, C. , Craddock, N. , Elkin, A. , Jones, L. , Kennedy, J. , King, N. , Korszun, A. , Knight, J. , Owen, M. , Parikh, S. , Strauss, J. , Sterne, A. , Tozzi, F. , Perry, J. , Muglia, P. , Vincent, J. & 2 others McGuffin, P. & Farmer, A. 5/10/2010 In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 153B, 7, p. 1298-1304 7 p.

    Research output: Contribution to journalJournal article

  78. Published

    Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders

    Beall, C. M. , Cavalleri, G. L. , Deng, L. , Elston, R. C. , Gao, Y. , Knight, J. , Li, C. , Li, J. C. , Liang, Y. , McCormack, M. , Montgomery, H. E. , Pan, H. , Robbins, P. A. , Shianna, K. V. , Tam, S. C. , Tsering, N. , Veeramah, K. R. , Wang, W. , Wangdui, P. , Weale, M. E. & 9 others Xu, Y., Xu, Z., Yang, L., Zaman, M. J., Zeng, C., Zhang, L., Zhang, X., Zhaxi, P. & Zheng, Y. T. 22/06/2010 In : Proceedings of the National Academy of Sciences. 107, 25, p. 11459-11464 6 p.

    Research output: Contribution to journalJournal article

  79. Published

    Software for generating liability distributions for pedigrees conditional on their observed disease states and covariates

    Campbell, D. D., Sham, P. C., Knight, J., Wickham, H. & Landau, S. 02/2010 In : Genetic Epidemiology. 34, 2, p. 159-170 12 p.

    Research output: Contribution to journalJournal article

  80. 2009
  81. Published

    Depression Case Control (DeCC) study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder

    Cohen-Woods, S., Gaysina, D., Craddock, N., Farmer, A., Gray, J., Gunasinghe, C., Hoda, F., Jones, L., Knight, J., Korszun, A., Owen, M. J., Sterne, A., Craig, I. W. & McGuffin, P. 15/04/2009 In : Human Molecular Genetics. 18, 8, p. 1504-1509 6 p.

    Research output: Contribution to journalJournal article

  82. Published

    A comparison of association statistics between pooled and individual genotypes

    Knight, J., Saccone, S. F., Zhang, Z., Ballinger, D. G. & Rice, J. P. 03/2009 In : Human Heredity. 67, 4, p. 219-225 7 p.

    Research output: Contribution to journalJournal article

  83. Published

    Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration

    Simpson, C. L. , Lemmens, R. , Miskiewicz, K. , Broom, W. J. , Hansen, V. K. , van Vught, P. W. J. , Landers, J. E. , Sapp, P. , Van Den Bosch, L. , Knight, J. , Neale, B. M. , Turner, M. R. , Veldink, J. H. , Ophoff, R. A. , Tripathi, V. B. , Beleza, A. , Shah, M. N. , Proitsi, P. , Van Hoecke, A. , Carmeliet, P. & 10 others Horvitz, H. R., Leigh, P. N., Shaw, C. E., van den Berg, L. H., Sham, P. C., Powell, J. F., Verstreken, P., Brown, R. H., Robberecht, W. & Al-Chalabi, A. 1/02/2009 In : Human Molecular Genetics. 18, 3, p. 472-481 10 p.

    Research output: Contribution to journalJournal article

  84. 2008
  85. Published

    DSM-IV combined type ADHD shows familial association with sibling trait scores: a sampling strategy for QTL linkage

    Chen, W. , Zhou, K. , Sham, P. , Franke, B. , Kuntsi, J. , Campbell, D. , Fleischman, K. , Knight, J. , Andreou, P. , Arnold, R. , Altink, M. , Boer, F. , Boholst, M. J. , Buschgens, C. , Butler, L. , Christiansen, H. , Fliers, E. , Howe-Forbes, R. , Gabriëls, I. , Heise, A. & 30 others Korn-Lubetzki, I., Marco, R., Medad, S., Minderaa, R., Müller, U. C., Mulligan, A., Psychogiou, L., Rommelse, N., Sethna, V., Uebel, H., McGuffin, P., Plomin, R., Banaschewski, T., Buitelaar, J., Ebstein, R., Eisenberg, J., Gill, M., Manor, I., Miranda, A., Mulas, F., Oades, R. D., Roeyers, H., Rothenberger, A., Sergeant, J., Sonuga-Barke, E., Steinhausen, H-C., Taylor, E., Thompson, M., Faraone, S. V. & Asherson, P. 5/12/2008 In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 147B, 8, p. 1450-1460 11 p.

    Research output: Contribution to journalJournal article

  86. Published

    A simple method for assessing the strength of evidence for association at the level of the whole gene

    Curtis, D., Vine, A. E. & Knight, J. 17/11/2008 In : Advances and Applications in Bioinformatics and Chemistry : AABC. 1, p. 115-120 6 p.

    Research output: Contribution to journalJournal article

  87. Published

    CLUMPHAP: a simple tool for performing haplotype-based association analysis

    Knight, J., Curtis, D. & Sham, P. C. 09/2008 In : Genetic Epidemiology. 32, 6, p. 539-545 7 p.

    Research output: Contribution to journalJournal article

  88. Published

    Investigation into the ability of SNP chipsets and microsatellites to detect association with a disease locus

    Curtis, D., Vine, A. E. & Knight, J. 07/2008 In : Annals of Human Genetics. 72, 4, p. 547-556 10 p.

    Research output: Contribution to journalJournal article

  89. Published

    Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins

    Rosa, A., Picchioni, M. M., Kalidindi, S., Loat, C. S., Knight, J., Toulopoulou, T., Vonk, R., van der Schot, A. C., Nolen, W., Kahn, R. S., McGuffin, P., Murray, R. M. & Craig, I. W. 5/06/2008 In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 147B, 4, p. 459-462 4 p.

    Research output: Contribution to journalJournal article

  90. Published

    Study of regions of extended homozygosity provides a powerful method to explore haplotype structure of human populations

    Curtis, D., Vine, A. E. & Knight, J. 03/2008 In : Annals of Human Genetics. 72, 2, p. 261-278 18 p.

    Research output: Contribution to journalJournal article

  91. Published

    Association of the serotonin transporter gene, neuroticism and smoking behaviours

    O'Gara, C., Knight, J., Stapleton, J., Luty, J., Neale, B., Nash, M., Heuzo-Diaz, P., Hoda, F., Cohen, S., Sutherland, G., Collier, D., Sham, P., Ball, D., McGuffin, P. & Craig, I. 2008 In : Journal of Human Genetics . 53, 3, p. 239-246 8 p.

    Research output: Contribution to journalJournal article

  92. 2007
  93. Published

    Dopamine genes and pathological gambling in discordant sib-pairs

    da Silva Lobo, D. S., Vallada, H. P., Knight, J., Martins, S. S., Tavares, H., Gentil, V. & Kennedy, J. L. 12/2007 In : Journal of Gambling Studies. 23, 4, p. 421-433 13 p.

    Research output: Contribution to journalJournal article

  94. Published

    Application of multi-locus analytical methods to identify interacting loci in case-control studies

    Vermeulen, S. H. H. M., Den Heijer, M., Sham, P. C. & Knight, J. 09/2007 In : Annals of Human Genetics. 71, 5, p. 689-700 12 p.

    Research output: Contribution to journalJournal article

  95. Published

    Age at onset in sod1-mediated amyotrophic lateral sclerosis shows familiality

    Fogh, I., Rijsdijk, F., Andersen, P. M., Sham, P. C., Knight, J., Neale, B., McKenna-Yasek, D., Silani, V., Brown, R. H., Powell, J. F. & Al-Chalabi, A. 08/2007 In : Neurogenetics. 8, 3, p. 235-236 2 p.

    Research output: Contribution to journalLetter

  96. Published

    A pragmatic suggestion for dealing with results for candidate genes obtained from genome wide association studies

    Curtis, D., Vine, A. E. & Knight, J. 10/05/2007 In : Genetics. 8, 6 p., 20

    Research output: Contribution to journalJournal article

  97. Published

    Homing in on depression genes

    McGuffin, P., Cohen, S. & Knight, J. 02/2007 In : American Journal of Psychiatry. 164, 2, p. 195-197 3 p.

    Research output: Contribution to journalEditorial

  98. Published

    Regional multi-locus association models

    Knight, J., Sham, P., Shaun, P. & Neale, B. 2007 Statistical genetics: gene mapping through linkage and association. Neale, B., Ferreira, M., Medland, S. & Posthuma, D. (eds.). London: Taylor and Francis

    Research output: Contribution in Book/Report/ProceedingsChapter

  99. 2006
  100. Published

    Investigation of the ability of haplotype association and logistic regression to identify associated susceptibility loci

    North, B. V., Sham, P. C., Knight, J., Martin, E. R. & Curtis, D. 11/2006 In : Annals of Human Genetics. 70, 6, p. 893-906 14 p.

    Research output: Contribution to journalJournal article

  101. Published

    The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes

    Brookes, K. , Xu, X. , Chen, W. , Zhou, K. , Neale, B. , Lowe, N. , Anney, R. , Franke, B. , Gill, M. , Ebstein, R. , Buitelaar, J. , Sham, P. , Campbell, D. , Knight, J. , Andreou, P. , Altink, M. , Arnold, R. , Boer, F. , Buschgens, C. , Butler, L. & 42 others Christiansen, H., Feldman, L., Fleischman, K., Fliers, E., Howe-Forbes, R., Goldfarb, A., Heise, A., Gabriëls, I., Korn-Lubetzki, I., Johansson, L., Marco, R., Medad, S., Minderaa, R., Mulas, F., Müller, U., Mulligan, A., Rabin, K., Rommelse, N., Sethna, V., Sorohan, J., Uebel, H., Psychogiou, L., Weeks, A., Barrett, R., Craig, I., Banaschewski, T., Sonuga-Barke, E., Eisenberg, J., Kuntsi, J., Manor, I., McGuffin, P., Miranda, A., Oades, R. D., Plomin, R., Roeyers, H., Rothenberger, A., Sergeant, J., Steinhausen, H-C., Taylor, E., Thompson, M., Faraone, S. V. & Asherson, P. 10/2006 In : Molecular Psychiatry. 11, 10, p. 934-953 20 p.

    Research output: Contribution to journalJournal article

  102. Published

    Design and analysis of association studies using pooled DNA from large twin samples

    Knight, J. & Sham, P. 09/2006 In : Behavior Genetics. 36, 5, p. 665-677 13 p.

    Research output: Contribution to journalJournal article

  103. Published

    NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis: a case-control association study

    Nibali, L., Parkar, M., Brett, P., Knight, J., Tonetti, M. S. & Griffiths, G. S. 08/2006 In : Journal of Clinical Periodontology. 33, 8, p. 529-539 11 p.

    Research output: Contribution to journalJournal article

  104. Published

    Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease

    Hamilton, G., Samedi, F., Knight, J., Archer, N., Foy, C., Walter, S., Turic, D., Jehu, L., Moore, P., Hollingworth, P., O'Donovan, M. C., Williams, J., Owen, M. J., Lovestone, S. & Powell, J. F. 19/06/2006 In : Neuroscience Letters. 401, 1-2, p. 77-80 4 p.

    Research output: Contribution to journalJournal article

  105. Published

    Program report: GENECOUNTING support programs

    Curtis, D., Knight, J. & Sham, P. C. 03/2006 In : Annals of Human Genetics. 70, Pt 2, p. 277-279 3 p.

    Research output: Contribution to journalJournal article

  106. Published

    A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy

    Brookes, K-J., Mill, J., Guindalini, C., Curran, S., Xu, X., Knight, J., Chen, C-K., Huang, Y-S., Sethna, V., Taylor, E., Chen, W., Breen, G. & Asherson, P. 01/2006 In : Archives of General Psychiatry. 63, 1, p. 74-81 8 p.

    Research output: Contribution to journalJournal article

  107. 2005
  108. Published

    Whole genome linkage scan of recurrent depressive disorder from the depression network study

    McGuffin, P., Knight, J., Breen, G., Brewster, S., Boyd, P. R., Craddock, N., Gill, M., Korszun, A., Maier, W., Middleton, L., Mors, O., Owen, M. J., Perry, J., Preisig, M., Reich, T., Rice, J., Rietschel, M., Jones, L., Sham, P. & Farmer, A. E. 15/11/2005 In : Human Molecular Genetics. 14, 22, p. 3337-3345 9 p.

    Research output: Contribution to journalJournal article

  109. Published

    DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters

    Brookes, K. J., Knight, J., Xu, X. & Asherson, P. 5/11/2005 In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 139B, 1, p. 33-37 5 p.

    Research output: Contribution to journalJournal article

  110. Published

    A new method of linkage analysis using LOD scores for quantitative traits supports linkage of monoamine oxidase activity to D17S250 in the Collaborative Study on the Genetics of Alcoholism pedigrees

    Curtis, D., Knight, J. & Sham, P. C. 09/2005 In : Psychiatric Genetics. 15, 3, p. 181-187 7 p.

    Research output: Contribution to journalJournal article

  111. Published

    SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children

    Butcher, L. M., Meaburn, E., Knight, J., Sham, P. C., Schalkwyk, L. C., Craig, I. W. & Plomin, R. 15/05/2005 In : Human Molecular Genetics. 14, 10, p. 1315-1325 11 p.

    Research output: Contribution to journalJournal article

  112. Published

    DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association

    Xu, X., Knight, J., Brookes, K., Mill, J., Sham, P., Craig, I., Taylor, E. & Asherson, P. 5/04/2005 In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 134B, 1, p. 115-118 4 p.

    Research output: Contribution to journalJournal article

  113. Published

    Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B

    Mill, J., Xu, X., Ronald, A., Curran, S., Price, T., Knight, J., Craig, I., Sham, P., Plomin, R. & Asherson, P. 5/02/2005 In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 133B, 1, p. 68-73 6 p.

    Research output: Contribution to journalJournal article

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