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Dr Leonie Unterholzner

Research Fellow/Lecturer

  1. 2019
  2. Published

    cGAS-independent STING activation in response to DNA damage

    Unterholzner, L. & Dunphy, G., 19/04/2019, In : Molecular & Cellular Oncology. 6, 4, 3 p., e1558682 .

    Research output: Contribution to journalJournal article

  3. Published

    Beyond sensing DNA: A role for cGAS in the detection of extracellular cyclic di-nucleotides

    Unterholzner, L., 1/04/2019, In : EMBO Reports. 20, 4, e47970.

    Research output: Contribution to journalJournal article

  4. Published

    Camouflage and interception: How pathogens evade detection by intracellular nucleic acid sensors

    Unterholzner, L. & Almine, J. F., 03/2019, In : Immunology. 156, 3, p. 217-227 11 p.

    Research output: Contribution to journalJournal article

  5. 2018
  6. Published

    Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-κB signalling after nuclear DNA damage

    Dunphy, G., Flannery, S., Almine, J., Connolly, D., Paulus, C., Jønsson, K., Jakobsen, M., Nevels, M., Bowie, A. & Unterholzner, L., 6/09/2018, In : Molecular Cell. 71, 5, p. 745-760 16 p.

    Research output: Contribution to journalJournal article

  7. 2017
  8. Published

    IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

    Almine, J. F., O'Hare, C. A. J., Dunphy, G., Haga, I. R., Naik, R. J., Atrih, A., Connolly, D. J., Taylor, J., Kelsall, I. R., Bowie, A. G., Beard, P. M. & Unterholzner, L., 13/02/2017, In : Nature Communications. 8, 14392.

    Research output: Contribution to journalJournal article

  9. 2013
  10. Published

    The interferon response to intracellular DNA: why so many receptors?

    Unterholzner, L., 11/2013, In : Immunobiology. 218, 11, p. 1312-1321 10 p.

    Research output: Contribution to journalJournal article

  11. Published

    Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

    Horan, K. A., Hansen, K., Jakobsen, M. R., Holm, C. K., Søby, S., Unterholzner, L., Thompson, M., West, J. A., Iversen, M. B., Rasmussen, S. B., Ellermann-Eriksen, S., Kurt-Jones, E., Landolfo, S., Damania, B., Melchjorsen, J., Bowie, A. G., Fitzgerald, K. A. & Paludan, S. R., 1/03/2013, In : Journal of Immunology. 190, 5, p. 2311-2319 9 p.

    Research output: Contribution to journalJournal article

  12. Published

    Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence

    Mansur, D. S., Maluquer de Motes, C., Unterholzner, L., Sumner, R. P., Ferguson, B. J., Ren, H., Strnadova, P., Bowie, A. G. & Smith, G. L., 02/2013, In : PLoS Pathogens. 9, 2, e1003183.

    Research output: Contribution to journalJournal article

  13. 2012
  14. Published

    Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor

    Jin, T., Perry, A., Jiang, J., Smith, P., Curry, J. A., Unterholzner, L., Jiang, Z., Horvath, G., Rathinam, V. A., Johnstone, R. W., Hornung, V., Latz, E., Bowie, A. G., Fitzgerald, K. A. & Xiao, T. S., 20/04/2012, In : Immunity. 36, 4, p. 561-571 11 p.

    Research output: Contribution to journalJournal article

  15. 2011
  16. Published

    Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7

    Unterholzner, L., Sumner, R. P., Baran, M., Ren, H., Mansur, D. S., Bourke, N. M., Randow, F., Smith, G. L. & Bowie, A. G., 09/2011, In : PLoS Pathogens. 7, 9, e1002247.

    Research output: Contribution to journalJournal article

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