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Dr Lorna Ashton

Senior Lecturer

  1. 2020
  2. Published

    Raman Spectroscopy with 2D Perturbation Correlation Moving Windows for the Characterization of Heparin–Amyloid Interactions

    Townsend, D., Middleton, D. & Ashton, L., 31/10/2020, In: Analytical Chemistry. 92, 20, p. 13822–13828 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Marine-inspired enzymatic mineralization of dairy-derived whey protein isolate (WPI) hydrogels for bone tissue regeneration

    Norris, K., Kocot, M., Tryba, A-M., Chai, F., Talari, A., Ashton, L., Parakhonskiy, B., Samal, S. K., Blanchemain, N., Pamula, E. & Douglas, T., 2/06/2020, In: Marine Drugs . 18, 6, 13 p., 294.

    Research output: Contribution to journalJournal articlepeer-review

  4. 2019
  5. Published

    Determination of Phosphorylation and Deprotonation Induced Higher Order Structural Transitions in αs‑Caseins

    Ettah, I. & Ashton, L., 1/11/2019, In: Analytical Chemistry. 91, 21, p. 13940-13946 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    Single-cell Raman microscopy of microengineered cell scaffolds

    Baldock, S. J., Talari, A. C. S., Smith, R., Wright, K. L. & Ashton, L., 30/03/2019, In: Journal of Raman Spectroscopy. 50, 3, p. 371-379 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. 2018
  8. Published

    Engaging with Raman spectroscopy to investigate antibody aggregation

    Ettah, I. & Ashton, L., 7/07/2018, In: Antibodies. 12 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  9. 2017
  10. Published

    Deep convolutional neural networks for Raman spectrum recognition: a unified solution

    Liu, J., Osadchy, M., Ashton, L., Foster, M., Solomon, C. J. & Gibson, S. J., 7/11/2017, In: Analyst. 142, 21, 8 p., 4067.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Detection of glycosylation and iron-binding protein modifications using Raman spectroscopy

    Ashton, L., Brewster, V., Correa, E. & Goodacre, R., 7/03/2017, In: Analyst. 142, 5, p. 808-814 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. 2016
  13. Published

    Two-dimensional codistribution spectroscopy applied to UVRR and ROA investigations of biomolecular transitions

    Ramer, G. & Ashton, L., 15/11/2016, In: Journal of Molecular Structure. 1124, p. 173-179 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Raman spectroscopy: an evolving technique for live cell studies

    Smith, R., Wright, K. L. & Ashton, L., 21/06/2016, In: Analyst. 2016, 12, p. 3590-3600 11 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  15. Published

    Using Raman spectroscopy to characterize biological materials

    Butler, H. J., Ashton, L., Bird, B., Cinque, G., Curtis, K., Dorney, J., Esmonde-White, K., Fullwood, N. J., Gardner, B., Martin-Hirsch, P. L., Walsh, M. J., McAinsh, M. R., Stone, N. & Martin, F. L., 04/2016, In: Nature Protocols. 11, 4, p. 664-687 24 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Detection of protein glycosylation using tip enhanced Raman scattering

    Cowcher, D., Deckert-Gaudig, T., Brewster, V., Ashton, L., Deckert, V. & Goodacre, R., 16/02/2016, In: Analytical Chemistry. 88, 4, p. 2105-2112 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. 2015
  18. Published

    Aseptic Raman spectroscopy can detect changes associated with the culture of human dental pulp stromal cells in osteoinductive culture

    Mitchell, A., Ashton, L., Yang, X. B., Goodacre, R., Tomlinson, M. J., Smith, A. & Kirkham, J., 10/09/2015, In: The Analyst. 140, 21, p. 7347-7354 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Making colourful sense of Raman images of single cells

    Ashton, L., Hollyowood, K. & Goodacre, R., 21/03/2015, In: Analyst. 140, 6, p. 1852-1858 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    UV resonance Raman spectroscopy: a process analytical tool for host cell DNA and RNA dynamics in mammalian cell lines

    Ashton, L., Hogwood, C. E. M., Tait, A. S., Kuligowski, J., Smales, C. M., Bracewell, D. G., Dickson, A. J. & Goodacre, R., 02/2015, In: Journal of Chemical Technology and Biotechnology. 90, 2, p. 237-243 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Detection of early stage changes associated with adipogenesis using Raman spectroscopy under aseptic conditions

    Mitchell, A., Ashton, L., Yang, X. B., Goodacre, R., Smith, A. & Kirkham, J., 2015, In: Cytometry Part A. 87, 11, p. 1012-1019 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. 2014
  23. Published

    Monitoring antibody aggregation in early drug development using Raman spectroscopy and perturbation-correlation moving windows

    Gómez de la Cuesta, R., Goodacre, R. & Ashton, L., 18/11/2014, In: Analytical Chemistry. 86, 22, p. 11133-11140 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Investigation of DMSO-induced conformational transitions in human serum albumin using two-dimensional Raman optical activity spectroscopy

    Batista, A. N. L., Batista, J. M., Ashton, L., Bolzani, V. S., Furlan, M. & Blanch, E. W., 09/2014, In: Chirality. 26, 9, p. 497-501 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    Raman spectroscopy can characterise the early stages of osteoinduction in dental pulp stromal cells

    Mighell, A., Ashton, L., Yang, X., Smith, A. & Kirkham, J., 06/2014, In: Journal of Tissue Engineering and Regenerative Medicine. 8, Supplement 1, p. 303-303 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  26. 2013
  27. Published

    Understanding glycoprotein behaviours using Raman and Raman optical activity spectroscopies: characterising the entanglement induced conformational changes in oligosaccharide chains of mucin

    Ashton, L., Pudney, P. D. A., Blanch, E. W. & Yakubov, G. E., 11/2013, In: Advances in Colloid and Interface Science. 199-200, p. 66-77 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    The challenge of applying Raman spectroscopy to monitor recombinant antibody production

    Ashton, L., Xu, Y., Brewster, V. L., Cowcher, D. P., Sellick, C. A., Dickson, A. J., Stephens, G. M. & Goodacre, R., 26/09/2013, In: Analyst. 138, 22, p. 6977-6985 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Monitoring Guanidinium-Induced Structural Changes in Ribonuclease Proteins Using Raman Spectroscopy and 2D Correlation Analysis

    Brewster, V. L., Ashton, L. & Goodacre, R., 2/04/2013, In: Analytical Chemistry. 85, 7, p. 3570-3575 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    Illuminating disease and enlightening biomedicine: Raman spectroscopy as a diagnostic tool

    Ellis, D. I., Cowcher, D. P., Ashton, L., O'Hagan, S. & Goodacre, R., 2013, In: Analyst. 138, 14, p. 3871-3884 14 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  31. 2011
  32. Published

    The importance of protonation in the investigation of protein phosphorylation using Raman spectroscopy and Raman optical activity

    Ashton, L., Johannessen, C. & Goodacre, R., 15/10/2011, In: Analytical Chemistry. 83, 20, p. 7978-7983 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    Raman spectroscopy: lighting up the future of microbial identification

    Ashton, L., Lau, K., Winder, C. L. & Goodacre, R., 09/2011, In: Future Microbiology. 6, 9, p. 991-997 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Monitoring the glycosylation status of proteins using Raman spectroscopy

    Brewster, V. L., Ashton, L. & Goodacre, R., 1/08/2011, In: Analytical Chemistry. 83, 15, p. 6074-6081 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Structural, spectroscopic and redox properties of uranyl complexes with a maleonitrile containing ligand

    Hardwick, H. C., Royal, D. S., Helliwell, M., Pope, S. J. A., Ashton, L., Goodacre, R. & Sharrad, C. A., 2011, In: Dalton Transactions. 40, 22, p. 5939-5952 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  36. 2010
  37. Published

    pH-induced conformational transitions in alpha-lactalbumin investigated with two-dimensional Raman correlation variance plots and moving windows

    Ashton, L. & Blanch, E. W., 16/06/2010, In: Journal of Molecular Structure. 974, 1-3, p. 132-138 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    Susceptibility of different proteins to flow-induced conformational changes monitored with Raman spectroscopy

    Ashton, L., Dusting, J., Imomoh, E., Balabani, S. & Blanch, E. W., 17/02/2010, In: Biophysical Journal. 98, 4, p. 707-714 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  39. 2009
  40. Published

    Shear-induced unfolding of lysozyme monitored in situ

    Ashton, L., Dusting, J., Imomoh, E., Balabani, S. & Blanch, E. W., 20/05/2009, In: Biophysical Journal. 96, 10, p. 4231-4236 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  41. 2008
  42. Published

    Investigations of conformational transitions in proteins and RNA using 2DCOS Raman and 2DCOS Raman optical activity spectroscopies

    Ashton, L., Hobro, A., Conn, G. L., Rouhi, M. & Blanch, E. W., 30/07/2008, In: Journal of Molecular Structure. 883-884, p. 187-194 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Investigation of polypeptide conformational transitions with two-dimensional Raman optical activity correlation analysis, applying autocorrelation and moving window approaches

    Ashton, L. & Blanch, E. W., 05/2008, In: Applied Spectroscopy. 62, 5, p. 469-475 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. 2007
  45. Published

    Two-dimensional Raman and Raman optical activity correlation analysis of the alpha-helix-to-disordered transition in poly(L-glutamic acid)

    Ashton, L., Barron, L. D., Hecht, L., Hyde, J. & Blanch, E. W., 05/2007, In: Analyst. 132, 5, p. 468-479 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  46. 2006
  47. Published

    Application of two-dimensional correlation analysis to Raman optical activity

    Ashton, L., Czarnik-Matusewicz, B. & Blanch, E. W., 6/11/2006, In: Journal of Molecular Structure. 799, 1-3, p. 61-71 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  48. Published

    Potential pitfalls concerning visualization of the 2D results

    Czarnik-Matusewicz, B., Pilorz, S., Ashton, L. & Blanch, E. W., 6/11/2006, In: Journal of Molecular Structure. 799, 1-3, p. 253-258 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    Two-dimensional correlation analysis of Raman optical activity data on the α-helix-to-β-sheet transition in poly(L-lysine)

    Ashton, L., Barron, L. D., Czarnik-matusewicz, B., Hecht, L., Hyde, J. & Blanch, E. W., 10/05/2006, In: Molecular Physics. 104, 9, p. 1429-1445 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  50. 2005
  51. Published

    Monitoring the mode of action of antibiotics using Raman spectroscopy: investigating subinhibitory effects of amikacin on Pseudomonas aeruginosa

    López-Diez, E. C., Winder, C. L., Ashton, L., Currie, F. & Goodacre, R., 1/05/2005, In: Analytical Chemistry. 77, 9, p. 2901-2906 6 p.

    Research output: Contribution to journalJournal articlepeer-review

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