Home > Research > Researchers > Dr Mick Urbaniak > Publications

Dr Mick Urbaniak

Senior Lecturer

  1. 2020
  2. Published

    Re-evaluation of Diadenosine Tetraphosphate (Ap4A) From a Stress Metabolite to Bona Fide Secondary Messenger

    Ferguson, F., Sandy McLennan, P., Urbaniak, M., Nigel Jones, D. & Copeland, N., 17/11/2020, In: Frontiers in Molecular Biosciences. 7, 18 p., 606807.

    Research output: Contribution to journalBook/Film/Article reviewpeer-review

  3. Published

    Phosphoproteomic analysis of mammalian infective Trypanosoma brucei subjected to heat shock suggests atypical mechanisms for thermotolerance

    Ooi, C. P., Benz, C. & Urbaniak, M., 15/05/2020, In: Journal of Proteomics. 219, 9 p., 103735.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Proteome-wide quantitative phosphoproteomic analysis of Trypanosoma brucei insect and mammalian lifecycle stages

    Benz, C. & Urbaniak, M., 30/03/2020, Trypanosomatids: Methods and Protocols. Michels, P. A. M., Ginger, M. L. & Zilberstein, D. (eds.). New York: Humana Press, p. 125-137 13 p. (Methods in Molecular Biology ; vol. 2116).

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter (peer-reviewed)peer-review

  5. E-pub ahead of print

    A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor

    Raimi, O. G., Hurtado-Guerrero, R., Borodkin, V., Ferenbach, A., Urbaniak, M., Ferguson, M. A. J. & van Aalten, D. M. F., 24/03/2020, In: RSC Chemical Biology. 2020, 1, p. 13-25 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  6. 2019
  7. Published

    Organising the cell cycle in the absence of transcriptional control: Dynamic phosphorylation co-ordinates the Trypanosoma brucei cell cycle post-transcriptionally

    Benz, C. & Urbaniak, M., 12/12/2019, In: PLoS Pathogens. 15, 12, 27 p., e1008129.

    Research output: Contribution to journalJournal articlepeer-review

  8. 2018
  9. Published

    Dynamic regulation of the Trypanosoma brucei transferrin receptor in response to iron starvation is mediated via the 3’UTR

    Benz, C., Lo, W., Fathallah, N., Connor-Guscott, A., Benns, H. J. & Urbaniak, M. D., 31/12/2018, In: PLoS ONE. 13, 12, 12 p., e0206332.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Development of chemical proteomics for the folateome and analysis of the kinetoplastid folateome

    Webster, L. A., Thomas, M., Urbaniak, M. D., Wyllie, S., Ong, H. B., Tinti, M., Fairlamb, A. H., Boesche, M., Ghidelli-Disse, S., Drewes, G. & Gilbert, I. H., 12/10/2018, In: ACS Infectious Diseases. 4, 10, p. 1475-1486 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis

    Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P., Albrecht, S. & 12 others, Berriman, M., Drewes, G., Gray, D. W., Ghidelli-Disse, S., Dixon, S., Fiandor, J. M., Wyatt, P. G., Ferguson, M. A. J., Fairlamb, A. H., Miles, T. J., Read, K. D. & Gilbert, I. H., 25/07/2018, In: Nature. 560, p. 192-197 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. 2017
  13. Published

    Cell cycle synchronisation of Trypanosoma brucei by centrifugal counter-flow elutriation reveals the timing of nuclear and kinetoplast DNA replication

    Benz, C., Dondelinger, F., McKean, P. G. & Urbaniak, M. D., 14/12/2017, In: Scientific Reports. 7, 10 p., 17599.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes

    Ivanova, I. M., Nepogodiev, S. A., Saalbach, G., O'Neill, E. C., Urbaniak, M. D., Ferguson, M. A. J., Gurcha, S. S., Besra, G. S. & Field, R. A., 13/01/2017, In: Carbohydrate Research. 438, p. 26-38 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  15. 2015
  16. Published

    Genomic and Proteomic Studies on the mode of action of Oxaboroles against the African Trypanosome

    Jones, D. C., Foth, B. J., Urbaniak, M. D., Patterson, S., Ong, H. B., Berriman, M. & Fairlamb, A. H., 18/12/2015, In: PLoS Neglected Tropical Diseases. 9, 12, 18 p., e0004299.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Molecular control of irreversible bistability during trypanosome developmental commitment

    Domingo Sananes, M. R., Szoor, B., Ferguson, M. A. J., Urbaniak, M. & Matthews, K. R., 19/10/2015, In: Journal of Cell Biology. 211, 2, p. 455-468 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes

    Sugden, C., Urbaniak, M. D., Araki, T. & Williams, J. G., 15/02/2015, In: Molecular Biology of the Cell. 26, 4, p. 805-820 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

    Shameer, S., Logan-Klumpler, F. J., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Bütikofer, P., Cattanach, A. M., Bannerman-Chukualim, B., Creek, D. J., Crouch, K., de Koning, H. P., Denise, H., Ebikeme, C., Fairlamb, A. H., Ferguson, M. A. J. & 21 others, Ginger, M. L., Hertz-Fowler, C., Kerkhoven, E. J., Mäser, P., Michels, P. A. M., Nayak, A., Nes, D. W., Nolan, D. P., Olsen, C., Silva-Franco, F., Smith, T. K., Taylor, M. C., Tielens, A. G. M., Urbaniak, M. D., van Hellemond, J. J., Vincent, I. M., Wilkinson, S. R., Wyllie, S., Opperdoes, F. R., Barrett, M. P. & Jourdan, F., 28/01/2015, In: Nucleic Acids Research. 43, D1, p. D637-D644 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  20. 2014
  21. Published

    Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase

    Urbaniak, M. D., Capes, A. S., Crossman, A., O'Neill, S., Thompson, S., Gilbert, I. H. & Ferguson, M. A. J., 31/03/2014, In: Carbohydrate Research. 387, p. 54-58 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    High-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics

    Güther, M. L. S., Urbaniak, M. D., Tavendale, A., Prescott, A. & Ferguson, M. A. J., 2014, In: Journal of Proteome Research. 13, 6, p. 2796-2806 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues

    Capes, A. S., Crossman, A., Urbaniak, M. D., Gilbert, S. H., Ferguson, M. A. J. & Gilbert, I. H., 2014, In: Organic and Biomolecular Chemistry . 2014, 12, p. 1919-1934 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Trypanosomatid Phosphoproteomics

    Urbaniak, M., 2014, Protein phosphorylation in parasites: novel targets for antiparasitic intervention. Doerig, C., Spath, G. & Wiese, M. (eds.). Chichester: Wiley Blackwell, p. 63-78 16 p. (Drug Discovery in Infectious Diseases).

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter

  25. 2013
  26. Published

    A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei.

    Urbaniak, M., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Hopkins Navratilova, I., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J., 20/09/2013, In: ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as a potential antifungal target

    Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Urbaniak, M., Ibrahim, A. F. M., Ferguson, M. A. J. & van Aalten, D. M. F., 08/2013, In: Molecular Microbiology. 89, 3, p. 479-493 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei

    Urbaniak, M., Ferguson, M. A. J. & Martin, D. M. A., 14/03/2013, In: Journal of Proteome Research. 12, p. 2233-2244 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  29. 2012
  30. Published

    Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei

    Urbaniak, M. D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M. A. J., Frearson, J. & Drewes, G., 16/11/2012, In: ACS Chemical Biology. 7, 11, p. 1858-1865 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages

    Urbaniak, M., Guther, M. L. S. & Ferguson, M. A. J., 4/05/2012, In: PLoS ONE. 7, 5, 8 p., e36619.

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness

    Abdelwahab, N. Z., Crossman, A. T., Sullivan, L., Ferguson, M. A. J. & Urbaniak, M., 03/2012, In: Chemical Biology and Drug Design. 79, 3, p. 270-278 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  33. 2011
  34. Published

    Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei

    Abdelwahab, N. Z., Urbaniak, M. D., Ferguson, M. A. J. & Crossman, A. T., 1/05/2011, In: Carbohydrate Research. 346, 6, p. 708-714 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  35. 2010
  36. Published

    Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness

    Durrant, J. D., Urbaniak, M. D., Ferguson, M. A. J. & McCammon, J. A., 8/07/2010, In: Journal of Medicinal Chemistry. 53, 13, p. 5025-5032 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology

    Durrant, J. D., Amaro, R. E., Xie, L., Urbaniak, M. D., Ferguson, M. A. J., Haapalainen, A., Chen, Z., Di Guilmi, A. M., Wunder, F., Bourne, P. E. & McCammon, J. A., 22/01/2010, In: PLoS Computational Biology. 6, 1, 8 p., e1000648.

    Research output: Contribution to journalJournal articlepeer-review

  38. 2009
  39. Published

    Chapter 3 The GlcNAc-PI de-N-acetylase. Structure, function, and activity

    Urbaniak, M. D. & Ferguson, M. A. J., 1/12/2009, In: Enzymes. 26, C, p. 49-64 16 p.

    Research output: Contribution to journalReview articlepeer-review

  40. Published

    Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei

    Urbaniak, M. D., 08/2009, In: Molecular and Biochemical Parasitology. 166, 2, p. 183-185 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  41. 2008
  42. Published

    Probing enzymes late in the trypanosomal glycosylphosphatidylinositol biosynthetic pathway with synthetic glycosylphosphatidylinositol analogues

    Urbaniak, M. D., Yashunsky, D. V., Crossman, A., Nikolaev, A. V. & Ferguson, M. A. J., 17/10/2008, In: ACS Chemical Biology. 3, 10, p. 625-634 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Probing Trypanosoma brucei glycosylphosphatidylinositol biosynthesis using novel precursor-analogues

    Urbaniak, M. D., Crossman, A. & Ferguson, M. A. J., 08/2008, In: Chemical Biology and Drug Design. 72, 2, p. 127-132 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis

    Crossman, A. T., Urbaniak, M. D. & Ferguson, M. A. J., 7/07/2008, In: Carbohydrate Research. 343, 9, p. 1478-1481 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  45. 2007
  46. Published

    Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic

    Baker, J. R., Woolfson, D. N., Muskett, F. W., Stoneman, R. G., Urbaniak, M. D. & Caddick, S., 7/05/2007, In: ChemBioChem. 8, 7, p. 704-717 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  47. 2006
  48. Published

    Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness

    Urbaniak, M. D., Tabudravu, J. N., Msaki, A., Matera, K. M., Brenk, R., Jaspars, M. & Ferguson, M. A. J., 15/11/2006, In: Bioorganic and Medicinal Chemistry Letters. 16, 22, p. 5744-5747 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant

    Urbaniak, M. D., Turnock, D. C. & Ferguson, M. A. J., 11/2006, In: Eukaryotic Cell. 5, 11, p. 1906-1913 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    Trypanosoma brucei UDP-galactose-4'-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose

    Alphey, M. S., Burton, A., Urbaniak, M. D., Boons, G-J., Ferguson, M. A. J. & Hunter, W. N., 1/09/2006, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 62, 9, p. 829-834 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  51. 2005
  52. Published

    The N-acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase of glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme

    Urbaniak, M. D., Crossman, A., Chang, T., Smith, T. K., van Aalten, D. M. F. & Ferguson, M. A. J., 17/06/2005, In: Journal of Biological Chemistry. 280, 24, p. 22831-22838 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  53. 2004
  54. Published

    Design and synthesis of a nitrogen mustard derivative stabilized by apo-neocarzinostatin

    Urbaniak, M. D., Bingham, J. P., Hartley, J. A., Woolfson, D. N. & Caddick, S., 9/09/2004, In: Journal of Medicinal Chemistry. 47, 19, p. 4710-4715 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  55. 2003
  56. Published

    Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore

    Urbaniak, M. D., Frost, L. M., Bingham, J. P., Kelland, L. R., Hartley, J. A., Woolfson, D. N. & Caddick, S., 16/06/2003, In: Bioorganic and Medicinal Chemistry Letters. 13, 12, p. 2025-2027 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  57. 2002
  58. Published

    Solution structure of a novel chromoprotein derived from apo-neocarzinostatin and a synthetic chromophore

    Urbaniak, M. D., Muskett, F. W., Finucane, M. D., Caddick, S. & Woolfson, D. N., 1/10/2002, In: Biochemistry. 41, 39, p. 11731-11739 9 p.

    Research output: Contribution to journalJournal articlepeer-review

Back to top