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Dr Mick Urbaniak

Lecturer

  1. 2017
  2. Published

    Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes

    Ivanova, I. M., Nepogodiev, S. A., Saalbach, G., O'Neill, E. C., Urbaniak, M. D., Ferguson, M. A. J., Gurcha, S. S., Besra, G. S. & Field, R. A. 13/01/2017 In : Carbohydrate Research. 438, p. 26-38 13 p.

    Research output: Contribution to journalJournal article

  3. 2015
  4. Published

    Genomic and Proteomic Studies on the mode of action of Oxaboroles against the African Trypanosome

    Jones, D. C., Foth, B. J., Urbaniak, M. D., Patterson, S., Ong, H. B., Berriman, M. & Fairlamb, A. H. 18/12/2015 In : PLoS Neglected Tropical Diseases. 9, 12, 18 p., e0004299

    Research output: Contribution to journalJournal article

  5. Published

    Molecular control of irreversible bistability during trypanosome developmental commitment

    Domingo Sananes, M. R., Szoor, B., Ferguson, M. A. J., Urbaniak, M. & Matthews, K. R. 19/10/2015 In : Journal of Cell Biology. 211, 2, p. 455-468 14 p.

    Research output: Contribution to journalJournal article

  6. Published

    The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes

    Sugden, C., Urbaniak, M. D., Araki, T. & Williams, J. G. 15/02/2015 In : Molecular Biology of the Cell. 26, 4, p. 805-820 16 p.

    Research output: Contribution to journalJournal article

  7. Published

    TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

    Urbaniak, M. D. & 40 others Shameer, S., Logan-Klumpler, F. J., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Bütikofer, P., Cattanach, A. M., Bannerman-Chukualim, B., Creek, D. J., Crouch, K., de Koning, H. P., Denise, H., Ebikeme, C., Fairlamb, A. H., Ferguson, M. A. J., Ginger, M. L., Hertz-Fowler, C., Kerkhoven, E. J., Mäser, P., Michels, P. A. M., Nayak, A., Nes, D. W., Nolan, D. P., Olsen, C., Silva-Franco, F., Smith, T. K., Taylor, M. C., Tielens, A. G. M., van Hellemond, J. J., Vincent, I. M., Wilkinson, S. R., Wyllie, S., Opperdoes, F. R., Barrett, M. P. & Jourdan, F. 28/01/2015 In : Nucleic Acids Research. 43, D1, p. D637-D644 8 p.

    Research output: Contribution to journalJournal article

  8. 2014
  9. Published

    Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase

    Urbaniak, M. D., Capes, A. S., Crossman, A., O'Neill, S., Thompson, S., Gilbert, I. H. & Ferguson, M. A. J. 31/03/2014 In : Carbohydrate Research. 387, p. 54-58 5 p.

    Research output: Contribution to journalJournal article

  10. Published

    High-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics

    Güther, M. L. S., Urbaniak, M. D., Tavendale, A., Prescott, A. & Ferguson, M. A. J. 2014 In : Journal of Proteome Research. 13, 6, p. 2796-2806 11 p.

    Research output: Contribution to journalJournal article

  11. Published

    Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues

    Capes, A. S., Crossman, A., Urbaniak, M. D., Gilbert, S. H., Ferguson, M. A. J. & Gilbert, I. H. 2014 In : Organic and Biomolecular Chemistry . 2014, 12, p. 1919-1934 16 p.

    Research output: Contribution to journalJournal article

  12. Published

    Trypanosomatid phosphoproteomics

    Urbaniak, M. 2014 Protein phosphorylation in parasites: novel targets for antiparasitic intervention. Doerig, C., Spath, G. & Wiese, M. (eds.). Chichester: Wiley Blackwell, p. 63-78 16 p. (Drug Discovery in Infectious Diseases)

    Research output: Contribution in Book/Report/ProceedingsChapter

  13. 2013
  14. Published

    A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei.

    Urbaniak, M., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Hopkins Navratilova, I., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J. 20/09/2013 In : ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

    Research output: Contribution to journalJournal article

  15. Published

    Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as a potential antifungal target

    Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Urbaniak, M., Ibrahim, A. F. M., Ferguson, M. A. J. & van Aalten, D. M. F. 08/2013 In : Molecular Microbiology. 89, 3, p. 479-493 15 p.

    Research output: Contribution to journalJournal article

  16. Published

    Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei

    Urbaniak, M., Ferguson, M. A. J. & Martin, D. M. A. 14/03/2013 In : Journal of Proteome Research. 12, p. 2233-2244 12 p.

    Research output: Contribution to journalJournal article

  17. 2012
  18. Published

    Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei

    Urbaniak, M. D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M. A. J., Frearson, J. & Drewes, G. 16/11/2012 In : ACS Chemical Biology. 7, 11, p. 1858-1865 8 p.

    Research output: Contribution to journalJournal article

  19. Published

    Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages

    Urbaniak, M., Guther, M. L. S. & Ferguson, M. A. J. 4/05/2012 In : PLoS ONE. 7, 5, 8 p., e36619

    Research output: Contribution to journalJournal article

  20. Published

    Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness

    Abdelwahab, N. Z., Crossman, A. T., Sullivan, L., Ferguson, M. A. J. & Urbaniak, M. 03/2012 In : Chemical Biology and Drug Design. 79, 3, p. 270-278 9 p.

    Research output: Contribution to journalJournal article

  21. 2011
  22. Published

    Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei

    Abdelwahab, N. Z., Urbaniak, M. D., Ferguson, M. A. J. & Crossman, A. T. 1/05/2011 In : Carbohydrate Research. 346, 6, p. 708-714 7 p.

    Research output: Contribution to journalJournal article

  23. 2010
  24. Published

    Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness

    Durrant, J. D., Urbaniak, M. D., Ferguson, M. A. J. & McCammon, J. A. 8/07/2010 In : Journal of Medicinal Chemistry. 53, 13, p. 5025-5032 8 p.

    Research output: Contribution to journalJournal article

  25. Published

    A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology

    Durrant, J. D., Amaro, R. E., Xie, L., Urbaniak, M. D., Ferguson, M. A. J., Haapalainen, A., Chen, Z., Di Guilmi, A. M., Wunder, F., Bourne, P. E. & McCammon, J. A. 22/01/2010 In : PLoS Computational Biology. 6, 1, 8 p., e1000648

    Research output: Contribution to journalJournal article

  26. 2009
  27. Published

    Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei

    Urbaniak, M. D. 08/2009 In : Molecular and Biochemical Parasitology. 166, 2, p. 183-185 3 p.

    Research output: Contribution to journalJournal article

  28. 2008
  29. Published

    Probing enzymes late in the trypanosomal glycosylphosphatidylinositol biosynthetic pathway with synthetic glycosylphosphatidylinositol analogues

    Urbaniak, M. D., Yashunsky, D. V., Crossman, A., Nikolaev, A. V. & Ferguson, M. A. J. 17/10/2008 In : ACS Chemical Biology. 3, 10, p. 625-634 10 p.

    Research output: Contribution to journalJournal article

  30. Published

    Probing Trypanosoma brucei glycosylphosphatidylinositol biosynthesis using novel precursor-analogues

    Urbaniak, M. D., Crossman, A. & Ferguson, M. A. J. 08/2008 In : Chemical Biology and Drug Design. 72, 2, p. 127-132 6 p.

    Research output: Contribution to journalJournal article

  31. Published

    Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis

    Crossman, A. T., Urbaniak, M. D. & Ferguson, M. A. J. 7/07/2008 In : Carbohydrate Research. 343, 9, p. 1478-1481 4 p.

    Research output: Contribution to journalJournal article

  32. 2007
  33. Published

    Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic

    Baker, J. R., Woolfson, D. N., Muskett, F. W., Stoneman, R. G., Urbaniak, M. D. & Caddick, S. 7/05/2007 In : ChemBioChem. 8, 7, p. 704-717 14 p.

    Research output: Contribution to journalJournal article

  34. 2006
  35. Published

    Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness

    Urbaniak, M. D., Tabudravu, J. N., Msaki, A., Matera, K. M., Brenk, R., Jaspars, M. & Ferguson, M. A. J. 15/11/2006 In : Bioorganic and Medicinal Chemistry Letters. 16, 22, p. 5744-5747 4 p.

    Research output: Contribution to journalJournal article

  36. Published

    Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant

    Urbaniak, M. D., Turnock, D. C. & Ferguson, M. A. J. 11/2006 In : Eukaryotic Cell. 5, 11, p. 1906-1913 8 p.

    Research output: Contribution to journalJournal article

  37. Published

    Trypanosoma brucei UDP-galactose-4'-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose

    Alphey, M. S., Burton, A., Urbaniak, M. D., Boons, G-J., Ferguson, M. A. J. & Hunter, W. N. 1/09/2006 In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 62, 9, p. 829-834 6 p.

    Research output: Contribution to journalJournal article

  38. 2005
  39. Published

    The N-acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase of glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme

    Urbaniak, M. D., Crossman, A., Chang, T., Smith, T. K., van Aalten, D. M. F. & Ferguson, M. A. J. 17/06/2005 In : Journal of Biological Chemistry. 280, 24, p. 22831-22838 8 p.

    Research output: Contribution to journalJournal article

  40. 2004
  41. Published

    Design and synthesis of a nitrogen mustard derivative stabilized by apo-neocarzinostatin

    Urbaniak, M. D., Bingham, J. P., Hartley, J. A., Woolfson, D. N. & Caddick, S. 9/09/2004 In : Journal of Medicinal Chemistry. 47, 19, p. 4710-4715 6 p.

    Research output: Contribution to journalJournal article

  42. 2003
  43. Published

    Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore

    Urbaniak, M. D., Frost, L. M., Bingham, J. P., Kelland, L. R., Hartley, J. A., Woolfson, D. N. & Caddick, S. 16/06/2003 In : Bioorganic and Medicinal Chemistry Letters. 13, 12, p. 2025-2027 3 p.

    Research output: Contribution to journalJournal article

  44. 2002
  45. Published

    Solution structure of a novel chromoprotein derived from apo-neocarzinostatin and a synthetic chromophore

    Urbaniak, M. D., Muskett, F. W., Finucane, M. D., Caddick, S. & Woolfson, D. N. 1/10/2002 In : Biochemistry. 41, 39, p. 11731-11739 9 p.

    Research output: Contribution to journalJournal article

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