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Dr Mohammed Rohaim

Postdoctoral Research Associate

Mohammed Rohaim

Furness Building

LA1 4YG

Lancaster

Research overview

My focus is to understand the innate immune responses in different hosts that range from sensing of viruses to terminal IFN effectors mediated by myriad of interferon-stimulated and virus-regulated genes. Employing large-scale, genome-wide and high-throughput screening platforms, my research is deciphering differential host responses to diverse viral pathogens and understanding the bases for genetic resistance/susceptibility of different avian species, virus-host cell interaction, especially how viral and cellular factors regulate the viral replication cycle; live cell imaging and viral replication compartments; virus assembly and involved host cell factors; mathematical modelling of virus replication and the race with the innate immune response; mechanism of viral RNA recognition by pattern recognition receptors; interferon response and viral counter measures; antiviral therapy and therapy resistance; mode-of-action of selected antiviral compounds. Additionally, applying genome-wide transcriptomics and proteomics approaches, my research is trying to understand molecular determinants of viral pathogenesis (infection) and the ways avian viruses (e.g. Newcastle disease virus and influenza viruses) have adapted to avoid innate immune responses in avian hosts. Likewise, other research focus is to investigating influenza virus evolution and defining the functional role of evolutionary changes on virus antigenicity, virulence, transmission and host-range, improving vaccines and vaccination strategies for effective control of influenza virus infection and developing reagents and assays for rapid detection and differentiation of virus subtypes. 

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