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Dr Morgan Gadd

North West Cancer Research (NWCR) Fellow

  1. 2018
  2. Published

    3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation

    Testa, A., Lucas, X., Castro, G. V., Chan, K-H., Wright, J. E., Runcie, A. C., Gadd, M. S., Harrison, W. T. A., Ko, E-J., Fletcher, D. & Ciulli, A., 25/07/2018, In : Journal of the American Chemical Society. 140, 29, p. 9299-9313 15 p.

    Research output: Contribution to journalJournal article

  3. Published

    Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

    Soares, P., Gadd, M. S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., Rocha, S., Read, K. D. & Ciulli, A., 25/01/2018, In : Journal of Medicinal Chemistry. 61, 2, p. 599-618 20 p.

    Research output: Contribution to journalJournal article

  4. 2017
  5. Published

    Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex

    Cardote, T. A. F., Gadd, M. S. & Ciulli, A., 6/06/2017, In : Structure. 25, 6, p. 901-911.e3 11 p.

    Research output: Contribution to journalJournal article

  6. Published

    Structural basis of PROTAC cooperative recognition for selective protein degradation

    Gadd, M. S., Testa, A., Lucas, X., Chan, K-H., Chen, W., Lamont, D. J., Zengerle, M. & Ciulli, A., 31/05/2017, In : Nature Chemical Biology. 13, 5, p. 514-521 8 p.

    Research output: Contribution to journalJournal article

  7. 2016
  8. Published

    Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

    Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., Read, K. D., Cantrell, D. A., Rocha, S. & Ciulli, A., 4/11/2016, In : Nature Communications. 7, 12 p., 13312.

    Research output: Contribution to journalJournal article

  9. 2015
  10. Published

    Biochemical and biophysical characterisation of haloalkane dehalogenases DmrA and DmrB in Mycobacterium strain JS60 and their role in growth on haloalkanes

    Fung, H. K. H., Gadd, M. S., Drury, T. A., Cheung, S., Guss, J. M., Coleman, N. V. & Matthews, J. M., 08/2015, In : Molecular Microbiology. 97, 3, p. 439-453 15 p.

    Research output: Contribution to journalJournal article

  11. Published
  12. 2014
  13. Published

    Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities.

    Galdeano, C., Gadd, M. S., Soares, P., Scaffidi, S., van Molle, I., Birced, I., Hewitt, S., Dias, D. M. & Ciulli, A., 23/10/2014, In : Journal of Medicinal Chemistry. 57, 20, p. 8657-8663 7 p.

    Research output: Contribution to journalJournal article

  14. 2013
  15. Published

    A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions.

    Gadd, M. S., Jacques, D. A., Nisevic, I., Craig, V. J., Kwan, A. H., Guss, J. M. & Matthews, J. M., 26/07/2013, In : Journal of Biological Chemistry. 228, p. 21924-21935 12 p.

    Research output: Contribution to journalJournal article

  16. 2012
  17. Published

    Crystallization and diffraction of an Isl1-Ldb1 complex.

    Gadd, M. S., Jacques, D. A., Guss, J. M. & Matthews, J. M., 1/11/2012, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 68, 11, p. 1398-1401 4 p.

    Research output: Contribution to journalJournal article

  18. Published

    Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions.

    Bhati, M., Lee, C., Gadd, M. S., Jeffries, C. M., Kwan, A. H., Whitten, A. E., Trewhella, J., Mackay, J. P. & Matthews, J. M., 25/07/2012, In : PLoS ONE. 7, 7, 9 p., e40719.

    Research output: Contribution to journalJournal article

  19. 2011
  20. Published

    Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.

    Gadd, M. S., Bhati, M., Jeffries, C. M., Langley, D. B., Trewhella, J., Guss, J. M. & Matthews, J. M., 16/12/2011, In : Journal of Biological Chemistry. 286, 50, p. 42971-42980 10 p.

    Research output: Contribution to journalJournal article

  21. 2009
  22. Published

    Crystallization and diffraction of an Lhx4–Isl2 complex.

    Gadd, M. S., Langley, D. B., Guss, J. M. & Matthews, J. M., 31/01/2009, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 65, 2, p. 151-153 3 p.

    Research output: Contribution to journalJournal article

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