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Research

Professor Paul McKean

Head of Department, Senior Lecturer

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  1. 1988
  2. Published

    Cuticle preparations from Necator americanus and their immunogenicity in the infected host.

    Pritchard, D. I., McKean, P. G. & Rogan, M. T., 04/1988, In: Molecular and Biochemical Parasitology. 28, 3, p. 275-283 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Cuticular collagens – a concealed target for immune attack in hookworms.

    Pritchard, D. I., McKean, P. G. & Rogan, M. T., 09/1988, In: Parasitology Today. 4, 9, p. 239-241 3 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. 1989
  5. Published

    The action of a mast cell protease on the cuticular collagens of Necator americanus.

    McKean, P. G. & Pritchard, D. I., 05/1989, In: Parasite Immunology. 11, 3, p. 293-297 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. 1990
  7. Published

    Epidemiology and immunology of Necator americanus infection in a community in Papua New Guinea: humoral responses to excretory-secretory and cuticular collagen antigens.

    Pritchard, D. I., Quinnell, R. J., Slater, A. F., McKean, P. G., Dale, D. D., Raiko, A. & Keymer, A. E., 1990, In: Parasitology. 100, 2, p. 317-326 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    An immunological and biochemical comparison of hookworm species.

    Pritchard, D. I., McKean, P. G. & Schad, G. A., 05/1990, In: Parasitology Today. 6, 5, p. 154-156 3 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    The identification of a species-specific antigen from Necator americanus.

    Pritchard, D. I., McKean, P. G., Rogan, M. T. & Schad, G. A., 05/1990, In: Parasite Immunology. 12, 3, p. 259-267 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    The epidemiological significance of the immune response to the cuticular collagen of Necator americanus : a preliminary study in a hookworm-endemic area in Papua New Guinea.

    Pritchard, D. I., Quinnell, R. J., Slater, A. F., McKean, P. G., Dale, D. D., Raiko, A. & Keymer, A. E., 07/1990, In: Acta Tropica. 47, 5-6, p. 403-407 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. 1991
  12. Published

    Hookworm (Necator americanus) infection and storage iron depletion.

    Pritchard, D. I., Quinnell, R. J., Moustafa, M., McKean, P. G., Slater, A. F., Raiko, A., Dale, D. D. & Keymer, A. E., 1991, In: Transactions of The Royal Society of Tropical Medicine and Hygiene. 85, 2, p. 235-238 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Recent and predicted advances in hookworm biology.

    Pritchard, D. I., McKean, P. G., Quinnell, R. J. & Tighe, P. J., 1991, Parasitic Nematodes: Membranes, Antigens and Genes.. Kennedy, M. W. (ed.). London: Taylor & Francis, p. 140-169 30 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter

  14. Published

    Necator americanus secretory acetylcholinesterase and its purification from excretory-secretory products by affinity chromatography.

    Pritchard, D. I., Leggett, K. V., Rogan, M. T., McKean, P. G. & Brown, A., 03/1991, In: Parasite Immunology. 13, 2, p. 187-199 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    Antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides in a community in Papua New Guinea infected predominantly with hookworm.

    Pritchard, D. I., Quinnell, R. J., McKean, P. G., Walsh, L., Leggett, K. V., Slater, A. F., Raiko, A., Dale, D. D. & Keymer, A. E., 07/1991, In: Transactions of The Royal Society of Tropical Medicine and Hygiene. 85, 4, p. 511-514 4 p.

    Research output: Contribution to Journal/Magazine › Journal article

  16. 1993
  17. Published

    A single amino acid determines the specificity of a monoclonal antibody which inhibits Plasmodium chabaudi AS in vivo.

    McKean, P. G., O'Dea, K. P. & Brown, K. N., 12/1993, In: Molecular and Biochemical Parasitology. 62, 2, p. 211-221 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    Nucleotide sequence analysis and epitope mapping of the merozoite surface protein 1 from Plasmodium chabaudi chabaudi AS.

    McKean, P. G., O’Dea, K. P. & Brown, K. N., 12/1993, In: Molecular and Biochemical Parasitology. 62, 2, p. 199-209 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. 1994
  20. Published

    Structure and function of infective stage proteins of Leishmania.

    Smith, D. F., Gokool, S., Keen, J. K., McKean, P. G. & Rangarajan, D., 1994, In: Biochemical Society Transactions. 22, 2, p. 286-291 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. 1995
  22. Published

    Processing of the Plasmodium chabaudi chabaudi AS merozite surface protein 1 in vivo and in vitro.

    O’Dea, K. P., McKean, P. G., Harris, A. & Brown, K. N., 06/1995, In: Molecular and Biochemical Parasitology. 72, 1-2, p. 111-119 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. 1996
  24. Published

    A single gene copy merozoite surface antigen and immune evasion?

    O’Dea, K. P., McKean, P. G., Jarra, W. & Brown, K. N., 04/1996, In: Parasite Immunology. 18, 4, p. 165-172 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. 1997
  26. Published

    Characterisation of a second protein encoded by the differentially regulated LmcDNA16 gene family of Leishmania major.

    McKean, P. G., Delahay, R., Pimenta, P. F. & Smith, D. F., 04/1997, In: Molecular and Biochemical Parasitology. 85, 2, p. 221-231 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  27. Published

    Diversity in repeat-containing surface proteins of Leishmania major.

    McKean, P. G., Trenholme, K. R., Rangarajan, D., Keen, J. K. & Smith, D. F., 06/1997, In: Molecular and Biochemical Parasitology. 86, 2, p. 225-235 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  28. 2000
  29. Published

    New tubulins in protozoal parasites.

    Vaughan, S., Attwood, T., Navarro, M., Scott, V., McKean, P. G. & Gull, K., 2000, In: Current Biology. 10, 7, p. R258-259

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  30. Published

    Molecular parasitology : new insights.

    McKean, P. G., Keen, J. K., Kelly, J. M. & Smith, D. F., 12/2000, In: Parasitology Today. 15, 12, p. 469-470 2 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  31. 2001
  32. Published

    Characterisation of a differentially expressed protein that shows an unusual localisation to intracellular membranes in Leishmania major.

    Kneupfer, E., Stierhof, Y. D., McKean, P. G. & Smith, D. F., 1/06/2001, In: Biochemical Journal. 356, 2, p. 335-344 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  33. Published

    Identification and characterisation of a RAD51 gene from Leishmania major.

    McKean, P. G., Keen, J. G., Smith, D. F. & Benson, F. E., 07/2001, In: Molecular and Biochemical Parasitology. 115, 2, p. 209-216 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  34. Published

    Phenotypic changes associated with deletion and over-expression of a stage-regulated gene family in Leishmania.

    McKean, P. G., Denny, P. W., Kneupfer, E., Keen, J. K. & Smith, D. F., 08/2001, In: Cellular Microbiology. 3, 8, p. 511-523 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  35. Published

    The extended tubulin superfamily.

    McKean, P. G., Vaughan, S. & Gull, K., 08/2001, In: Journal of Cell Science. 114, 15, p. 2723-2733 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  36. 2002
  37. Published

    Plasmodium chabaudi chabaudi AS: modification of acute infection in CBA/Ca mice as a result of pre-treatment with erythrocyte band 3 in adjuvant.

    O'Dea, K. P., McKean, P. G. & Brown, K. N., 10/2002, In: Experimental Parasitology. 102, 2, p. 66-71 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  38. 2003
  39. Published

    Myristoyl-CoA:Protein N-Myristoyltransferase, an Essential Enzyme and Potential Drug Target in Kinetoplastid Parasites.

    Price, H., Menon, M. R., Panethymitaki, C., Goulding, D., McKean, P. G. & Smith, D. F., 28/02/2003, In: Journal of Biological Chemistry. 278, 9, p. 7206-7214 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  40. Published

    γ-Tubulin Functions in the Nucleation of a Discrete Subset of Microtubules in the Eukaryotic Flagellum.

    McKean, P. G., Baines, A., Vaughan, S. & Gull, K., 1/04/2003, In: Current Biology. 13, 7, p. 598-602 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  41. Published

    Coordination of cell cycle progression and cytokinesis in Trypanosoma brucei.

    McKean, P. G., 12/2003, In: Current Opinion in Microbiology. 6, 6, p. 600-607 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  42. 2004
  43. Published

    The flagella connector of Trypanosoma brucei : an unusual mobile transmembrane junction.

    Briggs, L., McKean, P. G., Baines, A., Moreira-Leite, F., Davidge, J., Vaughan, S. & Gull, K., 04/2004, In: Journal of Cell Science. 117, 9, p. 1641-1651 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  44. 2006
  45. Published

    Trypanosome IFT mutants provide insight into the motor location for mobility of the flagella connector and flagella membrane formation.

    Davidge, J. A., Shawcross, E., Dickinson, H. A., Towers, K., Ginger, M. L., McKean, P. G. & Gull, K., 2006, In: Journal of Cell Science. 119, 19, p. 3935-3943 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  46. Published

    Flagellar motility is required for the viability of the bloodstream trypanosome.

    Broadhead, R., Dawe, H. R., Farr, H., Griffiths, S., Hart, S. R., Portman, N., Shaw, M. K., Ginger, M. L., Gaskell, S. J., McKean, P. G. & Gull, K., 9/03/2006, In: Nature. 440, 7081, p. 224-227 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  47. Published

    Basal body and flagellum mutants reveal a rotational constraint of the central pair microtubules in the axonemes of trypanosomes.

    Gadelha, C., Wickstead, B., McKean, P. G. & Gull, K., 15/06/2006, In: Journal of Cell Science. 119, 12, p. 2405-2413 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  48. 2007
  49. Published

    Cell structure, cell division and cell cycle.

    Hammarton, T., Wickstead, B. & McKean, P. G., 2007, Trypanosomes : after the genome. Barry, D., McCulloch, R., Mottram, J. & Acosta-Serrano, A. (eds.). Wymondham: Horizon Bioscience, p. 239-280 42 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter

  50. Published

    An essential quality control mechanism at the eukaryotic basal body prior to intraflagellar transport.

    Stephan, A., Vaughan, S., Shaw, M. K., Gull, K. & McKean, P. G., 10/2007, In: Traffic. 8, 10, p. 1323-1330 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  51. 2008
  52. Published

    Swimming with protists : perception, motility and flagellum assembly.

    Ginger, M. L., Portman, N. & McKean, P. G., 11/2008, In: Nature Reviews in Microbiology. 6, 11, p. 838-850 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  53. 2009
  54. Published

    Analysis of the trypanosome flagellar proteome using a combined electron transfer collisionally activated dissociation strategy.

    Hart, S. R., Wai Lau, K. W., Hao, Z., Broadhead, R., Portman, N., Huhmer, A., Gull, K., McKean, P. G., Hubbard, S. J. & Gaskell, S. J., 02/2009, In: Journal of The American Society for Mass Spectrometry. 20, 2, p. 167-175 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  55. Published

    Combining RNA interference mutants and comparative proteomics to identify protein component interactions and dependencies in a eukaryotic flagellum.

    Portman, N., Lacomble, S., Thomas, B., McKean, P. G. & Gull, K., 02/2009, In: Journal of Biological Chemistry. 284, 9, p. 5610-5619 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  56. 2010
  57. Published

    The flagellar pocket of trypanosomatids: a critical feature for cell morphogenesis and pathogenicity

    McKean, P. & Gull, K., 2010, Structures and organelles in pathogenic protists. de Souza, W. (ed.). Berlin: Springer Verlag, p. 87-113 27 p. (Microbiology Monographs; vol. 17).

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter (peer-reviewed)

  58. Published

    Flagellum function and assembly during the Leishmania life cycle.

    Gluenz, E., Ginger, M. L. & McKean, P. G., 08/2010, In: Current Opinion in Microbiology. 13, 4, p. 473-479 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  59. 2012
  60. Published

    Proteomic insights into parasite biology

    Ginger, M. L., McKean, P. G., Burchmore, R. & Grant, K. M., 08/2012, In: Parasitology. 139, 9, p. 1101-1102 2 p.

    Research output: Contribution to Journal/Magazine › Journal article

  61. 2013
  62. Published

    Tubulin-binding cofactor C domain-containing protein TBCCD1 orchestrates cytoskeletal filament formation

    Andre, J., Harrison, S., Towers, K., Qi, X., Vaughan, S., McKean, P. & Ginger, M., 12/2013, In: Journal of Cell Science. 126, p. 5350-5356 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  63. 2014
  64. Published

    An alternative model for the role of RP2 in flagellum assembly in the African trypanosome: RP2 function in T. brucei

    Andre, J., Kerry, L., Qi, X., Hawkins, E., Drižytė, K., Ginger, M. & McKean, P., 3/01/2014, In: Journal of Biological Chemistry. 289, 1, p. 464 –475 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  65. Published

    Eukaryotic flagella: variations in form, function, and composition during evolution

    Moran, J., McKean, P. & Ginger, M., 1/12/2014, In: Bioscience. 64, 12, p. 1103-1114 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  66. 2015
  67. Published

    Modulation of flagellum attachment zone protein FLAM3 and regulation of the cell shape in Trypanosoma brucei life cycle transitions

    Sunter, J. D., Benz, C., Andre, J., Whipple, S., McKean, P. G., Gull, K., Ginger, M. L. & Lukeš, J., 15/08/2015, In: Journal of Cell Science. 128, 16, p. 3117-3130 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  68. 2017
  69. Published

    Variation in Basal Body Localisation and Targeting of Trypanosome RP2 and FOR20 Proteins

    Harmer, J., Qi, X., Toniolo, G., Patel, A., Shaw, H., Benson, F. E., Ginger, M. L. & McKean, P. G., 08/2017, In: Protist. 168, 4, p. 452-466 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  70. Published

    Cell cycle synchronisation of Trypanosoma brucei by centrifugal counter-flow elutriation reveals the timing of nuclear and kinetoplast DNA replication

    Benz, C., Dondelinger, F., McKean, P. G. & Urbaniak, M. D., 14/12/2017, In: Scientific Reports. 7, 10 p., 17599.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  71. 2018
  72. Published

    A centriolar FGR1 oncogene partner-like protein required for paraflagellar rod assembly, but not axoneme assembly in African trypanosomes

    Harmer, J., Towers, K., Addison, M., Vaughan, S., Ginger, M. L. & McKean, P. G., 07/2018, In: Open biology. 8, 7, 13 p., 170218.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  73. 2021
  74. Published

    Redistribution of FLAgellar Member 8 during the trypanosome life cycle: Consequences for cell fate prediction

    Calvo-Álvarez, E., Bonnefoy, S., Salles, A., Benson, F. E., McKean, P. G., Bastin, P. & Rotureau, B., 30/09/2021, In: Cellular Microbiology. 23, 9, e13347.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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