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Research

Professor Paul McKean

Head of Department, Senior Lecturer

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  1. Chapter (peer-reviewed)
  2. Published

    The flagellar pocket of trypanosomatids: a critical feature for cell morphogenesis and pathogenicity

    McKean, P. & Gull, K., 2010, Structures and organelles in pathogenic protists. de Souza, W. (ed.). Berlin: Springer Verlag, p. 87-113 27 p. (Microbiology Monographs; vol. 17).

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter (peer-reviewed)

  3. Chapter
  4. Published

    Cell structure, cell division and cell cycle.

    Hammarton, T., Wickstead, B. & McKean, P. G., 2007, Trypanosomes : after the genome. Barry, D., McCulloch, R., Mottram, J. & Acosta-Serrano, A. (eds.). Wymondham: Horizon Bioscience, p. 239-280 42 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter

  5. Published

    Recent and predicted advances in hookworm biology.

    Pritchard, D. I., McKean, P. G., Quinnell, R. J. & Tighe, P. J., 1991, Parasitic Nematodes: Membranes, Antigens and Genes.. Kennedy, M. W. (ed.). London: Taylor & Francis, p. 140-169 30 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter

  6. Journal article
  7. Published

    Redistribution of FLAgellar Member 8 during the trypanosome life cycle: Consequences for cell fate prediction

    Calvo-Álvarez, E., Bonnefoy, S., Salles, A., Benson, F. E., McKean, P. G., Bastin, P. & Rotureau, B., 30/09/2021, In: Cellular Microbiology. 23, 9, e13347.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    A centriolar FGR1 oncogene partner-like protein required for paraflagellar rod assembly, but not axoneme assembly in African trypanosomes

    Harmer, J., Towers, K., Addison, M., Vaughan, S., Ginger, M. L. & McKean, P. G., 07/2018, In: Open biology. 8, 7, 13 p., 170218.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Cell cycle synchronisation of Trypanosoma brucei by centrifugal counter-flow elutriation reveals the timing of nuclear and kinetoplast DNA replication

    Benz, C., Dondelinger, F., McKean, P. G. & Urbaniak, M. D., 14/12/2017, In: Scientific Reports. 7, 10 p., 17599.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Variation in Basal Body Localisation and Targeting of Trypanosome RP2 and FOR20 Proteins

    Harmer, J., Qi, X., Toniolo, G., Patel, A., Shaw, H., Benson, F. E., Ginger, M. L. & McKean, P. G., 08/2017, In: Protist. 168, 4, p. 452-466 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    Modulation of flagellum attachment zone protein FLAM3 and regulation of the cell shape in Trypanosoma brucei life cycle transitions

    Sunter, J. D., Benz, C., Andre, J., Whipple, S., McKean, P. G., Gull, K., Ginger, M. L. & Lukeš, J., 15/08/2015, In: Journal of Cell Science. 128, 16, p. 3117-3130 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    Eukaryotic flagella: variations in form, function, and composition during evolution

    Moran, J., McKean, P. & Ginger, M., 1/12/2014, In: Bioscience. 64, 12, p. 1103-1114 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    An alternative model for the role of RP2 in flagellum assembly in the African trypanosome: RP2 function in T. brucei

    Andre, J., Kerry, L., Qi, X., Hawkins, E., Drižytė, K., Ginger, M. & McKean, P., 3/01/2014, In: Journal of Biological Chemistry. 289, 1, p. 464 –475 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    Tubulin-binding cofactor C domain-containing protein TBCCD1 orchestrates cytoskeletal filament formation

    Andre, J., Harrison, S., Towers, K., Qi, X., Vaughan, S., McKean, P. & Ginger, M., 12/2013, In: Journal of Cell Science. 126, p. 5350-5356 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    Proteomic insights into parasite biology

    Ginger, M. L., McKean, P. G., Burchmore, R. & Grant, K. M., 08/2012, In: Parasitology. 139, 9, p. 1101-1102 2 p.

    Research output: Contribution to Journal/Magazine › Journal article

  16. Published

    Flagellum function and assembly during the Leishmania life cycle.

    Gluenz, E., Ginger, M. L. & McKean, P. G., 08/2010, In: Current Opinion in Microbiology. 13, 4, p. 473-479 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    Combining RNA interference mutants and comparative proteomics to identify protein component interactions and dependencies in a eukaryotic flagellum.

    Portman, N., Lacomble, S., Thomas, B., McKean, P. G. & Gull, K., 02/2009, In: Journal of Biological Chemistry. 284, 9, p. 5610-5619 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    Analysis of the trypanosome flagellar proteome using a combined electron transfer collisionally activated dissociation strategy.

    Hart, S. R., Wai Lau, K. W., Hao, Z., Broadhead, R., Portman, N., Huhmer, A., Gull, K., McKean, P. G., Hubbard, S. J. & Gaskell, S. J., 02/2009, In: Journal of The American Society for Mass Spectrometry. 20, 2, p. 167-175 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Swimming with protists : perception, motility and flagellum assembly.

    Ginger, M. L., Portman, N. & McKean, P. G., 11/2008, In: Nature Reviews in Microbiology. 6, 11, p. 838-850 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    An essential quality control mechanism at the eukaryotic basal body prior to intraflagellar transport.

    Stephan, A., Vaughan, S., Shaw, M. K., Gull, K. & McKean, P. G., 10/2007, In: Traffic. 8, 10, p. 1323-1330 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    Basal body and flagellum mutants reveal a rotational constraint of the central pair microtubules in the axonemes of trypanosomes.

    Gadelha, C., Wickstead, B., McKean, P. G. & Gull, K., 15/06/2006, In: Journal of Cell Science. 119, 12, p. 2405-2413 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    Flagellar motility is required for the viability of the bloodstream trypanosome.

    Broadhead, R., Dawe, H. R., Farr, H., Griffiths, S., Hart, S. R., Portman, N., Shaw, M. K., Ginger, M. L., Gaskell, S. J., McKean, P. G. & Gull, K., 9/03/2006, In: Nature. 440, 7081, p. 224-227 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    Trypanosome IFT mutants provide insight into the motor location for mobility of the flagella connector and flagella membrane formation.

    Davidge, J. A., Shawcross, E., Dickinson, H. A., Towers, K., Ginger, M. L., McKean, P. G. & Gull, K., 2006, In: Journal of Cell Science. 119, 19, p. 3935-3943 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    The flagella connector of Trypanosoma brucei : an unusual mobile transmembrane junction.

    Briggs, L., McKean, P. G., Baines, A., Moreira-Leite, F., Davidge, J., Vaughan, S. & Gull, K., 04/2004, In: Journal of Cell Science. 117, 9, p. 1641-1651 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    Coordination of cell cycle progression and cytokinesis in Trypanosoma brucei.

    McKean, P. G., 12/2003, In: Current Opinion in Microbiology. 6, 6, p. 600-607 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  26. Published

    γ-Tubulin Functions in the Nucleation of a Discrete Subset of Microtubules in the Eukaryotic Flagellum.

    McKean, P. G., Baines, A., Vaughan, S. & Gull, K., 1/04/2003, In: Current Biology. 13, 7, p. 598-602 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  27. Published

    Myristoyl-CoA:Protein N-Myristoyltransferase, an Essential Enzyme and Potential Drug Target in Kinetoplastid Parasites.

    Price, H., Menon, M. R., Panethymitaki, C., Goulding, D., McKean, P. G. & Smith, D. F., 28/02/2003, In: Journal of Biological Chemistry. 278, 9, p. 7206-7214 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  28. Published

    Plasmodium chabaudi chabaudi AS: modification of acute infection in CBA/Ca mice as a result of pre-treatment with erythrocyte band 3 in adjuvant.

    O'Dea, K. P., McKean, P. G. & Brown, K. N., 10/2002, In: Experimental Parasitology. 102, 2, p. 66-71 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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