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Professor Thomas Jaki

Professor in Statistics

  1. 2019
  2. Published

    A flexible design for advanced Phase I/II clinical trials with continuous efficacy endpoints

    Mozgunov, P. & Jaki, T., 1/11/2019, In : Biometrical Journal. 61, 6, p. 1477-1492 16 p.

    Research output: Contribution to journalJournal article

  3. Published

    Subgroup analysis of treatment effects for misclassified biomarkers with time-to-event data

    Wan, F., Titman, A. & Jaki, T., 1/11/2019, In : Journal of the Royal Statistical Society. Series C: Applied Statistics. 68, 5, p. 1447-1463 17 p.

    Research output: Contribution to journalJournal article

  4. Published

    Loss Functions in Restricted Parameter Spaces and Their Bayesian Applications

    Mozgunov, P., Jaki, T. F. & Gasparini, M., 3/10/2019, In : Journal of Applied Statistics. 46, 13, p. 2314-2337 24 p.

    Research output: Contribution to journalJournal article

  5. Published

    A novel measure of drug benefit–risk assessment based on Scale Loss Score

    Saint-Hilary, G., Robert, V., Gasparini, M., Jaki, T. F. & Mozgunov, P., 1/09/2019, In : Statistical Methods in Medical Research. 28, 9, p. 2738-2753 16 p.

    Research output: Contribution to journalJournal article

  6. Published

    A Bayesian model to estimate the cutoff and the clinical utility of a biomarker assay

    Vradi, E., Jaki, T. F., Vonk, R. & Brannath, W., 1/08/2019, In : Statistical Methods in Medical Research. 28, 8, p. 2538-2556 19 p.

    Research output: Contribution to journalJournal article

  7. Published

    Bayesian sequential integration within a preclinical pharmacokinetic and pharmacodynamic modeling framework: Lessons learned

    La Gamba, F., Jacobs, T., Geys, H., Jaki, T., Serroyen, J., Ursino, M., Russu, A. & Faes, C., 1/07/2019, In : Pharmaceutical Statistics. 18, 4, p. 486-506 21 p.

    Research output: Contribution to journalJournal article

  8. Published

    Model-Based dose escalation Designs in R with crmPack

    Bové, D. S., Yeung, W. Y., Palermo, G. & Jaki, T., 13/06/2019, In : Journal of Statistical Software. 89, 10, 22 p.

    Research output: Contribution to journalJournal article

  9. E-pub ahead of print

    Repeated measures regression mixture models

    Kim, M., Van Horn, M. L., Jaki, T., Vermunt, J., Feaster, D., Lichstein, K. L., Taylor, D. J., Riedel, B. W. & Bush, A. J., 31/05/2019, In : Behavior Research Methods.

    Research output: Contribution to journalJournal article

  10. Published

    Response to comments on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharm Stat 17(5):593-606, Sep/Oct 2018., DOI https://doi.org/10.1002/pst.1873

    Jaki, T., Gordon, A., Forster, P., Bijnens, L., Bornkamp, B., Brannath, W., Fontana, R., Gasparini, M., Hampson, L. V., Jacobs, T., Jones, B., Paoletti, X., Posch, M., Titman, A., Vonk, R. & Koenig, F., 1/05/2019, In : Pharmaceutical Statistics. 18, 3, p. 284-286 3 p.

    Research output: Contribution to journalLetter

  11. Published

    The effects of sample size on the estimation of regression mixture models

    Jaki, T. F., Kim, M., Lamont, A. E., George, M., Feaster, D. & Van Horn, M. L., 1/04/2019, In : Educational and Psychological Measurement. 79, 2, p. 358-384 27 p.

    Research output: Contribution to journalJournal article

  12. Published

    Instrumental variable estimation in semi-parametric additive hazards models

    Brueckner, M., Titman, A. C. & Jaki, T. F., 1/03/2019, In : Biometrics. 75, 1, p. 110-120 11 p.

    Research output: Contribution to journalJournal article

  13. Published

    The R package MAMS for designing multi-arm multi-stage clinical trials

    Jaki, T. F., Pallmann, P. S. & Magirr, D., 31/01/2019, In : Journal of Statistical Software. 88, 4, 25 p.

    Research output: Contribution to journalJournal article

  14. Published

    How to design a dose-finding study using the continual reassessment method

    Wheeler, G. M., Mander, A. P., Bedding, A., Brock, K., Cornelius, V., Grieve, A. P., Jaki, T., Love, S. B., Odondi, L., Weir, C. J., Yap, C. & Bond, S. J., 18/01/2019, In : BMC Medical Research Methodology. 19, 1, 15 p., 18.

    Research output: Contribution to journalJournal article

  15. Published

    Editorial for the MCP 2017 Special Issue

    Cui, X., Hsu, J. C. & Jaki, T., 11/01/2019, In : Biometrical Journal. 61, 1, p. 7 1 p.

    Research output: Contribution to journalEditorial

  16. Published

    Confidence regions for treatment effects in subgroups in biomarker stratified designs

    Wan, F., Kunz, C. U. & Jaki, T. F., 1/01/2019, In : Biometrical Journal. 61, 1, p. 27-39 13 p.

    Research output: Contribution to journalJournal article

  17. 2018
  18. Published

    An alternative method to analyse the Biomarker-strategy design

    Kunz, C. U., Jaki, T. F. & Stallard, N., 30/12/2018, In : Statistics in Medicine. 37, 30, p. 4636-4651 16 p.

    Research output: Contribution to journalJournal article

  19. Published

    Design and estimation in clinical trials with subpopulation selection

    Chiu, Y-D., Koenig, F., Posch, M. & Jaki, T. F., 20/12/2018, In : Statistics in Medicine. 37, 29, p. 4335-4352 18 p.

    Research output: Contribution to journalJournal article

  20. Published

    Multi-arm multi-stage trials can improve the efficiency of finding effective treatments for stroke: a case study

    Jaki, T. & Wason, J. M. S., 27/11/2018, In : BMC Cardiovascular Disorders. 18, 1, 8 p., 215.

    Research output: Contribution to journalJournal article

  21. Published

    Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design

    Dimairo, M., Coates, E., Pallmann, P., Todd, S., Julious, S. A., Jaki, T., Wason, J., Mander, A. P., Weir, C. J., Koenig, F., Walton, M. K., Biggs, K., Nicholl, J., Hamasaki, T., Proschan, M. A., Scott, J. A., Ando, Y., Hind, D. & Altman, D. G., 16/11/2018, In : BMC Medicine. 16, 1, 20 p.

    Research output: Contribution to journalJournal article

  22. E-pub ahead of print

    Randomized dose-escalation designs for drug combination cancer trials with immunotherapy

    Mozgunov, P., Jaki, T. F. & Paoletti, X., 23/10/2018, In : Journal of Biopharmaceutical Statistics. 29, 2, p. 359-377 19 p.

    Research output: Contribution to journalJournal article

  23. Published

    Subgroup identification in clinical trials via the predicted individual treatment effect

    Ballarini, N. M., Rosenkranz, G. K., Jaki, T., König, F. & Posch, M., 18/10/2018, In : PLoS ONE. 13, 10, 22 p., e0205971.

    Research output: Contribution to journalJournal article

  24. Published

    Performance of different clinical trial designs to evaluate treatments during an epidemic

    Brueckner, M., Titman, A. C., Jaki, T. F., Rojek, A. & Horby, P. W., 11/09/2018, In : PLoS ONE. 13, 9, 19 p., e0203387.

    Research output: Contribution to journalJournal article

  25. Published

    A proposal for a new PhD level curriculum on quantitative methods for drug development

    Jaki, T. F., Gordon, A., Forster, P. S., Bijnens, L., Bornkamp, B., Brannath, W., Fontana, R., Gasparini, M., Hampson, L. V., Jacobs, T., Jones, B., Paoletti, X., Posch, M., Titman, A. C., Vonk, R. & Koenig, F., 09/2018, In : Pharmaceutical Statistics. 17, 5, p. 593-606 14 p.

    Research output: Contribution to journalJournal article

  26. Published

    Dose-escalation strategies which utilise subgroup information

    Cotterill, A. & Jaki, T. F., 09/2018, In : Pharmaceutical Statistics. 17, 5, p. 414-436 13 p.

    Research output: Contribution to journalJournal article

  27. E-pub ahead of print

    A benchmark for dose finding studies with continuous outcomes

    Mozgunov, P., Jaki, T. F. & Paoletti, X., 24/08/2018, In : Biostatistics. 13 p.

    Research output: Contribution to journalJournal article

  28. Published

    Model selection based on combined penalties for biomarker identification

    Vradi, E., Brannath, W., Jaki, T. & Vonk, R., 4/07/2018, In : Journal of Biopharmaceutical Statistics. 28, 4, p. 735-749 15 p.

    Research output: Contribution to journalJournal article

  29. E-pub ahead of print

    An information-theoretic Phase I/II design for molecularly targeted agents that does not require an assumption of monotonicity

    Mozgunov, P. & Jaki, T. F., 15/06/2018, In : Journal of the Royal Statistical Society: Series C (Applied Statistics). 68, 2, p. 347-367 21 p.

    Research output: Contribution to journalJournal article

  30. Published

    A review of the deterministic and diffusion approximations for stochastic chemical reaction networks

    Mozgunov, P., Beccuti, M., Horvath, A., Jaki, T. F., Sirovich, R. & Bibbona, E., 04/2018, In : Reaction Kinetics, Mechanisms and Catalysis. 123, 2, p. 289-312 24 p.

    Research output: Contribution to journalJournal article

  31. Published

    Extrapolation of efficacy and other data to support the development of new medicines for children: a systematic review of methods

    Wadsworth, I., Hampson, L. V. & Jaki, T. F., 1/02/2018, In : Statistical Methods in Medical Research. 27, 2, p. 398-413 16 p.

    Research output: Contribution to journalJournal article

  32. Published

    A review of statistical updating methods for clinical prediction models

    Su, T-L., Jaki, T. F., Hickey, G., Buchan, I. & Sperrin, M., 1/01/2018, In : Statistical Methods in Medical Research. 27, 1, p. 185-197 13 p.

    Research output: Contribution to journalJournal article

  33. Published

    Identification of Predicted Individual Treatment Effects (PITE) in randomized clinical trials

    Lamont, A. E., Lyons, M., Jaki, T. F., Stuart, E. A., Feaster, D., Ishwaran, H., Tharmaratnam, K. & Van Horn, M. L., 1/01/2018, In : Statistical Methods in Medical Research. 27, 1, p. 142-157 16 p.

    Research output: Contribution to journalJournal article

  34. Published

    Optimal Designs for Non-Compartmental Analysis of Pharmacokinetic Studies

    Barnett, H. Y., Geys, H., Jacobs, T. & Jaki, T. F., 2018, In : Statistics in Biopharmaceutical Research. 10, 4, p. 255-263 9 p.

    Research output: Contribution to journalJournal article

  35. 2017
  36. Published

    Simultaneous confidence regions for multivariate bioequivalence

    Pallmann, P. S. & Jaki, T. F., 20/12/2017, In : Statistics in Medicine. 36, 29, p. 4585-4603 19 p.

    Research output: Contribution to journalJournal article

  37. Published

    Comparing sampling methods for pharmacokinetic studies using model averaged derived parameters

    Barnett, H. Y., Geys, H., Jacobs, T. & Jaki, T., 30/11/2017, In : Statistics in Medicine. 36, 27, p. 4301-4315 15 p.

    Research output: Contribution to journalJournal article

  38. Published

    Estimation in multi-arm two-stage trials with treatment selection and time-to-event endpoint

    Brueckner, M., Titman, A. C. & Jaki, T. F., 10/09/2017, In : Statistics in Medicine. 36, 20, p. 3137-3153 17 p.

    Research output: Contribution to journalJournal article

  39. Published

    A Bayesian adaptive design for clinical trials in rare diseases

    Williamson, F., Jacko, P., Villar, S. S. & Jaki, T. F., 09/2017, In : Computational Statistics and Data Analysis. 113, p. 136-153 17 p.

    Research output: Contribution to journalJournal article

  40. Published

    Factorial versus multi-arm multi-stage designs for clinical trials with multiple treatments

    Jaki, T. F. & Vasileiou, D., 20/02/2017, In : Statistics in Medicine. 36, 4, p. 563-580 8 p.

    Research output: Contribution to journalJournal article

  41. Published

    Asymmetric inner wedge group sequential tests with applications to verifying whether effective drug concentrations are similar in adults and children

    Hampson, L. V., Fisch, R., Van, L. M. & Jaki, T. F., 10/02/2017, In : Statistics in Medicine. 36, 3, p. 426-441 16 p.

    Research output: Contribution to journalJournal article

  42. 2016
  43. Published

    Clinical drug development in epilepsy revisited: a proposal for a new paradigm streamlined using extrapolation

    Wadsworth, I., Jaki, T. F., Sills, G. J., Appleton, R., Cross, J. H., Marson, A. G., Martland, T., McLellan, A., Smith, P. E. M., Pellock, J. M. & Hampson, L. V., 11/2016, In : CNS Drugs. 30, 11, p. 1011-1017 7 p.

    Research output: Contribution to journalJournal article

  44. Published

    A false sense of security? can tiered approach be trusted to accurately classify immunogenicity samples?

    Jaki, T. F., Allacher, P. & Horling, F., 5/09/2016, In : Journal of Pharmaceutical and Biomedical Analysis. 128, p. 166-173 8 p.

    Research output: Contribution to journalJournal article

  45. Published

    Tilting the lasso by knowledge-based post-processing

    Tharmaratnam, K., Sperrin, M., Jaki, T. F., Reppe, S. & Frigessi, A., 2/09/2016, In : BMC Bioinformatics. 17, 9 p., 344.

    Research output: Contribution to journalJournal article

  46. Published

    Understanding clinical prediction models as ‘innovations’: a mixed methods study in UK family practice

    Brown, B., Cheraghi-Sohi, S., Jaki, T. F., Su, T-L., Buchan, I. & Sperrin, M., 9/08/2016, In : BMC Medical Informatics and Decision Making. 16, 13 p., 106.

    Research output: Contribution to journalJournal article

  47. Published

    Why are two mistakes not worse than one? a proposal for controlling the expected number of false claims

    Jaki, T. F. & Parry, A., 07/2016, In : Pharmaceutical Statistics. 15, 4, p. 362-367 6 p.

    Research output: Contribution to journalJournal article

  48. Published

    A review of statistical designs for improving the efficiency of phase II studies in oncology

    Wason, J. & Jaki, T., 06/2016, In : Statistical Methods in Medical Research. 25, 3, p. 1010-1021 12 p.

    Research output: Contribution to journalJournal article

  49. Published

    Impact of an equality constraint on the class-specific residual variances in regression mixtures: a Monte Carlo simulation study

    Kim, M., Lamont, A. E., Jaki, T., Feaster, D., Howe, G. & Van Horn, M. L., 06/2016, In : Behavior Research Methods. 48, 2, p. 813-826 14 p.

    Research output: Contribution to journalJournal article

  50. Published

    Modeling predictors of latent classes in regression mixture models

    Kim, M., Vermunt, J., Bakk, Z., Jaki, T. F. & Van Horn, M. L., 06/2016, In : Structural Equation Modeling. 23, 4, p. 601-614 14 p.

    Research output: Contribution to journalJournal article

  51. Published

    Some recommendations for multi-arm multi-stage trials

    Wason, J., Magirr, D., Law, M. & Jaki, T., 04/2016, In : Statistical Methods in Medical Research. 25, 2, p. 716-727 12 p.

    Research output: Contribution to journalJournal article

  52. Published

    Designing multi-arm multi-stage clinical trials using a risk-benefit criterion for treatment selection

    Jaki, T. & Hampson, L., 20/02/2016, In : Statistics in Medicine. 35, 4, p. 522-533 12 p.

    Research output: Contribution to journalJournal article

  53. Published

    Sample size reassessment and hypothesis testing in adaptive survival trials

    Magirr, D., Jaki, T. F., Koenig, F. & Posch, M., 10/02/2016, In : PLoS ONE. 11, 2, 14 p., e0146465.

    Research output: Contribution to journalJournal article

  54. Published

    Using multilevel regression mixture models to identify level-1 heterogeneity in level-2 effects

    Van Horn, M. L., Feng, Y., Kim, M., Lamont, A. E., Feaster, D. & Jaki, T., 2016, In : Structural Equation Modeling. 23, 2, p. 259-269 11 p.

    Research output: Contribution to journalJournal article

  55. 2015
  56. Published

    Bayesian adaptive dose-escalation procedures for binary and continuous responses utilizing a gain function

    Yeung, W. Y., Whitehead, J. R., Reigner, B., Beyer, U., Diack, C. & Jaki, T. F., 11/2015, In : Pharmaceutical Statistics. 14, 6, p. 479-487 9 p.

    Research output: Contribution to journalJournal article

  57. Published

    Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of Telmisartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on combination antiretroviral therapy

    Pushpakom, S. P., Taylor, C., Kolamunnage-Dona, R., Spowart, C., Vora, J., Garcıa-Finana, M., Kemp, G. J., Whitehead, J., Jaki, T., Khoo, S., Williamson, P. & Pirmohamed, M., 15/10/2015, In : BMJ Open. 5, 10, 13 p., e009566.

    Research output: Contribution to journalJournal article

  58. Published

    Evaluating differential effects using regression interactions and regression mixture models

    Van Horn, M. L., Jaki, T., Maysn, K., Howe, G., Feaster, D., Lamont, A. E., George, M. & Kim, M., 08/2015, In : Educational and Psychological Measurement. 75, 4, p. 677-714 38 p.

    Research output: Contribution to journalJournal article

  59. Published

    A practical design for a dual-agent dose-escalation trial that incorporates pharmacokinetic data

    Cotterill, A., Lorand, D., Wang, J. & Jaki, T., 15/06/2015, In : Statistics in Medicine. 34, 13, p. 2138-2164 27 p.

    Research output: Contribution to journalJournal article

  60. Published

    Adaptive clinical trials in tuberculosis: applications, challenges and solutions

    Davis, G. R., Phillips, P. P. & Jaki, T., 1/06/2015, In : International Journal of Tuberculosis and Lung Disease. 19, 6, p. 626-634 9 p.

    Research output: Contribution to journalJournal article

  61. Published

    Multi-arm clinical trials with treatment selection: what can be gained and at what price?

    Jaki, T., 04/2015, In : Clinical Investigation. 5, 4, p. 393-399 7 p.

    Research output: Contribution to journalJournal article

  62. Published

    Statistical approaches for the determination of cut points in anti-drug antibody bioassays

    Schaarschmidt, F., Hofmann, M., Jaki, T., Gruen, B. & Hothorn, L. A., 03/2015, In : Journal of Immunological Methods. 418, p. 84-100 17 p.

    Research output: Contribution to journalJournal article

  63. 2014
  64. Published

    Flexible sequential designs for multi-arm clinical trials

    Magirr, D., Stallard, N. & Jaki, T., 30/08/2014, In : Statistics in Medicine. 33, 19, p. 3269-3279 11 p.

    Research output: Contribution to journalJournal article

  65. Published

    A comparison of methods for classifying samples as truly specific with confirmatory immunoassays

    Jaki, T., Lawo, J-P., Wolfsegger, M. J., Allacher, P. & Horling, F., 25/01/2014, In : Journal of Pharmaceutical and Biomedical Analysis. 88, p. 27-35 9 p.

    Research output: Contribution to journalJournal article

  66. Published

    A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships

    Wolfsegger, M. J., Gutjahr, G., Engl, W. & Jaki, T., 2014, In : Biometrics. 70, 1, p. 103-109 7 p.

    Research output: Contribution to journalJournal article

  67. Published

    Designing multi-arm multi-stage clinical studies

    Jaki, T., 2014, Developments in statistical evaluation of clinical trials. van Montfort, K., Oud, J. & Ghidey, W. (eds.). Berlin: Springer, p. 51-69 19 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter (peer-reviewed)

  68. Published

    Statistical evaluation of toxicological assays with zero or near-to-zero proportions or counts in the concurrent negative control group: a tutorial

    Jaki, T., Kitsche, A. & Hothorn, L. A., 2014, In : JP Journal of Biostatistics. 11, 1, p. 1-32 32 p.

    Research output: Contribution to journalJournal article

  69. 2013
  70. Published

    Authors' reply to comments on "Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data settings"

    Jaki, T., Pallmann, P. & Wolfsegger, M. J., 30/12/2013, In : Statistics in Medicine. 32, 30, p. 5487-5488 2 p.

    Research output: Contribution to journalComment/debate

  71. Published

    Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs

    Jaki, T., Pallmann, P. & Wolfsegger, M. J., 30/12/2013, In : Statistics in Medicine. 32, 30, p. 5469-5483 15 p.

    Research output: Contribution to journalJournal article

  72. Published

    Statistical evaluation of toxicological assays: Dunnett or Williams test? − take both

    Jaki, T. & Hothorn, L. A., 11/2013, In : Archives of Toxicology. 87, 11, p. 1901-1910 10 p.

    Research output: Contribution to journalJournal article

  73. Published

    Planning multi-arm screening studies within the context of a drug development programme

    Wason, J., Jaki, T. & Stallard, N., 10/09/2013, In : Statistics in Medicine. 32, 20, p. 3424-3435 12 p.

    Research output: Contribution to journalJournal article

  74. Published

    Differential effects of parental controls on adolescent substance use: for whom is the family most important?

    Fagan, A. A., Van Horn, M. L., Hawkins, J. D. & Jaki, T., 09/2013, In : Journal of Quantitative Criminology. 29, 3, p. 347-368 22 p.

    Research output: Contribution to journalJournal article

  75. Published

    Multiplicity: discussion points from the PSI multiplicity expert group

    Phillips, A., Fletcher, C., Atkinson, G., Channon, E., Douiri, A., Jaki, T., Maca, J., Morgan, D., Roger, J. H. & Terrill, P., 09/2013, In : Pharmaceutical Statistics. 12, 5, p. 255-259 5 p.

    Research output: Contribution to journalJournal article

  76. Published

    Analysing malaria drug trials on a per individual or a per clone basis: a comparison of methods

    Jaki, T., Parry, A., Winter, K. & Hastings, I., 30/07/2013, In : Statistics in Medicine. 32, 17, p. 3020-3038 19 p.

    Research output: Contribution to journalJournal article

  77. Published

    Designing exploratory cancer trials using change in tumour size as primary endpoint

    Jaki, T., Andre, V., Su, T-L. & Whitehead, J., 10/07/2013, In : Statistics in Medicine. 32, 15, p. 2544-2554 11 p.

    Research output: Contribution to journalJournal article

  78. Published

    Principles of dose finding studies in cancer: a comparison of trial designs

    Jaki, T., Clive, S. & Weir, C., 05/2013, In : Cancer Chemotherapy and Pharmacology. 71, 5, p. 1107-1114 8 p.

    Research output: Contribution to journalJournal article

  79. Published

    Uptake of novel statistical methods for early phase clinical studies in the UK public sector

    Jaki, T., 04/2013, In : Clinical Trials. 10, 2, p. 344-346 3 p.

    Research output: Contribution to journalJournal article

  80. Published

    Considerations on covariates and endpoints in multi-arm multi-stage clinical trials selecting all promising treatments

    Jaki, T. & Magirr, D., 30/03/2013, In : Statistics in Medicine. 32, 7, p. 1150-1163 14 p.

    Research output: Contribution to journalJournal article

  81. Published

    Finite mixtures for simultaneously modelling differential effects and non-normal distributions

    George, M., Yang, N., Jaki, T., Feaster, D., Lamont, A. E., Van Horn, M. L. & Wilson, D. K., 2013, In : Multivariate Behavioral Research. 48, 6, p. 816-844 29 p.

    Research output: Contribution to journalJournal article

  82. Published

    Simultaneous confidence intervals that are compatible with closed testing in adaptive designs

    Magirr, D., Jaki, T., Posch, M. & Klingelmueller, F., 2013, In : Biometrika. 100, 4, p. 985-996 12 p.

    Research output: Contribution to journalJournal article

  83. Published

    Using regression mixture models with non-normal data: examining an ordered polytomous approach

    George, M., Yang, N., Van Horn, M. L., Smith, J., Jaki, T., Feaster, D., Maysn, K. & Howe, G., 2013, In : Journal of Statistical Computation and Simulation. 83, 4, p. 757-770 14 p.

    Research output: Contribution to journalJournal article

  84. 2012
  85. Published

    Optimal design of multi-arm multi-stage trials

    Wason, J. & Jaki, T., 30/12/2012, In : Statistics in Medicine. 31, 30, p. 4269-4279 11 p.

    Research output: Contribution to journalJournal article

  86. Published

    A novel phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer

    Whitehead, J., Thygesen, H., Jaki, T., Davis, S., Halford, S., Turner, H., Cook, N. & Jodrell, D., 15/08/2012, In : Statistics in Medicine. 31, 18, p. 1931-1943 13 p.

    Research output: Contribution to journalJournal article

  87. Published

    Recovering Independent Associations in Genetics: A Comparison

    Sperrin, M. & Jaki, T., 08/2012, In : Journal of Computational Biology. 19, 8, p. 978–987 10 p.

    Research output: Contribution to journalJournal article

  88. Published

    A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection

    Magirr, D., Jaki, T. & Whitehead, J., 06/2012, In : Biometrika. 99, 2, p. 494-501 8 p.

    Research output: Contribution to journalJournal article

  89. Published

    Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs

    Jaki, T. & Wolfsegger, M. J., 2012, In : Statistics in Medicine. 31, 11-12, p. 1059-1073 25 p.

    Research output: Contribution to journalJournal article

  90. Published

    Not quite normal: Consequences of violating the assumption of normality with regression mixture models

    Van Horn, M. L., Smith, J., Fagan, A., Jaki, T., Maysn, K., Hawkins, D., Feaster, D. & Howe, G., 2012, In : Structural Equation Modeling. 19, 2, p. 227-249 23 p.

    Research output: Contribution to journalJournal article

  91. 2011
  92. Published

    A formal comparison of different methods for establishing cut points to distinguish positive and negative samples in immunoassays.

    Jaki, T., Lawo, J-P., Wolfsegger, M. J., Singer, J., Allacher, P. & Horling, F., 15/07/2011, In : Journal of Pharmaceutical and Biomedical Analysis. 55, 5, p. 1148-1156 9 p.

    Research output: Contribution to journalJournal article

  93. Published

    Estimation of pharmacokinetic parameters with the R package PK.

    Jaki, T. & Wolfsegger, M. J., 05/2011, In : Pharmaceutical Statistics. 10, 2, p. 284-288 5 p.

    Research output: Contribution to journalJournal article

  94. Published

    Symmetric maximum kernel likelihood estimation.

    Jaki, T. & West, R. W., 02/2011, In : Journal of Statistical Computation and Simulation. 81, 2, p. 193-206 14 p.

    Research output: Contribution to journalJournal article

  95. 2010
  96. Published

    Direct effects testing : a two-stage procedure to test for effect size and variable importance for correlated binary predictors and a binary response.

    Sperrin, M. & Jaki, T., 30/10/2010, In : Statistics in Medicine. 29, 24, p. 2544-2556 13 p.

    Research output: Contribution to journalJournal article

  97. Published

    Establishing bioequivalence in complete and incomplete data designs using AUCs.

    Jaki, T., Wolfsegger, M. J. & Lawo, J-P., 07/2010, In : Journal of Biopharmaceutical Statistics. 20, 4, p. 803-820 18 p.

    Research output: Contribution to journalJournal article

  98. Published

    Optimization, refinement and reduction of murine in vivo experiments to assess therapeutic approaches for hemophilia A.

    Baumgartner, B., Jaki, T., Wolfsegger, M. J., Eder, B., Schiviz, A., Schwarz, H. P. & Muchitsch, E. M., 07/2010, In : Laboratory Animals. 44, 3, p. 211-217 7 p.

    Research output: Contribution to journalJournal article

  99. Published

    Probabilistic relabelling strategies for the label switching problem in Bayesian mixture models.

    Sperrin, M., Jaki, T. & Wit, E., 07/2010, In : Statistics and Computing. 20, 3, p. 357-366 10 p.

    Research output: Contribution to journalJournal article

  100. Published

    Book review : Bioequivalence and statistics in clinical pharmacology.

    Jaki, T., 04/2010, In : Journal of the Royal Statistical Society: Series A (Statistics in Society). 173, 2, p. 467-468 2 p.

    Research output: Contribution to journalBook/Film/Article review

  101. 2009
  102. Published

    Assessing systemic drug exposure in repeated dose toxicity studies in the case of complete and incomplete sampling.

    Wolfsegger, M. J. & Jaki, T., 12/2009, In : Biometrical Journal. 51, 6, p. 1017-1026 10 p.

    Research output: Contribution to journalJournal article

  103. Published

    Recording lectures as a service in a service course.

    Jaki, T., 11/2009, In : Journal of Statistics Education. 17, 3

    Research output: Contribution to journalJournal article

  104. Published

    A note on statistical analysis of organ weights in non-clinical toxicological studies.

    Wolfsegger, M. J., Jaki, T., Dietrich, B., Kunzler, J. A. & Barker, K., 10/2009, In : Toxicology and Applied Pharmacology. 240, 1, p. 117-122 6 p.

    Research output: Contribution to journalJournal article

  105. Published

    Non-compartmental estimation of pharmacokinetic parameters in serial sampling designs.

    Wolfsegger, M. J. & Jaki, T., 10/2009, In : Journal of Pharmacokinetics and Pharmacodynamics. 36, 5, p. 479-494

    Research output: Contribution to journalJournal article

  106. Published

    Assessing differential effects: Applying regression mixture models to identify variations in the influence of family resources on academic achievement.

    Van Horn, M. L., Jaki, T., Maysn, K., Ramey, S. L., Smith, J. A. & Antaramian, S., 09/2009, In : Developmental Psychology. 45, 5, p. 1298-1313 16 p.

    Research output: Contribution to journalJournal article

  107. Published

    A theoretical framework for estimation of AUCs in complete and incomplete sampling designs.

    Jaki, T. & Wolfsegger, M. J., 05/2009, In : Statistics in Biopharmaceutical Research. 1, 2, p. 176-184 9 p.

    Research output: Contribution to journalJournal article

  108. Published

    Using a problem-based approach to teach statistics to postgraduate science students : a case study.

    Jaki, T. & Autin, M., 05/2009, In : MSOR Connections. 9, 2, p. 40-47 8 p.

    Research output: Contribution to journalJournal article

  109. Published

    One- and two-stage design proposals for a phase II trial comparing three active treatments with control using an ordered categorical endpoint.

    Whitehead, J. & Jaki, T., 28/02/2009, In : Statistics in Medicine. 28, 5, p. 828-847 20 p.

    Research output: Contribution to journalJournal article

  110. Published

    Confidence Intervals for Ratios of AUC's in the Case of Serial Sampling : A Comparison of Seven Methods.

    Jaki, T., Wolfsegger, M. J. & Ploner, M., 01/2009, In : Pharmaceutical Statistics. 8, 1, p. 12-24 13 p.

    Research output: Contribution to journalJournal article

  111. 2008
  112. Published

    Using Multilevel Mixtures to Evaluate Intervention Effects in Group Randomized Trials.

    Van Horn, M. L., Fagan, A. A., Jaki, T., Brown, E. C., Hawkins, J. D., Arthur, M. W., Abbott, R. D. & Catalano, R. F., 04/2008, In : Multivariate Behavioral Research. 43, 2, p. 289-326 38 p.

    Research output: Contribution to journalJournal article

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