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Distinguishing anhydrous and hydrous forms of an active pharmaceutical ingredient in a tablet formulation using solid-state NMR spectroscopy

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<mark>Journal publication date</mark>22/10/2007
<mark>Journal</mark>Angewandte Chemie International Edition
Issue number42
Volume46
Number of pages3
Pages (from-to)8036-8038
<mark>State</mark>Published
Early online date11/09/07
<mark>Original language</mark>English

Abstract

With or without water? In under two hours, an NMR spectroscopy experiment can determine whether the anhydrous form of an active pharmaceutical ingredient is present in a tablet formulation. Such a high-resolution spectrum constitutes a new analytical tool that should be routinely adopted in the characterization of pharmaceuticals.