Ethnobotanical studies on the displaced indigenous groups of Colombia are scarce. This research report provides a list of 54 plant species (50 genera in 32 families) used by a displaced group of Murui-Muinane (= Witoto, Uitoto, Huitoto) that lives in the city of Florencia, capital of the Department of Caqueta. Only six (11%) plant species are not native to the Americas. Arecaceae and Fabaceae were the families with the highest number of species: eight and six respectively. The three categories of use with the highest number of species were: food (27 spp.), medicinal (15) and handicrafts (15). These 54 plant species used by the Murui in Florencia correspond to 19% of the total number of plants recorded as used by a Murui community that lives in a forested reservation in the Department of Putumayo. Such difference in the number of useful plants is noteworthy given that Colombian indigenous cultures are rapidly transforming and their ethnobotanical knowledge might be lost forever.