Home > Research > Publications & Outputs > Extended neuroleptic administration modulates N...

Research

Associated organisational unit

Electronic data

  • Krzystanek2016Revised

    Rights statement: This is the author’s version of a work that was accepted for publication in Pharmacological Reports. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Pharmacological Reports, 68, 5, 2016 DOI: 10.1016/j.pharep.2016.05.009

    Accepted author manuscript, 264 KB, PDF document

    Available under license: CC BY-NC-ND: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

Links

Text available via DOI:

Keywords

View graph of relations

Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published
  • Marek Krzystanek
  • Katarzyna Bogus
  • Artur Palasz
  • Anna Wiaderkiewicz
  • Lukasz Filipczyk
  • Ewa Rojczyk
  • John Joseph Worthington
  • Ryszard Wiaderkiewicz
Close
More...
<mark>Journal publication date</mark>10/2016
<mark>Journal</mark>Pharmacological reports : PR
Issue number5
Volume68
Number of pages6
Pages (from-to)990-995
Publication StatusPublished
Early online date6/07/16
<mark>Original language</mark>English

Abstract

Background

This study aimed to evaluate the effect of extended olanzapine, clozapine and haloperidol administration on NMDA-R subunit immunoexpression in the rat neocortex and diencephalon.

Methods

To explore NR1, NR2A and NR2B subunit protein expression, densytometric analysis of immunohistochemically stained brain slices was performed.

Results

Interestingly, all neuroleptics caused a downregulation of NMDA-R subunit expression in the thalamus but increased the level of NR1 in the hypothalamus. Olanzapine upregulated hypothalamic NR2A expression, while clozapine and haloperidol decreased hypothalamic levels. We observed no significant changes in NR2B immunoreactivity. None of the studied medications had significant influence on NMDA-R subunit expression in the neocortex.

Conclusions

Neuroleptic-induced reduction in the expression of thalamic NMDA-R subunits may play an important role in the regulation of glutamatergic transmission disorders in cortico–striato–thalamo–cortical loop in schizophrenia. A decrease in NMDA signaling in this region after long-term neuroleptic administration may also cautiously explain the incomplete effectiveness of these drugs in the therapy of schizophrenia-related cognitive disturbances.

Bibliographic note

This is the author’s version of a work that was accepted for publication in Pharmacological Reports. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Pharmacological Reports, 68, 5, 2016 DOI: 10.1016/j.pharep.2016.05.009