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Stage-specific adhesion of Leishmania promastigotes to sand fly midguts assessed using an improved comparative binding assay

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Article numbere816
<mark>Journal publication date</mark>09/2010
<mark>Journal</mark>PLoS Neglected Tropical Diseases
Issue number9
Volume4
Publication statusPublished
Original languageEnglish

Abstract

The binding of Leishmania promastigotes to the midgut epithelium is regarded as an essential part of the life-cycle in the sand fly vector, enabling the parasites to persist beyond the initial blood meal phase and establish the infection. However, the precise nature of the promastigote stage(s) that mediate binding is not fully understood.