We have constructed a large new dilution refrigerator for use with the new Lancaster nuclear cooling facility. The machine is housed in a purpose-rebuilt suite of rooms and has been designed to have a very low base temperature, a very low heat leak environment and to run for long periods between refrigerant refills. The machine has been operated in continuous mode down to similar to 1.75 mK and can run for 10 days between refills. Preliminary nuclear cooling experiments suggest that even with an experiment attached the mixing chamber can still run below 2 mK.