Home > Research > Publications & Outputs > Photochemically controlled drug dosing from a p...

Electronic data

  • PHAM-D-16-00693_accepted_pure

    Rights statement: Copyright of publisher

    Accepted author manuscript, 548 KB, PDF-document

  • 044 - Pharm Res - 2017 - NSAIDS

    Final published version, 581 KB, PDF-document

    Available under license: CC BY: Creative Commons Attribution 4.0 International License

Links

Text available via DOI:

View graph of relations

Photochemically controlled drug dosing from a polymeric scaffold

Research output: Contribution to journalJournal article

Published
  • Louise Donnelly
  • John George Hardy
  • Sean P. Gorman
  • David S. Jones
  • Nicola J. Irwin
  • Colin P. McCoy
Close
<mark>Journal publication date</mark>07/2017
<mark>Journal</mark>Pharmaceutical Research
Issue number7
Volume34
Number of pages8
Pages (from-to)1469-1476
StatePublished
Early online date15/05/17
Original languageEnglish

Abstract

Purpose
To develop the first photoactive biomaterial coating capable of controlled drug dosing via inclusion of synthesised drug-3,5-dimethoxybenzoin (DMB) conjugates in a poly(2-methyoxyethyl acrylate) (pMEA) scaffold.

Methods
Flurbiprofen- and naproxen-DMB conjugates were prepared via esterification and characterised via NMR spectroscopy and mass spectrometry following chromatographic purification. Conjugate photolysis was investigated in acetonitrile solution and within the pMEA matrix following exposure to low-power 365 nm irradiation. Photo-liberation of drug from pMEA into phosphate buffered saline was monitored using UV-vis spectroscopy.

Results
The synthetic procedures yielded the desired drug conjugates with full supporting characterisation. Drug regeneration through photolysis of the synthesised conjugates was successful in both acetonitrile solution and within the pMEA scaffold upon UV irradiation. Conjugates were retained within the pMEA scaffold with exclusive drug liberation following irradiation and increased drug dose with increasing exposure. Multi-dosing capacity was demonstrated though the ability of successive irradiation periods to generate further bursts of drug.

Conclusion
This study demonstrates the first application of photochemically controlled drug release from a biomaterial coating and the feasibility of using pMEA as a scaffold for housing the photoactive drug-DMB conjugates.