Self-assembled PbSe quantum-dots (QD) have been grown on GaSb(100) substrates from the liquid phase. A Pb-rich melt at 517degreesC was used with 10degreesC supercooling and with a short (10 Ins) melt-substrate contact time. Atomic force microscopy has revealed that the PbSe QDs are 4-10 nm in height and 10-40 nm in diameter, with an area density of 1.7 x 10(10) cm(-2). The growth of QDs occurs in the Volmer-Weber mode and is a result of the difference in lattice structures between the PbSe and GaSb rather than the lattice constants.