Abstract Sub-pixel mapping (SPM) is a process for predicting spatially the land cover classes within mixed pixels. In existing SPM methods, the effect of point spread function (PSF) has seldom been considered. In this paper, a generic SPM method is developed to consider the PSF effect in SPM and, thereby, to increase prediction accuracy. We first demonstrate that the spectral unmixing predictions (i.e., coarse land cover proportions used as input for SPM) are a convolution of not only sub-pixels within the coarse pixel, but also sub-pixels from neighboring coarse pixels. Based on this finding, a new SPM method based on optimization is developed which recognizes the optimal solution as the one that when convolved with the PSF, is the same as the input coarse land cover proportion. Experimental results on three separate datasets show that the SPM accuracy can be increased by considering the PSF effect.