Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
| <mark>Journal publication date</mark> | 5/10/2010 |
|---|---|
| <mark>Journal</mark> | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
| Issue number | 7 |
| Volume | 153B |
| Number of pages | 6 |
| Pages (from-to) | 1292-1297 |
| Publication Status | Published |
| Early online date | 27/05/10 |
| <mark>Original language</mark> | English |
We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2 × 10(-5)). Both P-values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.