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3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide.

Research output: Contribution to journalJournal article

Published
  • David Allsop
  • Gillian Gibson
  • Ian K. Martin
  • Susan Moore
  • Stuart Turnbull
  • Lance J. Twyman
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<mark>Journal publication date</mark>01/2001
<mark>Journal</mark>Bioorganic and Medicinal Chemistry Letters
Issue number2
Volume11
Number of pages3
Pages (from-to)255-257
Publication statusPublished
Original languageEnglish

Abstract

The cmc and IC50 values of the β-amyloid (Aβ) aggregation inhibitors, 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran 1, and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran 2 have been determined. After comparison of the cmc data and biological data (IC50 values), we conclude that these active benzofurans do not act as surfactants or micelles at the concentration required to inhibit β-amyloid-peptide aggregation.