Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - A Dependable Microelectronic Peptide Synthesizer Using Electrode Data
AU - Richardson, Andrew
AU - Kerkhoff, H G
AU - Zhang, X.
AU - Mailly, F.
AU - Nouet, P.
AU - Liu, Hongyuan
PY - 2008
Y1 - 2008
N2 - The research in the area of microelectronic fluidic devices for biomedical applications is rapidly growing. As faults in these devices can have serious personal implications, a system is presented which includes fault tolerance with respect to the synthesized biomaterials (peptides). It can employ presence and purity detection of peptide droplets via current (charge) tests of control electrodes or impedance (phase) measurements using direct sensing electrodes near the peptide collector area. The commercial multielectrode array performs better in pure and impure detection of peptides in impedance and phase. Our two-electrode X-MEF case shows slightly poorer results. In both cases the phase is the best choice for contents detection. If there are presence or purity problems, the location is marked, and repeated peptide synthesis at another collector site is initiated.
AB - The research in the area of microelectronic fluidic devices for biomedical applications is rapidly growing. As faults in these devices can have serious personal implications, a system is presented which includes fault tolerance with respect to the synthesized biomaterials (peptides). It can employ presence and purity detection of peptide droplets via current (charge) tests of control electrodes or impedance (phase) measurements using direct sensing electrodes near the peptide collector area. The commercial multielectrode array performs better in pure and impure detection of peptides in impedance and phase. Our two-electrode X-MEF case shows slightly poorer results. In both cases the phase is the best choice for contents detection. If there are presence or purity problems, the location is marked, and repeated peptide synthesis at another collector site is initiated.
U2 - 10.1155/2008/437879
DO - 10.1155/2008/437879
M3 - Journal article
VL - 2008
JO - VLSI Design
JF - VLSI Design
SN - 1065-514X
IS - n/a
M1 - 437879
ER -