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A genome-wide association study of suicide severity scores in bipolar disorder

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A genome-wide association study of suicide severity scores in bipolar disorder. / Zai, Clement C.; Gonçalves, Vanessa F.; Tiwari, Arun K.; Gagliano, Sarah A.; Hosang, Georgina; de Luca, Vincenzo; Shaikh, Sajid A.; King, Nicole; Chen, Qian; Xu, Wei; Strauss, John; Breen, Gerome; Lewis, Cathryn M.; Farmer, Anne E.; McGuffin, Peter; Knight, Jo; Vincent, John B.; Kennedy, James L.

In: Journal of Psychiatric Research, Vol. 65, 06.2015, p. 23-29.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Zai, CC, Gonçalves, VF, Tiwari, AK, Gagliano, SA, Hosang, G, de Luca, V, Shaikh, SA, King, N, Chen, Q, Xu, W, Strauss, J, Breen, G, Lewis, CM, Farmer, AE, McGuffin, P, Knight, J, Vincent, JB & Kennedy, JL 2015, 'A genome-wide association study of suicide severity scores in bipolar disorder', Journal of Psychiatric Research, vol. 65, pp. 23-29. https://doi.org/10.1016/j.jpsychires.2014.11.002

APA

Zai, C. C., Gonçalves, V. F., Tiwari, A. K., Gagliano, S. A., Hosang, G., de Luca, V., Shaikh, S. A., King, N., Chen, Q., Xu, W., Strauss, J., Breen, G., Lewis, C. M., Farmer, A. E., McGuffin, P., Knight, J., Vincent, J. B., & Kennedy, J. L. (2015). A genome-wide association study of suicide severity scores in bipolar disorder. Journal of Psychiatric Research, 65, 23-29. https://doi.org/10.1016/j.jpsychires.2014.11.002

Vancouver

Zai CC, Gonçalves VF, Tiwari AK, Gagliano SA, Hosang G, de Luca V et al. A genome-wide association study of suicide severity scores in bipolar disorder. Journal of Psychiatric Research. 2015 Jun;65:23-29. https://doi.org/10.1016/j.jpsychires.2014.11.002

Author

Zai, Clement C. ; Gonçalves, Vanessa F. ; Tiwari, Arun K. ; Gagliano, Sarah A. ; Hosang, Georgina ; de Luca, Vincenzo ; Shaikh, Sajid A. ; King, Nicole ; Chen, Qian ; Xu, Wei ; Strauss, John ; Breen, Gerome ; Lewis, Cathryn M. ; Farmer, Anne E. ; McGuffin, Peter ; Knight, Jo ; Vincent, John B. ; Kennedy, James L. / A genome-wide association study of suicide severity scores in bipolar disorder. In: Journal of Psychiatric Research. 2015 ; Vol. 65. pp. 23-29.

Bibtex

@article{eec7ae572d7e42abb1db3c1e44460475,
title = "A genome-wide association study of suicide severity scores in bipolar disorder",
abstract = "BACKGROUND: Suicide claims one million lives worldwide annually, making it a serious public health concern. The risk for suicidal behaviour can be partly explained by genetic factors, as suggested by twin and family studies (reviewed in (Zai et al. 2012)). Recently, genome-wide association studies (GWASs) of suicide attempt on large samples of bipolar disorder (BD) patients from multiple sites have identified a number of novel candidate genes. GWASs of suicide behaviour severity, from suicidal ideation to serious suicide attempt, have not been reported for BD.METHODS: We conducted a GWAS of suicide behaviour severity in three independent BD samples:212 small nuclear families with BD probands from Toronto, Canada, 428 BD cases from Toronto, and 483 BD cases from the UK. We carried out imputation with 1000 Genome Project data as reference using IMPUTE2. Quality control and data analysis was conducted using PLINK and R. We conducted the quantitative analyses of suicide behaviour severity in the three samples separately, and derived an overall significance by a meta-analysis using the METAL software.RESULTS: We did not find genome-wide significant association of any tested markers in any of the BD samples, but we found a number of suggestive associations, including regions on chromosomes 8 and 10 (p < 1e-5).CONCLUSIONS: Our GWAS findings suggest that likely many gene variants of small effects contribute collectively to the risk for suicidal behaviour severity in BD. Larger independent replications are required to strengthen the findings from the GWAS presented here.",
keywords = "Bipolar Disorder, Canada, Chromosomes, Human, Pair 10, Chromosomes, Human, Pair 8, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Male, Meta-Analysis as Topic, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Suicide",
author = "Zai, {Clement C.} and Gon{\c c}alves, {Vanessa F.} and Tiwari, {Arun K.} and Gagliano, {Sarah A.} and Georgina Hosang and {de Luca}, Vincenzo and Shaikh, {Sajid A.} and Nicole King and Qian Chen and Wei Xu and John Strauss and Gerome Breen and Lewis, {Cathryn M.} and Farmer, {Anne E.} and Peter McGuffin and Jo Knight and Vincent, {John B.} and Kennedy, {James L.}",
note = "Copyright {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",
year = "2015",
month = jun,
doi = "10.1016/j.jpsychires.2014.11.002",
language = "English",
volume = "65",
pages = "23--29",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - A genome-wide association study of suicide severity scores in bipolar disorder

AU - Zai, Clement C.

AU - Gonçalves, Vanessa F.

AU - Tiwari, Arun K.

AU - Gagliano, Sarah A.

AU - Hosang, Georgina

AU - de Luca, Vincenzo

AU - Shaikh, Sajid A.

AU - King, Nicole

AU - Chen, Qian

AU - Xu, Wei

AU - Strauss, John

AU - Breen, Gerome

AU - Lewis, Cathryn M.

AU - Farmer, Anne E.

AU - McGuffin, Peter

AU - Knight, Jo

AU - Vincent, John B.

AU - Kennedy, James L.

N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

PY - 2015/6

Y1 - 2015/6

N2 - BACKGROUND: Suicide claims one million lives worldwide annually, making it a serious public health concern. The risk for suicidal behaviour can be partly explained by genetic factors, as suggested by twin and family studies (reviewed in (Zai et al. 2012)). Recently, genome-wide association studies (GWASs) of suicide attempt on large samples of bipolar disorder (BD) patients from multiple sites have identified a number of novel candidate genes. GWASs of suicide behaviour severity, from suicidal ideation to serious suicide attempt, have not been reported for BD.METHODS: We conducted a GWAS of suicide behaviour severity in three independent BD samples:212 small nuclear families with BD probands from Toronto, Canada, 428 BD cases from Toronto, and 483 BD cases from the UK. We carried out imputation with 1000 Genome Project data as reference using IMPUTE2. Quality control and data analysis was conducted using PLINK and R. We conducted the quantitative analyses of suicide behaviour severity in the three samples separately, and derived an overall significance by a meta-analysis using the METAL software.RESULTS: We did not find genome-wide significant association of any tested markers in any of the BD samples, but we found a number of suggestive associations, including regions on chromosomes 8 and 10 (p < 1e-5).CONCLUSIONS: Our GWAS findings suggest that likely many gene variants of small effects contribute collectively to the risk for suicidal behaviour severity in BD. Larger independent replications are required to strengthen the findings from the GWAS presented here.

AB - BACKGROUND: Suicide claims one million lives worldwide annually, making it a serious public health concern. The risk for suicidal behaviour can be partly explained by genetic factors, as suggested by twin and family studies (reviewed in (Zai et al. 2012)). Recently, genome-wide association studies (GWASs) of suicide attempt on large samples of bipolar disorder (BD) patients from multiple sites have identified a number of novel candidate genes. GWASs of suicide behaviour severity, from suicidal ideation to serious suicide attempt, have not been reported for BD.METHODS: We conducted a GWAS of suicide behaviour severity in three independent BD samples:212 small nuclear families with BD probands from Toronto, Canada, 428 BD cases from Toronto, and 483 BD cases from the UK. We carried out imputation with 1000 Genome Project data as reference using IMPUTE2. Quality control and data analysis was conducted using PLINK and R. We conducted the quantitative analyses of suicide behaviour severity in the three samples separately, and derived an overall significance by a meta-analysis using the METAL software.RESULTS: We did not find genome-wide significant association of any tested markers in any of the BD samples, but we found a number of suggestive associations, including regions on chromosomes 8 and 10 (p < 1e-5).CONCLUSIONS: Our GWAS findings suggest that likely many gene variants of small effects contribute collectively to the risk for suicidal behaviour severity in BD. Larger independent replications are required to strengthen the findings from the GWAS presented here.

KW - Bipolar Disorder

KW - Canada

KW - Chromosomes, Human, Pair 10

KW - Chromosomes, Human, Pair 8

KW - Female

KW - Genetic Association Studies

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Male

KW - Meta-Analysis as Topic

KW - Oligonucleotide Array Sequence Analysis

KW - Polymorphism, Single Nucleotide

KW - Suicide

U2 - 10.1016/j.jpsychires.2014.11.002

DO - 10.1016/j.jpsychires.2014.11.002

M3 - Journal article

C2 - 25917933

VL - 65

SP - 23

EP - 29

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

ER -