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  • 1-s2.0-S0040402018302126-main

    Rights statement: This is the author’s version of a work that was accepted for publication in Tetrahedron. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron, 74, 15, 2018 DOI: 10.1016/j.tet.2018.02.054

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    Embargo ends: 27/02/19

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A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: Selective synthesis of substituted 5-aza-9-deaza-adenines1

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<mark>Journal publication date</mark>12/04/2018
<mark>Journal</mark>Tetrahedron
Issue number15
Volume74
Number of pages12
Pages (from-to)1868-1879
<mark>State</mark>Published
Early online date27/02/18
<mark>Original language</mark>English

Abstract

A series of 5-aza-9-deaza- analogues of purine was effectively prepared using highly selective annulation of 1,3,5-triazine ring onto 5-aminopyrazole-4-carboxylates via a one-pot, multicomponent, microwave-assisted approach. The products were obtained in good yields and high purity. This catalyst-free method was demonstrated to be scalable and highly reproducible in different microwave reactors. Some structural features of the prepared compounds were studied in details using dynamic NMR spectroscopy and X-ray crystallography.

Bibliographic note

This is the author’s version of a work that was accepted for publication in Tetrahedron. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron, 74, 15, 2018 DOI: 10.1016/j.tet.2018.02.054