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  • Geisa_Salles_Paper1_2016_Rev_16

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A novel bioresorbable device as a controlled release system for protecting cells from oxidative stress from Alzheimer’s Disease

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A novel bioresorbable device as a controlled release system for protecting cells from oxidative stress from Alzheimer’s Disease. / Salles, Geisa Nogueira; Pereira, Fernanda Aparecida dos Santos; Pacheco-Soares, Cristina et al.
In: Molecular Neurobiology, Vol. 54, No. 9, 11.2017, p. 6827-6838.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Salles, GN, Pereira, FADS, Pacheco-Soares, C, Marciano, FR, Holscher, C, Webster, TJ & Lobo, AO 2017, 'A novel bioresorbable device as a controlled release system for protecting cells from oxidative stress from Alzheimer’s Disease', Molecular Neurobiology, vol. 54, no. 9, pp. 6827-6838. https://doi.org/10.1007/s12035-016-0200-0

APA

Salles, G. N., Pereira, F. A. D. S., Pacheco-Soares, C., Marciano, F. R., Holscher, C., Webster, T. J., & Lobo, A. O. (2017). A novel bioresorbable device as a controlled release system for protecting cells from oxidative stress from Alzheimer’s Disease. Molecular Neurobiology, 54(9), 6827-6838. https://doi.org/10.1007/s12035-016-0200-0

Vancouver

Salles GN, Pereira FADS, Pacheco-Soares C, Marciano FR, Holscher C, Webster TJ et al. A novel bioresorbable device as a controlled release system for protecting cells from oxidative stress from Alzheimer’s Disease. Molecular Neurobiology. 2017 Nov;54(9):6827-6838. Epub 2016 Oct 20. doi: 10.1007/s12035-016-0200-0

Author

Salles, Geisa Nogueira ; Pereira, Fernanda Aparecida dos Santos ; Pacheco-Soares, Cristina et al. / A novel bioresorbable device as a controlled release system for protecting cells from oxidative stress from Alzheimer’s Disease. In: Molecular Neurobiology. 2017 ; Vol. 54, No. 9. pp. 6827-6838.

Bibtex

@article{e97d0be2629a4036bf3cf7b8a0ff73b2,
title = "A novel bioresorbable device as a controlled release system for protecting cells from oxidative stress from Alzheimer{\textquoteright}s Disease",
abstract = "Bioresorbable electrospun fibres have highly functional features that can preserve drug efficacy, avoiding premature degradation, and control drug release rates over long periods. In parallel, it is known that Alzheimer{\textquoteright}s disease (AD) has been linked to impaired insulin signalling in the brain. Glucagon-like peptide 1 (GLP-1) analogues have beneficial effects on insulin release and possess exceptional neuroprotective properties. Herein, we describe for the first time the incorporation of a GLP-1 analogue, liraglutide, into electrospun poly (lactic acid) (PLA) fibres with in situ gelatin capsules, in order to provide the controlled release of liraglutide, improving neuroprotective properties. In this study, PLA, a bioresorbable polymer in which degradation products have neurogenesis characteristics, was electrospun and loaded with liraglutide. Moreover, PLA/liraglutide fibres were encapsulated with gelatin and were shown to have better properties than the non-encapsulated fibres in terms of the controlled release of liraglutide, which was accomplished in the present study for up to 60 days. We observed that this biodevice was completely encapsulated with gelatin, which made the material more hydrophilic than PLA fibres alone and the biodevice was able to enhance fibroblast interaction and reduce mitochondrial stress in a neuroblastoma cell line. In this manner, this study introduces a new material which can improve neuroprotective properties from AD oxidative stress via the sustained long-lasting release of liraglutide.",
keywords = "Electrospun fibres, Polyester , Drug delivery, Sustained release, Liraglutide , Alzheimer{\textquoteright}s disease, Biodevice",
author = "Salles, {Geisa Nogueira} and Pereira, {Fernanda Aparecida dos Santos} and Cristina Pacheco-Soares and Marciano, {Fernanda Roberta} and Christian Holscher and Webster, {Thomas J.} and Lobo, {Anderson Oliveira}",
note = "The final publication is available at Springer via http://dx.doi.org/10.1007/s12035-016-0200-0",
year = "2017",
month = nov,
doi = "10.1007/s12035-016-0200-0",
language = "English",
volume = "54",
pages = "6827--6838",
journal = "Molecular Neurobiology",
issn = "0893-7648",
publisher = "Humana Press",
number = "9",

}

RIS

TY - JOUR

T1 - A novel bioresorbable device as a controlled release system for protecting cells from oxidative stress from Alzheimer’s Disease

AU - Salles, Geisa Nogueira

AU - Pereira, Fernanda Aparecida dos Santos

AU - Pacheco-Soares, Cristina

AU - Marciano, Fernanda Roberta

AU - Holscher, Christian

AU - Webster, Thomas J.

AU - Lobo, Anderson Oliveira

N1 - The final publication is available at Springer via http://dx.doi.org/10.1007/s12035-016-0200-0

PY - 2017/11

Y1 - 2017/11

N2 - Bioresorbable electrospun fibres have highly functional features that can preserve drug efficacy, avoiding premature degradation, and control drug release rates over long periods. In parallel, it is known that Alzheimer’s disease (AD) has been linked to impaired insulin signalling in the brain. Glucagon-like peptide 1 (GLP-1) analogues have beneficial effects on insulin release and possess exceptional neuroprotective properties. Herein, we describe for the first time the incorporation of a GLP-1 analogue, liraglutide, into electrospun poly (lactic acid) (PLA) fibres with in situ gelatin capsules, in order to provide the controlled release of liraglutide, improving neuroprotective properties. In this study, PLA, a bioresorbable polymer in which degradation products have neurogenesis characteristics, was electrospun and loaded with liraglutide. Moreover, PLA/liraglutide fibres were encapsulated with gelatin and were shown to have better properties than the non-encapsulated fibres in terms of the controlled release of liraglutide, which was accomplished in the present study for up to 60 days. We observed that this biodevice was completely encapsulated with gelatin, which made the material more hydrophilic than PLA fibres alone and the biodevice was able to enhance fibroblast interaction and reduce mitochondrial stress in a neuroblastoma cell line. In this manner, this study introduces a new material which can improve neuroprotective properties from AD oxidative stress via the sustained long-lasting release of liraglutide.

AB - Bioresorbable electrospun fibres have highly functional features that can preserve drug efficacy, avoiding premature degradation, and control drug release rates over long periods. In parallel, it is known that Alzheimer’s disease (AD) has been linked to impaired insulin signalling in the brain. Glucagon-like peptide 1 (GLP-1) analogues have beneficial effects on insulin release and possess exceptional neuroprotective properties. Herein, we describe for the first time the incorporation of a GLP-1 analogue, liraglutide, into electrospun poly (lactic acid) (PLA) fibres with in situ gelatin capsules, in order to provide the controlled release of liraglutide, improving neuroprotective properties. In this study, PLA, a bioresorbable polymer in which degradation products have neurogenesis characteristics, was electrospun and loaded with liraglutide. Moreover, PLA/liraglutide fibres were encapsulated with gelatin and were shown to have better properties than the non-encapsulated fibres in terms of the controlled release of liraglutide, which was accomplished in the present study for up to 60 days. We observed that this biodevice was completely encapsulated with gelatin, which made the material more hydrophilic than PLA fibres alone and the biodevice was able to enhance fibroblast interaction and reduce mitochondrial stress in a neuroblastoma cell line. In this manner, this study introduces a new material which can improve neuroprotective properties from AD oxidative stress via the sustained long-lasting release of liraglutide.

KW - Electrospun fibres

KW - Polyester

KW - Drug delivery

KW - Sustained release

KW - Liraglutide

KW - Alzheimer’s disease

KW - Biodevice

U2 - 10.1007/s12035-016-0200-0

DO - 10.1007/s12035-016-0200-0

M3 - Journal article

VL - 54

SP - 6827

EP - 6838

JO - Molecular Neurobiology

JF - Molecular Neurobiology

SN - 0893-7648

IS - 9

ER -