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A novel method with improved power to detect recombination hotspots from polymorphism data reveals multiple hotspots in human genes.

Research output: Contribution to journalJournal article

Published

Journal publication date2005
JournalAmerican Journal of Human Genetics
Journal number5
Volume77
Number of pages14
Pages781-794
Original languageEnglish

Abstract

We introduce a new method for detection of recombination hotspots from population genetic data. This method is based on (a) defining an (approximate) penalized likelihood for how recombination rate varies with physical position and (b) maximizing this penalized likelihood over possible sets of recombination hotspots. Simulation results suggest that this is a more powerful method for detection of hotspots than are existing methods. We apply the method to data from 89 genes sequenced in African American and European American populations. We find many genes with multiple hotspots, and some hotspots show evidence of being population-specific. Our results suggest that hotspots are randomly positioned within genes and could be as frequent as one per 30 kb.