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A ‘Sleeping Trojan Horse’ which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging

Research output: Contribution to journalJournal article

Published

  • Flora L. Thorp-Greenwood
  • Vanesa Fernandez-Moreira
  • Coralie Millet
  • Catrin F. Williams
  • Joanne Cable
  • Jonathan B. Court
  • Anthony J. Hayes
  • David Lloyd
  • Michael Coogan
Journal publication date2011
JournalChemical Communications
Journal number11
Volume47
Number of pages3
Pages3096-3098
Original languageEnglish

Abstract

A rhenium polypyridine-based molecular vessel is membrane impermeant when empty, but, upon loading with metal ions, the cationic form is taken up by MCF-7 cells, localising in nucleoli. The luminescence of the vessel and its copper binding ability suggest potential as a bimodal fluorescence/PET imaging agent.