TY - JOUR

T1 - A study of the effect of precursors on physical and biological properties of mesoporous bioactive glass

AU - Shah, A.T.

AU - Ain, Q.

AU - Chaudhry, A.A.

AU - Khan, A.F.

AU - Iqbal, B.

AU - Ahmad, S.

AU - Siddiqi, S.A.

AU - Rehman, I.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - A novel mesoporous bioactive glass (MBG) of composition 64SiO 2 –26CaO–10P 2 O 5 (mol %) was prepared by hydrothermal method using H 3 PO 4 as a precursor for P 2 O 5 . The effect of use of organic triethylphosphate (TEP) and inorganic H 3 PO 4 in MBG synthesis on glass transition temperature (T g ), crystallinity, morphology and bioactivity of MBGs was studied. Phase purity determination and structural analysis were done using powder X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy, respectively. XRD revealed that MBG prepared from H 3 PO 4 (MBG-H 3 PO 4 ) when sintered at 700 °C was partially glassy/amorphous in nature and contained a mixture of crystalline apatite, wollastonite, calcium phosphate and calcium silicate phases. Calcined MBG prepared from TEP (MBG-TEP) contained only wollastonite and calcium silicate phases. Particle size and surface area determined by BET surface area analysis showed higher surface area (310 m 2  g −1 ) for MBG-H 3 PO 4 as compared to MBG-TEP (86 m 2  g −1 ). It also had a smaller particle size (20 nm) and 70 % higher pore volume (0.88 cm 3  g −1 ) for MBG-H 3 PO 4 as compared to MBG-TEP (60 nm particle size and 0.23 cm 3  g −1 pore volume). Thermal studies showed that use of H 3 PO 4 decreases T g and increased ΔT (difference between T g and crystallization initiation temperature Tc o ). Low T g and high ΔT also enhanced bioactivity of MBGs. Bioactivity was determined by immersion in a simulated body fluid for varying time intervals for a maximum period of 14 days. It revealed enhanced bioactivity, as evident by the formation of apatite layer on the surface, for MBG-H 3 PO 4 as compared to MBG-TEP. Scanning electron microscopy and FTIR spectroscopy also supported this observation. Antibacterial studies with Escherichia Coli bacteria, MBG-H 3 PO 4 showed better antibacterial behaviour than MBG-TEP. © 2014, Springer Science+Business Media New York.

AB - A novel mesoporous bioactive glass (MBG) of composition 64SiO 2 –26CaO–10P 2 O 5 (mol %) was prepared by hydrothermal method using H 3 PO 4 as a precursor for P 2 O 5 . The effect of use of organic triethylphosphate (TEP) and inorganic H 3 PO 4 in MBG synthesis on glass transition temperature (T g ), crystallinity, morphology and bioactivity of MBGs was studied. Phase purity determination and structural analysis were done using powder X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy, respectively. XRD revealed that MBG prepared from H 3 PO 4 (MBG-H 3 PO 4 ) when sintered at 700 °C was partially glassy/amorphous in nature and contained a mixture of crystalline apatite, wollastonite, calcium phosphate and calcium silicate phases. Calcined MBG prepared from TEP (MBG-TEP) contained only wollastonite and calcium silicate phases. Particle size and surface area determined by BET surface area analysis showed higher surface area (310 m 2  g −1 ) for MBG-H 3 PO 4 as compared to MBG-TEP (86 m 2  g −1 ). It also had a smaller particle size (20 nm) and 70 % higher pore volume (0.88 cm 3  g −1 ) for MBG-H 3 PO 4 as compared to MBG-TEP (60 nm particle size and 0.23 cm 3  g −1 pore volume). Thermal studies showed that use of H 3 PO 4 decreases T g and increased ΔT (difference between T g and crystallization initiation temperature Tc o ). Low T g and high ΔT also enhanced bioactivity of MBGs. Bioactivity was determined by immersion in a simulated body fluid for varying time intervals for a maximum period of 14 days. It revealed enhanced bioactivity, as evident by the formation of apatite layer on the surface, for MBG-H 3 PO 4 as compared to MBG-TEP. Scanning electron microscopy and FTIR spectroscopy also supported this observation. Antibacterial studies with Escherichia Coli bacteria, MBG-H 3 PO 4 showed better antibacterial behaviour than MBG-TEP. © 2014, Springer Science+Business Media New York.

KW - Apatite

KW - Bioactivity

KW - Calcium

KW - Calcium silicate

KW - Escherichia coli

KW - Fourier transform infrared spectroscopy

KW - Glass transition

KW - Particle size

KW - Particle size analysis

KW - Scanning electron microscopy

KW - Silicate minerals

KW - Sintering

KW - X ray diffraction

KW - Anti-bacterial studies

KW - Biological properties

KW - Escherichia coli bacteria

KW - Initiation temperature

KW - Mesoporous bioactive glass

KW - Particle size and surfaces

KW - Powder X ray diffraction

KW - Simulated body fluids

KW - Bioactive glass

U2 - 10.1007/s10853-014-8742-x

DO - 10.1007/s10853-014-8742-x

M3 - Journal article

VL - 50

SP - 1794

EP - 1804

JO - Journal of Materials Science

JF - Journal of Materials Science

SN - 0022-2461

IS - 4

ER -