Final published version
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - A wish list for synthetic biology in photosynthesis research
AU - Zhu, X.-G.
AU - Ort, D.R.
AU - Parry, M.A.J.
AU - Von Caemmerer, S.
PY - 2020/4/6
Y1 - 2020/4/6
N2 - This perspective summarizes the presentations and discussions at the "International Symposium on Synthetic Biology in Photosynthesis Research", which was held in Shanghai in 2018. Leveraging the current advanced understanding of photosynthetic systems, the symposium brain-stormed about the redesign and engineering of photosynthetic systems for translational goals and evaluated available new technologies/tools for synthetic biology as well as technological obstacles and new tools that would be needed to overcome them. Four major research areas for redesigning photosynthesis were identified: (i) mining natural variations of photosynthesis; (ii) coordinating photosynthesis with pathways utilizing photosynthate; (iii) reconstruction of highly efficient photosynthetic systems in non-host species; and (iv) development of new photosynthetic systems that do not exist in nature. To expedite photosynthesis synthetic biology research, an array of new technologies and community resources need to be developed, which include expanded modelling capacities, molecular engineering toolboxes, model species, and phenotyping tools. © 2020 The Author(s).
AB - This perspective summarizes the presentations and discussions at the "International Symposium on Synthetic Biology in Photosynthesis Research", which was held in Shanghai in 2018. Leveraging the current advanced understanding of photosynthetic systems, the symposium brain-stormed about the redesign and engineering of photosynthetic systems for translational goals and evaluated available new technologies/tools for synthetic biology as well as technological obstacles and new tools that would be needed to overcome them. Four major research areas for redesigning photosynthesis were identified: (i) mining natural variations of photosynthesis; (ii) coordinating photosynthesis with pathways utilizing photosynthate; (iii) reconstruction of highly efficient photosynthetic systems in non-host species; and (iv) development of new photosynthetic systems that do not exist in nature. To expedite photosynthesis synthetic biology research, an array of new technologies and community resources need to be developed, which include expanded modelling capacities, molecular engineering toolboxes, model species, and phenotyping tools. © 2020 The Author(s).
KW - Artificial photosynthesis
KW - C4 engineering
KW - carboxysome
KW - fluorescence marker proteins
KW - natural variation
KW - photosynthesis
KW - synthetic biology
U2 - 10.1093/jxb/eraa075
DO - 10.1093/jxb/eraa075
M3 - Journal article
VL - 71
SP - 2219
EP - 2225
JO - Journal of Experimental Botany
JF - Journal of Experimental Botany
SN - 0022-0957
IS - 7
ER -