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Abnormalities of saccadic eye movements in dementia due to Alzheimer's disease and mild cognitive impairment

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@article{388750bdaca24bd4958646662fb81fb3,
title = "Abnormalities of saccadic eye movements in dementia due to Alzheimer's disease and mild cognitive impairment",
abstract = "Background: There is increasing evidence that people in the early stages of Alzheimer{\textquoteright}s disease (AD) have subtle impairments in cognitive inhibition that can be detected by using relatively simple eye-tracking paradigms, but these subtle impairments are often missed by traditional cognitive assessments. People with mild cognitive impairment (MCI) are at an increased likelihood of dementia due to AD. No study has yet investigated and contrasted the MCI subtypes in relation to eye movement performance. Methods: In this work we explore whether eye-tracking impairments can distinguish between patients with the amnesic and the non-amnesic variants of MCI. Participants were 68 people with dementia due to AD, 42 had a diagnosis of aMCI, and 47 had a diagnosis of naMCI, and 92 age-matched cognitively healthy controls. Results: The findings revealed that eye-tracking can distinguish between the two forms of MCI. Conclusions: The work provides further support for eye-tracking as a useful diagnostic biomarker in the assessment of dementia.",
keywords = "mild cognitive impairment, Alzheimer{\textquoteright}s disease, inhibitory control, eye tracking, anti-saccade",
author = "Thomas Wilcockson and Diako Mardanbegi and Baiqiang Xia and Simon Taylor and Pete Sawyer and Hans Gellersen and Ira Leroi and Rebecca Killick and Trevor Crawford",
year = "2019",
month = aug
day = "15",
doi = "10.18632/aging.102118",
language = "English",
volume = "11",
pages = "5389--5398",
journal = "Aging",
issn = "1945-4589",
publisher = "Impact Journals LLC",
number = "15",

}

RIS

TY - JOUR

T1 - Abnormalities of saccadic eye movements in dementia due to Alzheimer's disease and mild cognitive impairment

AU - Wilcockson, Thomas

AU - Mardanbegi, Diako

AU - Xia, Baiqiang

AU - Taylor, Simon

AU - Sawyer, Pete

AU - Gellersen, Hans

AU - Leroi, Ira

AU - Killick, Rebecca

AU - Crawford, Trevor

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Background: There is increasing evidence that people in the early stages of Alzheimer’s disease (AD) have subtle impairments in cognitive inhibition that can be detected by using relatively simple eye-tracking paradigms, but these subtle impairments are often missed by traditional cognitive assessments. People with mild cognitive impairment (MCI) are at an increased likelihood of dementia due to AD. No study has yet investigated and contrasted the MCI subtypes in relation to eye movement performance. Methods: In this work we explore whether eye-tracking impairments can distinguish between patients with the amnesic and the non-amnesic variants of MCI. Participants were 68 people with dementia due to AD, 42 had a diagnosis of aMCI, and 47 had a diagnosis of naMCI, and 92 age-matched cognitively healthy controls. Results: The findings revealed that eye-tracking can distinguish between the two forms of MCI. Conclusions: The work provides further support for eye-tracking as a useful diagnostic biomarker in the assessment of dementia.

AB - Background: There is increasing evidence that people in the early stages of Alzheimer’s disease (AD) have subtle impairments in cognitive inhibition that can be detected by using relatively simple eye-tracking paradigms, but these subtle impairments are often missed by traditional cognitive assessments. People with mild cognitive impairment (MCI) are at an increased likelihood of dementia due to AD. No study has yet investigated and contrasted the MCI subtypes in relation to eye movement performance. Methods: In this work we explore whether eye-tracking impairments can distinguish between patients with the amnesic and the non-amnesic variants of MCI. Participants were 68 people with dementia due to AD, 42 had a diagnosis of aMCI, and 47 had a diagnosis of naMCI, and 92 age-matched cognitively healthy controls. Results: The findings revealed that eye-tracking can distinguish between the two forms of MCI. Conclusions: The work provides further support for eye-tracking as a useful diagnostic biomarker in the assessment of dementia.

KW - mild cognitive impairment

KW - Alzheimer’s disease

KW - inhibitory control

KW - eye tracking

KW - anti-saccade

U2 - 10.18632/aging.102118

DO - 10.18632/aging.102118

M3 - Journal article

VL - 11

SP - 5389

EP - 5398

JO - Aging

JF - Aging

SN - 1945-4589

IS - 15

ER -