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Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

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Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet. / Gault, V. A.; Porter, W. D.; Flatt, P. R. et al.
In: International Journal of Obesity, Vol. 34, 08.2010, p. 1341-1344.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Gault, VA, Porter, WD, Flatt, PR & Holscher, C 2010, 'Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet', International Journal of Obesity, vol. 34, pp. 1341-1344. https://doi.org/10.1038/ijo.2010.59

APA

Gault, V. A., Porter, W. D., Flatt, P. R., & Holscher, C. (2010). Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet. International Journal of Obesity, 34, 1341-1344. https://doi.org/10.1038/ijo.2010.59

Vancouver

Gault VA, Porter WD, Flatt PR, Holscher C. Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet. International Journal of Obesity. 2010 Aug;34:1341-1344. doi: 10.1038/ijo.2010.59

Author

Gault, V. A. ; Porter, W. D. ; Flatt, P. R. et al. / Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet. In: International Journal of Obesity. 2010 ; Vol. 34. pp. 1341-1344.

Bibtex

@article{090a8e57f8e14d428b0933282453f218,
title = "Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet",
abstract = "High-calorie diet has been shown to impair learning ability and hippocampal synaptic plasticity in rodents. This study examined effects of daily treatment with the glucagon-like peptide-1 mimetic, exendin-4, on cognitive function and hippocampal synaptic plasticity in a model of diet-induced obesity, which exhibits compromised cognitive performance. Mice fed a high-fat diet were treated with exendin-4 (25 nmol kg−1 bodyweight; twice daily) or saline vehicle (0.9% (w/v) NaCl) over 21 days. In addition to improving metabolic control, exendin-4-treated mice exhibited a marked increase in recognition index highlighting improved learning and memory. High-fat diet resulted in the elimination of in vivo electrophysiological long-term potentiation, which was rescued following exendin-4 treatment. This study shows that exendin-4 therapy improves cognitive function and ameliorates impaired hippocampal synaptic plasticity in dietary-induced obesity.",
author = "Gault, {V. A.} and Porter, {W. D.} and Flatt, {P. R.} and Christian Holscher",
year = "2010",
month = aug,
doi = "10.1038/ijo.2010.59",
language = "English",
volume = "34",
pages = "1341--1344",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

AU - Gault, V. A.

AU - Porter, W. D.

AU - Flatt, P. R.

AU - Holscher, Christian

PY - 2010/8

Y1 - 2010/8

N2 - High-calorie diet has been shown to impair learning ability and hippocampal synaptic plasticity in rodents. This study examined effects of daily treatment with the glucagon-like peptide-1 mimetic, exendin-4, on cognitive function and hippocampal synaptic plasticity in a model of diet-induced obesity, which exhibits compromised cognitive performance. Mice fed a high-fat diet were treated with exendin-4 (25 nmol kg−1 bodyweight; twice daily) or saline vehicle (0.9% (w/v) NaCl) over 21 days. In addition to improving metabolic control, exendin-4-treated mice exhibited a marked increase in recognition index highlighting improved learning and memory. High-fat diet resulted in the elimination of in vivo electrophysiological long-term potentiation, which was rescued following exendin-4 treatment. This study shows that exendin-4 therapy improves cognitive function and ameliorates impaired hippocampal synaptic plasticity in dietary-induced obesity.

AB - High-calorie diet has been shown to impair learning ability and hippocampal synaptic plasticity in rodents. This study examined effects of daily treatment with the glucagon-like peptide-1 mimetic, exendin-4, on cognitive function and hippocampal synaptic plasticity in a model of diet-induced obesity, which exhibits compromised cognitive performance. Mice fed a high-fat diet were treated with exendin-4 (25 nmol kg−1 bodyweight; twice daily) or saline vehicle (0.9% (w/v) NaCl) over 21 days. In addition to improving metabolic control, exendin-4-treated mice exhibited a marked increase in recognition index highlighting improved learning and memory. High-fat diet resulted in the elimination of in vivo electrophysiological long-term potentiation, which was rescued following exendin-4 treatment. This study shows that exendin-4 therapy improves cognitive function and ameliorates impaired hippocampal synaptic plasticity in dietary-induced obesity.

UR - http://www.scopus.com/inward/record.url?scp=77955470617&partnerID=8YFLogxK

U2 - 10.1038/ijo.2010.59

DO - 10.1038/ijo.2010.59

M3 - Journal article

AN - SCOPUS:77955470617

VL - 34

SP - 1341

EP - 1344

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -