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Age-associated changes of brain copper, iron, and zinc in Alzheimer's disease and dementia with Lewy bodies

Research output: Contribution to journalJournal article

Published
  • Stewart F. Graham
  • Muhammad Bin Nasaruddin
  • Manus Carey
  • Christian Holscher
  • Bernadette McGuinness
  • Patrick G. Kehoe
  • Seth Love
  • Peter Passmore
  • Christopher T. Elliott
  • Andrew A. Meharg
  • Brian D. Green
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<mark>Journal publication date</mark>2014
<mark>Journal</mark>Journal of Alzheimer's Disease
Issue number4
Volume42
Number of pages7
Pages (from-to)1407-1413
Publication statusPublished
Early online date11/07/14
Original languageEnglish

Abstract

Disease-, age-, and gender-associated changes in brain copper, iron, and zinc were assessed in postmortem neocortical tissue (Brodmann area 7) from patients with moderate Alzheimer's disease (AD) (n = 14), severe AD (n = 28), dementia with Lewy bodies (n = 15), and normal age-matched control subjects (n = 26). Copper was lower (20%; p