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Amyloid deposition as the central event in the aetiology of Alzheimer's disease

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Amyloid deposition as the central event in the aetiology of Alzheimer's disease. / Hardy, J; Allsop, D.
In: Trends in Pharmacological Sciences, Vol. 12, No. 10, 1991, p. 383-388.

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Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends in Pharmacological Sciences. 1991;12(10):383-388. doi: 10.1016/0165-6147(91)90609-V

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Hardy, J ; Allsop, D. / Amyloid deposition as the central event in the aetiology of Alzheimer's disease. In: Trends in Pharmacological Sciences. 1991 ; Vol. 12, No. 10. pp. 383-388.

Bibtex

@article{e66177b18bb845a49c95b7ec851fbf0e,
title = "Amyloid deposition as the central event in the aetiology of Alzheimer's disease",
abstract = "While there may be many causes of Alzheimer's disease (AD), the same pathological sequence of events, described here by John Hardy and David Allsop, is likely to occur in all cases. The recent discovery of a pathogenic mutation in the beta-amyloid precursor protein (APP) gene on chromosome 21 suggests that APP Mismetabolism and beta-amyloid deposition are the primary events in the disease process. The occurrence of AD in Down syndrome is consistent with this hypothesis. The pathological cascade for the disease process is most likely to be: beta-amyloid deposition----tau phosphorylation and tangle formation----neuronal death. The development of a biochemical understanding of this pathological cascade will facilitate rational design of drugs to intervene in this process.",
keywords = "Alzheimer Disease, Amyloid, Amyloid beta-Protein Precursor, Animals, Cell Death, Humans, Neurofibrillary Tangles",
author = "J Hardy and D Allsop",
year = "1991",
doi = "10.1016/0165-6147(91)90609-V",
language = "English",
volume = "12",
pages = "383--388",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier Limited",
number = "10",

}

RIS

TY - JOUR

T1 - Amyloid deposition as the central event in the aetiology of Alzheimer's disease

AU - Hardy, J

AU - Allsop, D

PY - 1991

Y1 - 1991

N2 - While there may be many causes of Alzheimer's disease (AD), the same pathological sequence of events, described here by John Hardy and David Allsop, is likely to occur in all cases. The recent discovery of a pathogenic mutation in the beta-amyloid precursor protein (APP) gene on chromosome 21 suggests that APP Mismetabolism and beta-amyloid deposition are the primary events in the disease process. The occurrence of AD in Down syndrome is consistent with this hypothesis. The pathological cascade for the disease process is most likely to be: beta-amyloid deposition----tau phosphorylation and tangle formation----neuronal death. The development of a biochemical understanding of this pathological cascade will facilitate rational design of drugs to intervene in this process.

AB - While there may be many causes of Alzheimer's disease (AD), the same pathological sequence of events, described here by John Hardy and David Allsop, is likely to occur in all cases. The recent discovery of a pathogenic mutation in the beta-amyloid precursor protein (APP) gene on chromosome 21 suggests that APP Mismetabolism and beta-amyloid deposition are the primary events in the disease process. The occurrence of AD in Down syndrome is consistent with this hypothesis. The pathological cascade for the disease process is most likely to be: beta-amyloid deposition----tau phosphorylation and tangle formation----neuronal death. The development of a biochemical understanding of this pathological cascade will facilitate rational design of drugs to intervene in this process.

KW - Alzheimer Disease

KW - Amyloid

KW - Amyloid beta-Protein Precursor

KW - Animals

KW - Cell Death

KW - Humans

KW - Neurofibrillary Tangles

U2 - 10.1016/0165-6147(91)90609-V

DO - 10.1016/0165-6147(91)90609-V

M3 - Journal article

C2 - 1763432

VL - 12

SP - 383

EP - 388

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

IS - 10

ER -