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  • Trans R Soc Trop Med Hyg - Nov 17 2016 - An extensive burden of giardiasis

    Rights statement: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Transactions of the Royal Society of Tropical Medicine and Hygiene following peer review. The definitive publisher-authenticated version Hajri Al-Shehri, Michelle C. Stanton, James E. LaCourse, Aaron Atuhaire, Moses Arinaitwe, Aida Wamboko, Moses Adriko, Narcis B. Kabatereine, J. Russell Stothard; An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda, Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 110, Issue 10, 1 October 2016, Pages 597–603, https://doi.org/10.1093/trstmh/trw072 is available online at: https://academic.oup.com/trstmh/article/110/10/597/2548938

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An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda

Research output: Contribution to journalJournal article

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An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda. / Al-Shehri, Hajri; Stanton, Michelle C; LaCourse, James E; Atuhaire, Aaron; Arinaitwe, Moses; Wamboko, Aida; Adriko, Moses; Kabatereine, Narcis B; Stothard, J Russell.

In: Transactions of The Royal Society of Tropical Medicine and Hygiene, Vol. 110, No. 10, 01.12.2016, p. 597-603.

Research output: Contribution to journalJournal article

Harvard

Al-Shehri, H, Stanton, MC, LaCourse, JE, Atuhaire, A, Arinaitwe, M, Wamboko, A, Adriko, M, Kabatereine, NB & Stothard, JR 2016, 'An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda', Transactions of The Royal Society of Tropical Medicine and Hygiene, vol. 110, no. 10, pp. 597-603. https://doi.org/10.1093/trstmh/trw072

APA

Al-Shehri, H., Stanton, M. C., LaCourse, J. E., Atuhaire, A., Arinaitwe, M., Wamboko, A., Adriko, M., Kabatereine, N. B., & Stothard, J. R. (2016). An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda. Transactions of The Royal Society of Tropical Medicine and Hygiene, 110(10), 597-603. https://doi.org/10.1093/trstmh/trw072

Vancouver

Al-Shehri H, Stanton MC, LaCourse JE, Atuhaire A, Arinaitwe M, Wamboko A et al. An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda. Transactions of The Royal Society of Tropical Medicine and Hygiene. 2016 Dec 1;110(10):597-603. https://doi.org/10.1093/trstmh/trw072

Author

Al-Shehri, Hajri ; Stanton, Michelle C ; LaCourse, James E ; Atuhaire, Aaron ; Arinaitwe, Moses ; Wamboko, Aida ; Adriko, Moses ; Kabatereine, Narcis B ; Stothard, J Russell. / An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda. In: Transactions of The Royal Society of Tropical Medicine and Hygiene. 2016 ; Vol. 110, No. 10. pp. 597-603.

Bibtex

@article{5362b792a8484fd1a7920cff19d39bf0,
title = "An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda",
abstract = "BACKGROUND: Water-borne parasitic diseases associated with poverty still blight the lives of African school children. In Uganda, intestinal schistosomiasis is still common along the shoreline of Lake Albert, despite ongoing control, and co-infection with giardiasis and malaria is poorly described. To shed light on putative interactions between diseases, a prospective cross-sectional parasitological survey was undertaken in five primary schools.METHODS: Stool samples from 254 school children, aged 5-10 years, were examined by microscopy and rapid diagnostic tests (RDTs), with additional real-time PCR assays for detection of Giardia DNA. A finger-prick blood sample was also taken from each child and tested for malaria, and haemoblobin levels measured. Assocations between diseases and anaemia were assessed.RESULTS: Intestinal schistosomiasis (46.5%), giardiasis (41.6%) and malaria (56.2%) were common, and a quarter of children were anaemic (<115 g/L). Up to 87.0% of children were excreting Giardia DNA and the prevalence of heavy infection by real-time PCR (Ct≤19) was 19.5%, being positively associated with light, moderate and heavy egg-patent schistosomiasis, as well as with anaemia.CONCLUSIONS: In this setting, an extensive burden of giardiasis was revealed with heavy intensity infections associated with egg-patent intestinal schistosomiasis and anaemia. To improve child health, greater attention on giardiasis is needed along with exploring joined-up actions across diseases that promote better water hygiene and sanitation measures.",
keywords = "Anemia, Animals, Child, Coinfection, Cross-Sectional Studies, Feces, Female, Giardiasis, Health Behavior, Humans, Lakes, Malaria, Male, Prevalence, Prospective Studies, Real-Time Polymerase Chain Reaction, Sanitation, Schistosomiasis mansoni, School Health Services, Schools, Uganda, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't",
author = "Hajri Al-Shehri and Stanton, {Michelle C} and LaCourse, {James E} and Aaron Atuhaire and Moses Arinaitwe and Aida Wamboko and Moses Adriko and Kabatereine, {Narcis B} and Stothard, {J Russell}",
note = "This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Transactions of the Royal Society of Tropical Medicine and Hygiene following peer review. The definitive publisher-authenticated version Hajri Al-Shehri, Michelle C. Stanton, James E. LaCourse, Aaron Atuhaire, Moses Arinaitwe, Aida Wamboko, Moses Adriko, Narcis B. Kabatereine, J. Russell Stothard; An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda, Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 110, Issue 10, 1 October 2016, Pages 597–603, https://doi.org/10.1093/trstmh/trw072 is available online at: https://academic.oup.com/trstmh/article/110/10/597/2548938",
year = "2016",
month = dec,
day = "1",
doi = "10.1093/trstmh/trw072",
language = "English",
volume = "110",
pages = "597--603",
journal = "Transactions of The Royal Society of Tropical Medicine and Hygiene",
issn = "0035-9203",
publisher = "Oxford University Press Inc",
number = "10",

}

RIS

TY - JOUR

T1 - An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda

AU - Al-Shehri, Hajri

AU - Stanton, Michelle C

AU - LaCourse, James E

AU - Atuhaire, Aaron

AU - Arinaitwe, Moses

AU - Wamboko, Aida

AU - Adriko, Moses

AU - Kabatereine, Narcis B

AU - Stothard, J Russell

N1 - This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Transactions of the Royal Society of Tropical Medicine and Hygiene following peer review. The definitive publisher-authenticated version Hajri Al-Shehri, Michelle C. Stanton, James E. LaCourse, Aaron Atuhaire, Moses Arinaitwe, Aida Wamboko, Moses Adriko, Narcis B. Kabatereine, J. Russell Stothard; An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda, Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 110, Issue 10, 1 October 2016, Pages 597–603, https://doi.org/10.1093/trstmh/trw072 is available online at: https://academic.oup.com/trstmh/article/110/10/597/2548938

PY - 2016/12/1

Y1 - 2016/12/1

N2 - BACKGROUND: Water-borne parasitic diseases associated with poverty still blight the lives of African school children. In Uganda, intestinal schistosomiasis is still common along the shoreline of Lake Albert, despite ongoing control, and co-infection with giardiasis and malaria is poorly described. To shed light on putative interactions between diseases, a prospective cross-sectional parasitological survey was undertaken in five primary schools.METHODS: Stool samples from 254 school children, aged 5-10 years, were examined by microscopy and rapid diagnostic tests (RDTs), with additional real-time PCR assays for detection of Giardia DNA. A finger-prick blood sample was also taken from each child and tested for malaria, and haemoblobin levels measured. Assocations between diseases and anaemia were assessed.RESULTS: Intestinal schistosomiasis (46.5%), giardiasis (41.6%) and malaria (56.2%) were common, and a quarter of children were anaemic (<115 g/L). Up to 87.0% of children were excreting Giardia DNA and the prevalence of heavy infection by real-time PCR (Ct≤19) was 19.5%, being positively associated with light, moderate and heavy egg-patent schistosomiasis, as well as with anaemia.CONCLUSIONS: In this setting, an extensive burden of giardiasis was revealed with heavy intensity infections associated with egg-patent intestinal schistosomiasis and anaemia. To improve child health, greater attention on giardiasis is needed along with exploring joined-up actions across diseases that promote better water hygiene and sanitation measures.

AB - BACKGROUND: Water-borne parasitic diseases associated with poverty still blight the lives of African school children. In Uganda, intestinal schistosomiasis is still common along the shoreline of Lake Albert, despite ongoing control, and co-infection with giardiasis and malaria is poorly described. To shed light on putative interactions between diseases, a prospective cross-sectional parasitological survey was undertaken in five primary schools.METHODS: Stool samples from 254 school children, aged 5-10 years, were examined by microscopy and rapid diagnostic tests (RDTs), with additional real-time PCR assays for detection of Giardia DNA. A finger-prick blood sample was also taken from each child and tested for malaria, and haemoblobin levels measured. Assocations between diseases and anaemia were assessed.RESULTS: Intestinal schistosomiasis (46.5%), giardiasis (41.6%) and malaria (56.2%) were common, and a quarter of children were anaemic (<115 g/L). Up to 87.0% of children were excreting Giardia DNA and the prevalence of heavy infection by real-time PCR (Ct≤19) was 19.5%, being positively associated with light, moderate and heavy egg-patent schistosomiasis, as well as with anaemia.CONCLUSIONS: In this setting, an extensive burden of giardiasis was revealed with heavy intensity infections associated with egg-patent intestinal schistosomiasis and anaemia. To improve child health, greater attention on giardiasis is needed along with exploring joined-up actions across diseases that promote better water hygiene and sanitation measures.

KW - Anemia

KW - Animals

KW - Child

KW - Coinfection

KW - Cross-Sectional Studies

KW - Feces

KW - Female

KW - Giardiasis

KW - Health Behavior

KW - Humans

KW - Lakes

KW - Malaria

KW - Male

KW - Prevalence

KW - Prospective Studies

KW - Real-Time Polymerase Chain Reaction

KW - Sanitation

KW - Schistosomiasis mansoni

KW - School Health Services

KW - Schools

KW - Uganda

KW - Journal Article

KW - Multicenter Study

KW - Research Support, Non-U.S. Gov't

U2 - 10.1093/trstmh/trw072

DO - 10.1093/trstmh/trw072

M3 - Journal article

C2 - 27864517

VL - 110

SP - 597

EP - 603

JO - Transactions of The Royal Society of Tropical Medicine and Hygiene

JF - Transactions of The Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 10

ER -