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An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys

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An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys. / Cano, Jorge; Moraga, Paula; Nikolay, Birgit et al.
In: Transactions of The Royal Society of Tropical Medicine and Hygiene, Vol. 109, No. 8, 08.2015, p. 529-531.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Cano, J, Moraga, P, Nikolay, B, Rebollo, MP, Okorie, PN, Davies, E, Njenga, SM, Bockarie, MJ & Brooker, SJ 2015, 'An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys', Transactions of The Royal Society of Tropical Medicine and Hygiene, vol. 109, no. 8, pp. 529-531. https://doi.org/10.1093/trstmh/trv048

APA

Cano, J., Moraga, P., Nikolay, B., Rebollo, M. P., Okorie, P. N., Davies, E., Njenga, S. M., Bockarie, M. J., & Brooker, S. J. (2015). An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys. Transactions of The Royal Society of Tropical Medicine and Hygiene, 109(8), 529-531. https://doi.org/10.1093/trstmh/trv048

Vancouver

Cano J, Moraga P, Nikolay B, Rebollo MP, Okorie PN, Davies E et al. An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys. Transactions of The Royal Society of Tropical Medicine and Hygiene. 2015 Aug;109(8):529-531. doi: 10.1093/trstmh/trv048

Author

Cano, Jorge ; Moraga, Paula ; Nikolay, Birgit et al. / An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys. In: Transactions of The Royal Society of Tropical Medicine and Hygiene. 2015 ; Vol. 109, No. 8. pp. 529-531.

Bibtex

@article{c277b44c12c24e7c9061a60a8a1848a9,
title = "An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys",
abstract = "BACKGROUND: The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known.METHODS: This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures.RESULTS AND CONCLUSIONS: In some settings there was a very large disparity, up to 40-70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed.",
keywords = "Animals, Antigens, Helminth, Carrier State, Elephantiasis, Filarial, Humans, Microfilariae, Surveys and Questionnaires, Wuchereria bancrofti, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Jorge Cano and Paula Moraga and Birgit Nikolay and Rebollo, {Maria P} and Okorie, {Patricia N} and Emmanuel Davies and Njenga, {Sammy M} and Bockarie, {Moses J} and Brooker, {Simon J}",
note = "{\textcopyright} The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2015",
month = aug,
doi = "10.1093/trstmh/trv048",
language = "English",
volume = "109",
pages = "529--531",
journal = "Transactions of The Royal Society of Tropical Medicine and Hygiene",
issn = "0035-9203",
publisher = "Oxford University Press Inc",
number = "8",

}

RIS

TY - JOUR

T1 - An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys

AU - Cano, Jorge

AU - Moraga, Paula

AU - Nikolay, Birgit

AU - Rebollo, Maria P

AU - Okorie, Patricia N

AU - Davies, Emmanuel

AU - Njenga, Sammy M

AU - Bockarie, Moses J

AU - Brooker, Simon J

N1 - © The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2015/8

Y1 - 2015/8

N2 - BACKGROUND: The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known.METHODS: This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures.RESULTS AND CONCLUSIONS: In some settings there was a very large disparity, up to 40-70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed.

AB - BACKGROUND: The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known.METHODS: This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures.RESULTS AND CONCLUSIONS: In some settings there was a very large disparity, up to 40-70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed.

KW - Animals

KW - Antigens, Helminth

KW - Carrier State

KW - Elephantiasis, Filarial

KW - Humans

KW - Microfilariae

KW - Surveys and Questionnaires

KW - Wuchereria bancrofti

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1093/trstmh/trv048

DO - 10.1093/trstmh/trv048

M3 - Journal article

C2 - 26101292

VL - 109

SP - 529

EP - 531

JO - Transactions of The Royal Society of Tropical Medicine and Hygiene

JF - Transactions of The Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 8

ER -