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Ancestral processes for non-neutral models of complex diseases.

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Ancestral processes for non-neutral models of complex diseases. / Fearnhead, Paul.
In: Theoretical Population Biology, Vol. 63, No. 2, 03.2003, p. 115-130.

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Fearnhead P. Ancestral processes for non-neutral models of complex diseases. Theoretical Population Biology. 2003 Mar;63(2):115-130. doi: 10.1016/S0040-5809(02)00049-7

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Fearnhead, Paul. / Ancestral processes for non-neutral models of complex diseases. In: Theoretical Population Biology. 2003 ; Vol. 63, No. 2. pp. 115-130.

Bibtex

@article{c218ae0c0d774811ba8d5d361d126cba,
title = "Ancestral processes for non-neutral models of complex diseases.",
abstract = "We consider non-neutral models for unlinked loci, where the fitness of a chromosome or individual is not multiplicative across loci. Such models are suitable for many complex diseases, where there are gene-interactions. We derive a genealogical process for such models, called the complex selection graph (CSG). This coalescent-type process is related to the ancestral selection graph, and is derived from the ancestral influence graph by considering the limit as the recombination rate between loci gets large. We analyse the CSG both theoretically and via simulation. The main results are that the gene-interactions do not produce linkage disequilibrium, but do produce dependencies in allele frequencies between loci. For small selection rates, the distributions of the genealogy and the allele frequencies at a single locus are well-approximated by their distributions under a single locus model, where the fitness of each allele is the average of the true fitnesses of that allele with respect to the distribution of alleles at other loci.",
keywords = "Ancestral influence graph, Ancestral selection graph, Complex diseases, Gene-interaction, Genic selection, Linkage disequilibrium",
author = "Paul Fearnhead",
year = "2003",
month = mar,
doi = "10.1016/S0040-5809(02)00049-7",
language = "English",
volume = "63",
pages = "115--130",
journal = "Theoretical Population Biology",
issn = "1096-0325",
publisher = "Academic Press Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Ancestral processes for non-neutral models of complex diseases.

AU - Fearnhead, Paul

PY - 2003/3

Y1 - 2003/3

N2 - We consider non-neutral models for unlinked loci, where the fitness of a chromosome or individual is not multiplicative across loci. Such models are suitable for many complex diseases, where there are gene-interactions. We derive a genealogical process for such models, called the complex selection graph (CSG). This coalescent-type process is related to the ancestral selection graph, and is derived from the ancestral influence graph by considering the limit as the recombination rate between loci gets large. We analyse the CSG both theoretically and via simulation. The main results are that the gene-interactions do not produce linkage disequilibrium, but do produce dependencies in allele frequencies between loci. For small selection rates, the distributions of the genealogy and the allele frequencies at a single locus are well-approximated by their distributions under a single locus model, where the fitness of each allele is the average of the true fitnesses of that allele with respect to the distribution of alleles at other loci.

AB - We consider non-neutral models for unlinked loci, where the fitness of a chromosome or individual is not multiplicative across loci. Such models are suitable for many complex diseases, where there are gene-interactions. We derive a genealogical process for such models, called the complex selection graph (CSG). This coalescent-type process is related to the ancestral selection graph, and is derived from the ancestral influence graph by considering the limit as the recombination rate between loci gets large. We analyse the CSG both theoretically and via simulation. The main results are that the gene-interactions do not produce linkage disequilibrium, but do produce dependencies in allele frequencies between loci. For small selection rates, the distributions of the genealogy and the allele frequencies at a single locus are well-approximated by their distributions under a single locus model, where the fitness of each allele is the average of the true fitnesses of that allele with respect to the distribution of alleles at other loci.

KW - Ancestral influence graph

KW - Ancestral selection graph

KW - Complex diseases

KW - Gene-interaction

KW - Genic selection

KW - Linkage disequilibrium

U2 - 10.1016/S0040-5809(02)00049-7

DO - 10.1016/S0040-5809(02)00049-7

M3 - Journal article

VL - 63

SP - 115

EP - 130

JO - Theoretical Population Biology

JF - Theoretical Population Biology

SN - 1096-0325

IS - 2

ER -