Home > Research > Publications & Outputs > Antigenic cross-reactivity between Necator amer...
View graph of relations

Antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides in a community in Papua New Guinea infected predominantly with hookworm.

Research output: Contribution to journalJournal article

Published
  • D. I. Pritchard
  • R. J. Quinnell
  • Paul G. McKean
  • L. Walsh
  • K. V. Leggett
  • A. F. Slater
  • A. Raiko
  • D. D. Dale
  • A. E. Keymer
Close
<mark>Journal publication date</mark>07/1991
<mark>Journal</mark>Transactions of The Royal Society of Tropical Medicine and Hygiene
Issue number4
Volume85
Number of pages4
Pages (from-to)511-514
Publication statusPublished
Original languageEnglish

Abstract

Sero-epidemiological data are presented in which antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides has been investigated in a community in Papua New Guinea infected predominantly with N. americanus. It is our contention that the antigenic cross-reactivity which undoubtedly exists between these species accounted for (i) a peak in antibody levels against N. americanus in 10-13 years old children (driven by infection with A. lumbricoides), and (ii) the maintenance of apparent antibody levels against A. lumbricoides in older age groups (driven by infection with N. americanus in the absence of overt infection with A. lumbricoides). Cross-reactivity was analysed further, and apparently N. americanus-specific epitopes identified, by immunoblotting. These observations could have considerable bearing on the interpretation of data from sero-epidemiological studies which failed to take account of concurrent infection with these parasites.