Home > Research > Publications & Outputs > APOE-ɛ4, white matter hyperintensities, and cog...

Research

Electronic data

Links

Text available via DOI:

View graph of relations

APOE-ɛ4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

APOE-ɛ4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia. / Saeed Mirza, Saira; Saeed, Usman; Knight, Jo et al.
In: Neurology, Vol. 93, No. 19, 05.11.2019, p. e1807-e1819.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Saeed Mirza, S, Saeed, U, Knight, J, Ramirez, J, Stuss, D, Keith, J, Nestor, SM, Yu, D, Swardfager, W, Rogaeva, E, George-Hyslop, PS, Black, SE & Masellis, M 2019, 'APOE-ɛ4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia', Neurology, vol. 93, no. 19, pp. e1807-e1819. https://doi.org/10.1212/WNL.0000000000008377

APA

Saeed Mirza, S., Saeed, U., Knight, J., Ramirez, J., Stuss, D., Keith, J., Nestor, S. M., Yu, D., Swardfager, W., Rogaeva, E., George-Hyslop, P. S., Black, S. E., & Masellis, M. (2019). APOE-ɛ4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia. Neurology, 93(19), e1807-e1819. https://doi.org/10.1212/WNL.0000000000008377

Vancouver

Saeed Mirza S, Saeed U, Knight J, Ramirez J, Stuss D, Keith J et al. APOE-ɛ4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia. Neurology. 2019 Nov 5;93(19):e1807-e1819. Epub 2019 Oct 1. doi: 10.1212/WNL.0000000000008377

Author

Saeed Mirza, Saira ; Saeed, Usman ; Knight, Jo et al. / APOE-ɛ4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia. In: Neurology. 2019 ; Vol. 93, No. 19. pp. e1807-e1819.

Bibtex

@article{7e959ea7ccb14548b73c3bc1aefcaa1c,
title = "APOE-ɛ4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia",
abstract = "Objective To determine if APOE ε4 influences the association between white matter hyperintensities (WMH) and cognitive impairment in Alzheimer disease (AD) and dementia with Lewy bodies (DLB).Methods A total of 289 patients (AD = 239; DLB = 50) underwent volumetric MRI, neuropsychological testing, and APOE ε4 genotyping. Total WMH volumes were quantified. Neuropsychological test scores were included in a confirmatory factor analysis to identify cognitive domains encompassing attention/executive functions, learning/memory, and language, and factor scores for each domain were calculated per participant. After testing interactions between WMH and APOE ε4 in the full sample, we tested associations of WMH with factor scores using linear regression models in APOE ε4 carriers (n = 167) and noncarriers (n = 122). We hypothesized that greater WMH volume would relate to worse cognition more strongly in APOE ε4 carriers. Findings were replicated in 198 patients with AD from the Alzheimer's Disease Neuroimaging Initiative (ADNI-I), and estimates from both samples were meta-analyzed.Results A significant interaction was observed between WMH and APOE ε4 for language, but not for memory or executive functions. Separate analyses in APOE ε4 carriers and noncarriers showed that greater WMH volume was associated with worse attention/executive functions, learning/memory, and language in APOE ε4 carriers only. In ADNI-I, greater WMH burden was associated with worse attention/executive functions and language in APOE ε4 carriers only. No significant associations were observed in noncarriers. Meta-analyses showed that greater WMH volume was associated with worse performance on all cognitive domains in APOE ε4 carriers only.Conclusion APOE ε4 may influence the association between WMH and cognitive performance in AD and DLB.",
author = "{Saeed Mirza}, Saira and Usman Saeed and Jo Knight and Joel Ramirez and Donald Stuss and Julia Keith and Nestor, {Sean M.} and Di Yu and Walter Swardfager and Ekaterina Rogaeva and George-Hyslop, {Peter St.} and Black, {Sandra E.} and Mario Masellis",
year = "2019",
month = nov,
day = "5",
doi = "10.1212/WNL.0000000000008377",
language = "English",
volume = "93",
pages = "e1807--e1819",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "19",

}

RIS

TY - JOUR

T1 - APOE-ɛ4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia

AU - Saeed Mirza, Saira

AU - Saeed, Usman

AU - Knight, Jo

AU - Ramirez, Joel

AU - Stuss, Donald

AU - Keith, Julia

AU - Nestor, Sean M.

AU - Yu, Di

AU - Swardfager, Walter

AU - Rogaeva, Ekaterina

AU - George-Hyslop, Peter St.

AU - Black, Sandra E.

AU - Masellis, Mario

PY - 2019/11/5

Y1 - 2019/11/5

N2 - Objective To determine if APOE ε4 influences the association between white matter hyperintensities (WMH) and cognitive impairment in Alzheimer disease (AD) and dementia with Lewy bodies (DLB).Methods A total of 289 patients (AD = 239; DLB = 50) underwent volumetric MRI, neuropsychological testing, and APOE ε4 genotyping. Total WMH volumes were quantified. Neuropsychological test scores were included in a confirmatory factor analysis to identify cognitive domains encompassing attention/executive functions, learning/memory, and language, and factor scores for each domain were calculated per participant. After testing interactions between WMH and APOE ε4 in the full sample, we tested associations of WMH with factor scores using linear regression models in APOE ε4 carriers (n = 167) and noncarriers (n = 122). We hypothesized that greater WMH volume would relate to worse cognition more strongly in APOE ε4 carriers. Findings were replicated in 198 patients with AD from the Alzheimer's Disease Neuroimaging Initiative (ADNI-I), and estimates from both samples were meta-analyzed.Results A significant interaction was observed between WMH and APOE ε4 for language, but not for memory or executive functions. Separate analyses in APOE ε4 carriers and noncarriers showed that greater WMH volume was associated with worse attention/executive functions, learning/memory, and language in APOE ε4 carriers only. In ADNI-I, greater WMH burden was associated with worse attention/executive functions and language in APOE ε4 carriers only. No significant associations were observed in noncarriers. Meta-analyses showed that greater WMH volume was associated with worse performance on all cognitive domains in APOE ε4 carriers only.Conclusion APOE ε4 may influence the association between WMH and cognitive performance in AD and DLB.

AB - Objective To determine if APOE ε4 influences the association between white matter hyperintensities (WMH) and cognitive impairment in Alzheimer disease (AD) and dementia with Lewy bodies (DLB).Methods A total of 289 patients (AD = 239; DLB = 50) underwent volumetric MRI, neuropsychological testing, and APOE ε4 genotyping. Total WMH volumes were quantified. Neuropsychological test scores were included in a confirmatory factor analysis to identify cognitive domains encompassing attention/executive functions, learning/memory, and language, and factor scores for each domain were calculated per participant. After testing interactions between WMH and APOE ε4 in the full sample, we tested associations of WMH with factor scores using linear regression models in APOE ε4 carriers (n = 167) and noncarriers (n = 122). We hypothesized that greater WMH volume would relate to worse cognition more strongly in APOE ε4 carriers. Findings were replicated in 198 patients with AD from the Alzheimer's Disease Neuroimaging Initiative (ADNI-I), and estimates from both samples were meta-analyzed.Results A significant interaction was observed between WMH and APOE ε4 for language, but not for memory or executive functions. Separate analyses in APOE ε4 carriers and noncarriers showed that greater WMH volume was associated with worse attention/executive functions, learning/memory, and language in APOE ε4 carriers only. In ADNI-I, greater WMH burden was associated with worse attention/executive functions and language in APOE ε4 carriers only. No significant associations were observed in noncarriers. Meta-analyses showed that greater WMH volume was associated with worse performance on all cognitive domains in APOE ε4 carriers only.Conclusion APOE ε4 may influence the association between WMH and cognitive performance in AD and DLB.

U2 - 10.1212/WNL.0000000000008377

DO - 10.1212/WNL.0000000000008377

M3 - Journal article

VL - 93

SP - e1807-e1819

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 19

ER -