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Assessment of photon migration for subsurface probing in selected types of bone using spatially offset Raman spectroscopy

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Assessment of photon migration for subsurface probing in selected types of bone using spatially offset Raman spectroscopy. / Sowoidnich, Kay ; Churchwell, John; Buckley, Kevin; Kerns, Jemma Gillian; Goodship, Allen; Parker, Anthony; Matousek, Pavel.

In: Proceedings of SPIE, Vol. 9887, 988719, 27.04.2016.

Research output: Contribution to journalJournal article

Harvard

Sowoidnich, K, Churchwell, J, Buckley, K, Kerns, JG, Goodship, A, Parker, A & Matousek, P 2016, 'Assessment of photon migration for subsurface probing in selected types of bone using spatially offset Raman spectroscopy', Proceedings of SPIE, vol. 9887, 988719. https://doi.org/10.1117/12.2227384

APA

Sowoidnich, K., Churchwell, J., Buckley, K., Kerns, J. G., Goodship, A., Parker, A., & Matousek, P. (2016). Assessment of photon migration for subsurface probing in selected types of bone using spatially offset Raman spectroscopy. Proceedings of SPIE, 9887, [988719]. https://doi.org/10.1117/12.2227384

Vancouver

Sowoidnich K, Churchwell J, Buckley K, Kerns JG, Goodship A, Parker A et al. Assessment of photon migration for subsurface probing in selected types of bone using spatially offset Raman spectroscopy. Proceedings of SPIE. 2016 Apr 27;9887. 988719. https://doi.org/10.1117/12.2227384

Author

Sowoidnich, Kay ; Churchwell, John ; Buckley, Kevin ; Kerns, Jemma Gillian ; Goodship, Allen ; Parker, Anthony ; Matousek, Pavel. / Assessment of photon migration for subsurface probing in selected types of bone using spatially offset Raman spectroscopy. In: Proceedings of SPIE. 2016 ; Vol. 9887.

Bibtex

@article{5784db10a84b4f9690d24e2e0a73175d,
title = "Assessment of photon migration for subsurface probing in selected types of bone using spatially offset Raman spectroscopy",
abstract = "Bone diseases and disorders are a growing challenge in aging populations; so effective diagnostic and therapeutic solutions are now essential to manage the demands of healthcare sectors effectively. Spatially offset Raman spectroscopy (SORS) allows for chemically specific sub-surface probing and has a great potential to become an in vivo tool for early non-invasive detection of bone conditions. Bone is a complex hierarchical material and the volume probed by SORS is dependent on its optical properties. Understanding and taking into account the variations in diffuse scattering properties of light in various bone types is essential for the effective development and optimization of SORS as a diagnostic in vivo tool for characterizing bone disease. This study presents SORS investigations at 830 nm excitation on two specific types of bone with differing mineralization levels. Thin slices of bone from horse metacarpal cortex (0.6 mm thick) and whale bulla (1.0 mm thick) were cut and stacked on top of each other (4-7 layers with a total thickness of 4.1 mm). To investigate the depth origin of the detected Raman signal inside the bone a 0.38 mm thin Teflon slice was used as test sample and inserted in between the layers of stacked bone slices. For both types of bone it could be demonstrated that chemically specific Raman signatures different from those of normal bone can be retrieved through 3.8-4.0 mm of overlying bone material with a spatial offset of 7-8 mm. The determined penetration depths can be correlated with the mechanical and optical properties of the specimens. The findings of this study increase our understanding of SORS analysis of bone and thus have impact for medical diagnostic applications e.g. enabling the non-invasive detection of spectral changes caused by degeneration, infection or cancer deep inside the bone matrix.",
author = "Kay Sowoidnich and John Churchwell and Kevin Buckley and Kerns, {Jemma Gillian} and Allen Goodship and Anthony Parker and Pavel Matousek",
year = "2016",
month = apr
day = "27",
doi = "10.1117/12.2227384",
language = "English",
volume = "9887",
journal = "Proceedings of SPIE",
issn = "0277-786X",
publisher = "SPIE",

}

RIS

TY - JOUR

T1 - Assessment of photon migration for subsurface probing in selected types of bone using spatially offset Raman spectroscopy

AU - Sowoidnich, Kay

AU - Churchwell, John

AU - Buckley, Kevin

AU - Kerns, Jemma Gillian

AU - Goodship, Allen

AU - Parker, Anthony

AU - Matousek, Pavel

PY - 2016/4/27

Y1 - 2016/4/27

N2 - Bone diseases and disorders are a growing challenge in aging populations; so effective diagnostic and therapeutic solutions are now essential to manage the demands of healthcare sectors effectively. Spatially offset Raman spectroscopy (SORS) allows for chemically specific sub-surface probing and has a great potential to become an in vivo tool for early non-invasive detection of bone conditions. Bone is a complex hierarchical material and the volume probed by SORS is dependent on its optical properties. Understanding and taking into account the variations in diffuse scattering properties of light in various bone types is essential for the effective development and optimization of SORS as a diagnostic in vivo tool for characterizing bone disease. This study presents SORS investigations at 830 nm excitation on two specific types of bone with differing mineralization levels. Thin slices of bone from horse metacarpal cortex (0.6 mm thick) and whale bulla (1.0 mm thick) were cut and stacked on top of each other (4-7 layers with a total thickness of 4.1 mm). To investigate the depth origin of the detected Raman signal inside the bone a 0.38 mm thin Teflon slice was used as test sample and inserted in between the layers of stacked bone slices. For both types of bone it could be demonstrated that chemically specific Raman signatures different from those of normal bone can be retrieved through 3.8-4.0 mm of overlying bone material with a spatial offset of 7-8 mm. The determined penetration depths can be correlated with the mechanical and optical properties of the specimens. The findings of this study increase our understanding of SORS analysis of bone and thus have impact for medical diagnostic applications e.g. enabling the non-invasive detection of spectral changes caused by degeneration, infection or cancer deep inside the bone matrix.

AB - Bone diseases and disorders are a growing challenge in aging populations; so effective diagnostic and therapeutic solutions are now essential to manage the demands of healthcare sectors effectively. Spatially offset Raman spectroscopy (SORS) allows for chemically specific sub-surface probing and has a great potential to become an in vivo tool for early non-invasive detection of bone conditions. Bone is a complex hierarchical material and the volume probed by SORS is dependent on its optical properties. Understanding and taking into account the variations in diffuse scattering properties of light in various bone types is essential for the effective development and optimization of SORS as a diagnostic in vivo tool for characterizing bone disease. This study presents SORS investigations at 830 nm excitation on two specific types of bone with differing mineralization levels. Thin slices of bone from horse metacarpal cortex (0.6 mm thick) and whale bulla (1.0 mm thick) were cut and stacked on top of each other (4-7 layers with a total thickness of 4.1 mm). To investigate the depth origin of the detected Raman signal inside the bone a 0.38 mm thin Teflon slice was used as test sample and inserted in between the layers of stacked bone slices. For both types of bone it could be demonstrated that chemically specific Raman signatures different from those of normal bone can be retrieved through 3.8-4.0 mm of overlying bone material with a spatial offset of 7-8 mm. The determined penetration depths can be correlated with the mechanical and optical properties of the specimens. The findings of this study increase our understanding of SORS analysis of bone and thus have impact for medical diagnostic applications e.g. enabling the non-invasive detection of spectral changes caused by degeneration, infection or cancer deep inside the bone matrix.

U2 - 10.1117/12.2227384

DO - 10.1117/12.2227384

M3 - Journal article

VL - 9887

JO - Proceedings of SPIE

JF - Proceedings of SPIE

SN - 0277-786X

M1 - 988719

ER -