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Asymmetric Decarboxylative Allylation of Oxindoles

Research output: Contribution to journalJournal article

<mark>Journal publication date</mark>19/08/2011
<mark>Journal</mark>Organic Letters
Issue number16
Number of pages4
Pages (from-to)4264-4267
<mark>Original language</mark>English


An asymmetric decarboxylative palladium-catalyzed allylation of alkyl- and aryl-substituted oxindoles has been developed, enabling the installation of an all-carbon quaternary chiral center at the oxindole 3-position in excellent yields and good to excellent enantioselectivity. An intriguing substrate-dependent reversal in stereoselectivity has been observed, whereby the size of the substituent determines the facial selectivity in the allylation step.