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Home > Research > Publications & Outputs > Asymmetric Decarboxylative Allylation of Oxindoles
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Asymmetric Decarboxylative Allylation of Oxindoles

Research output: Contribution to journalJournal article

Published

Journal publication date19/08/2011
JournalOrganic letters
Journal number16
Volume13
Number of pages4
Pages4264-4267
Original languageEnglish

Abstract

An asymmetric decarboxylative palladium-catalyzed allylation of alkyl- and aryl-substituted oxindoles has been developed, enabling the installation of an all-carbon quaternary chiral center at the oxindole 3-position in excellent yields and good to excellent enantioselectivity. An intriguing substrate-dependent reversal in stereoselectivity has been observed, whereby the size of the substituent determines the facial selectivity in the allylation step.