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Biocompatible choline based ionic salts: solubility in short-chain alcohols

Research output: Contribution to journalJournal article


  • Joana M. Lopes
  • Ana B. Paninho
  • Marta F. Môlho
  • Ana V. M. Nunes
  • Angelo Rocha
  • Nuno M. T. Lourenço
  • Vesna Najdanovic-Visak
Journal publication date12/2013
JournalJournal of Chemical Thermodynamics
Original languageEnglish


In this work we report data on solubility of choline chloride and choline acetate in shortchain linear alcohols (ethanol, 1-propanol and 1-butanol) at various temperatures. Furthermore, we synthetized two choline derivatives: hydrogen
choline chloride glutarate ([CholGlut][Cl]) and hydrogen choline chloride succinate
([CholSucc][Cl]). Their characterization and solubility in short-chain alcohols as
a function of temperature are also included. Activity coefficients were calculated
and their comparisons with ideal solutions were discussed. The experimental data were correlated successfully by means of the semi-empirical Grant equation.