TY - JOUR

T1 - Biodegradable polyurethanes

T2 - biodegradable low adherence films for the prevention of adhesions after surgery

AU - Rehman, I.U.

PY - 1996

Y1 - 1996

N2 - Adhesions commonly occur after internal disease or surgery. The natural healing response leads to the formation of vascular and avascular adhesions after inflammatory diseases and surgical interventions. A barrier film could be incorporated during surgery between layers of tissues that must not adhere to one another. The film would be biodegradable so that it disappears over a period of time, and would ideally be two sided, allowing relative movement at that interface, while being firmly anchored on the opposite side to prevent displacement. Polyesterurethane-polydimethylsiloxane graft polymers are synthesised. Chemical characterisation of the polymer is performed by using Fourier Transform Infrared Spectroscopy and Gel Permeation Chromatography. In vitro hydrolytic degradation is carried out in which films are immersed at 37°C in alkaline solution. Degradation is assessed by tensile testing as a function of time to determine the degradation of mechanical strength, infrared spectroscopy, and mass loss. A titration method is also used to determine quantitatively the hydrolytic degradation. In order to study the adhesions of films, an in-vitro model based on a gelatine test, which is simple and rapid, is described. Suitable candidate films investigated from the in-vitro work are subjected to in vivo tests for both biodegradation and their ability to prevent adhesion.

AB - Adhesions commonly occur after internal disease or surgery. The natural healing response leads to the formation of vascular and avascular adhesions after inflammatory diseases and surgical interventions. A barrier film could be incorporated during surgery between layers of tissues that must not adhere to one another. The film would be biodegradable so that it disappears over a period of time, and would ideally be two sided, allowing relative movement at that interface, while being firmly anchored on the opposite side to prevent displacement. Polyesterurethane-polydimethylsiloxane graft polymers are synthesised. Chemical characterisation of the polymer is performed by using Fourier Transform Infrared Spectroscopy and Gel Permeation Chromatography. In vitro hydrolytic degradation is carried out in which films are immersed at 37°C in alkaline solution. Degradation is assessed by tensile testing as a function of time to determine the degradation of mechanical strength, infrared spectroscopy, and mass loss. A titration method is also used to determine quantitatively the hydrolytic degradation. In order to study the adhesions of films, an in-vitro model based on a gelatine test, which is simple and rapid, is described. Suitable candidate films investigated from the in-vitro work are subjected to in vivo tests for both biodegradation and their ability to prevent adhesion.

KW - Adhesions

KW - Characterisation co-polymers hydrolytic degradation

KW - In-vitro

KW - In-vivo

KW - Polyesters

KW - Polyurethanes

KW - Synthesis

KW - Adhesion

KW - Biofilms

KW - Degradation

KW - Fourier transform infrared spectroscopy

KW - Gel permeation chromatography

KW - Graft copolymers

KW - Strength of materials

KW - Surgery

KW - Titration

KW - Avascular adhesion

KW - Biodegradable low adherence films

KW - Biodegradable polyurethanes

KW - Hydrolytic degradation

KW - Vascular adhesion

KW - biomaterial

KW - polymer

KW - polyurethan

KW - adhesion

KW - animal

KW - article

KW - bioremediation

KW - chemistry

KW - comparative study

KW - materials testing

KW - methodology

KW - postoperative complication

KW - rat

KW - structure activity relation

KW - synthesis

KW - Adhesiveness

KW - Animals

KW - Biocompatible Materials

KW - Biodegradation, Environmental

KW - Materials Testing

KW - Polymers

KW - Postoperative Complications

KW - Rats

KW - Structure-Activity Relationship

U2 - 10.1177/088532829601100203

DO - 10.1177/088532829601100203

M3 - Journal article

VL - 11

SP - 182

EP - 257

JO - JOURNAL OF BIOMATERIALS APPLICATIONS

JF - JOURNAL OF BIOMATERIALS APPLICATIONS

SN - 0885-3282

IS - 2

ER -