Accepted author manuscript, 2.04 MB, Word document
Available under license: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Biomarkers for knee osteoarthritis
T2 - new technologies, new paradigms
AU - Spain, Lucy
AU - Rajoub, Bashar
AU - Schlueter, Daniela K.
AU - Waterton, John
AU - Bowes, Mike
AU - Shark, Lik-Kwan
AU - Diggle, Peter
AU - Goodacre, John
N1 - Date of Acceptance unknown. Corresponding author does not have the information.
PY - 2015/10
Y1 - 2015/10
N2 - There is a paucity of biomarkers in knee osteoarthritis (OA) to inform clinical decision making, evaluate treatments, enable early detection and identify people who are most likely to progress to severe OA. The absence of biomarkers places considerable limitations on the design of research studies, and is a barrier toward applying the principles of stratified medicine to knee OA. Here we describe key principles and processes of biomarker development and focus on two promising areas that draw upon technologies that have only relatively recently been developed for quantitative applications in clinical research, namely 3D MRI and acoustic emission. While still at an early stage, results to date show promising potential to open up interesting new paradigms in this field.
AB - There is a paucity of biomarkers in knee osteoarthritis (OA) to inform clinical decision making, evaluate treatments, enable early detection and identify people who are most likely to progress to severe OA. The absence of biomarkers places considerable limitations on the design of research studies, and is a barrier toward applying the principles of stratified medicine to knee OA. Here we describe key principles and processes of biomarker development and focus on two promising areas that draw upon technologies that have only relatively recently been developed for quantitative applications in clinical research, namely 3D MRI and acoustic emission. While still at an early stage, results to date show promising potential to open up interesting new paradigms in this field.
KW - 3D MRI
KW - acoustic emission
KW - biomarker
KW - knee osteoarthritis
U2 - 10.2217/ijr.15.32
DO - 10.2217/ijr.15.32
M3 - Journal article
VL - 10
SP - 287
EP - 297
JO - International Journal of Clinical Rheumatology
JF - International Journal of Clinical Rheumatology
SN - 1758-4280
IS - 4
ER -